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D R Gouldesbrough

Publications and source records attributed to D R Gouldesbrough.

24 records · Page 2Linked to original sources
PubMed1988

Use of immunohistochemical methods in the differential diagnosis between primary cerebellar haemangioblastoma and metastatic renal carcinoma.

The potential role of immunohistochemistry in making the distinction between primary cerebellar haemangioblastoma and metastatic renal carcinoma was investigated by examining the reaction pattern of 10 cerebellar haemangioblastomas (seven women, three men, aged 20-40 years) and 10 primary renal carcinomas (six men, four women, aged 49-82 years) to a panel of epithelial, glial, and neural/neuroendocrine antisera. The tumour cell membranes of the renal carcinomas stained strongly with epithelial membrane antigen (EMA); membrane staining was totally absent in the haemangioblastomas. Strong neurone specific enolase (NSE) and S100 staining were also seen in haemangioblastomas but were more variable than EMA staining in renal carcinomas. It is concluded that a panel of antisera is required to distinguish between histologically similar areas in primary haemangioblastomas and metastatic renal carcinomas, and that while complementing conventional histological techniques, new problems of interpretation result which must be taken into account.

Adult↗
PubMedDate not supplied

Elastofibroma of the forefoot.

Elastofibroma is an uncommon soft tissue lesion that most often presents as a mass in the lower scapular region of elderly female subjects. The authors report an elastofibroma arising in the right forefoot of a 63-year-old woman. Pain over the plantar aspect of the head of the third metatarsal preceded the formation of a tender mass. Although rare, elastofibroma should be considered in the differential diagnosis of painful conditions and tumors of the forefoot.

Collagen↗