PubMed Health⌕ Search

Biomedical subjects

D R Karnad

Publications and source records attributed to D R Karnad.

At least 19 recordsLinked to original sources
PubMed1992

Clinical and bacteriological profile of the ear in otogenic tetanus: a case control study.

Twenty two patients presented with otogenic tetanus. Seventeen patients had acute histories with only a single episode of otitis media with otorrhoea. Fifteen patients had unilateral central perforations, five had bilateral central perforations and two had no perforations but had acutely congested tympanic membranes which were bulging suggesting the presence of purulent fluid behind them. All patients with perforations had a purulent pulsatile discharge. A coexisting aerobic infection was seen in 85 per cent of the cultures and 59 per cent of these were due to staphylococcus aureus (versus 25 per cent in the controls). Only one patient had received partial immunization. Tetanus resulting from otitis media is not an indication for surgery.

Acute Disease↗
PubMed1992

Gastric colonization and pneumonia in intubated critically ill patients receiving stress ulcer prophylaxis: a randomized, controlled trial.

OBJECTIVE: To study the effects of pharmacologically increasing gastric pH on gastric colonization and the development of pneumonia in intubated critically ill patients. DESIGN: Randomized, controlled trial. SETTING: Medical ICU in a university hospital. PATIENTS: Thirty-four tracheotomized patients with tetanus. INTERVENTIONS: Sixteen patients received iv ranitidine to increase gastric pH greater than 4 (ranitidine group), while 18 patients received no prophylaxis for upper gastrointestinal bleeding (control group). MEASUREMENTS AND MAIN RESULTS: Mean gastric pH was higher in the ranitidine group (median 4.7, range 3.6 to 6.1) than in the control group (median 2.1, range 1.2 to 4.9; p less than .05). Gastric colonization occurred in 15 (94%) of 16 patients who received ranitidine, 2 days (median; range 1 to 5) after intubation; gastric colonization also occurred in all control patients (median 4 days, range 1 to 9; p less than .05). Pneumonia occurred in 13 (81%) of 16 patients who received ranitidine, 3 days (median, range 1 to 5) after intubation and in nine (50%) of 18 control patients (p less than .01) 5 days after tracheal intubation (median, range 3 to 14; p less than .01). Prior gastric colonization by the pathogen that caused pneumonia was demonstrable in nine (56%) of 16 patients who received ranitidine vs. eight (44%) of 18 control patients (p greater than .05). The risk for developing pneumonia in the ranitidine-treated group was highest in the first 4 days after tracheal intubation. There was no difference in the frequency of upper gastrointestinal hemorrhage in the two groups. CONCLUSIONS: Pharmacologically increasing gastric pH increases the risk for developing pneumonia in intubated critically ill patients. The pneumonia occurs earlier than in untreated control patients.

Adolescent↗
PubMed1992

Hypothermia due to transient hypothalamic dysfunction in tuberculous meningitis with hydrocephalus.

We report two patients with tuberculous meningitis and hydrocephalus who developed hypothermia that reversed after inserting a ventricular shunt for the hydrocephalus. Pressure on the thermoregulatory centre in the posterior hypothalamus near the dilated third ventricle might have been responsible. One patient developed hypotension during the transient hypothermia, which persisted and proved fatal.

Adult↗
PubMed1992

Tense ascites redefined: renal consequences of tense ascites in decompensated cirrhotics.

Cirrhotics with tense ascites fail to achieve increased diuresis in the supine position. To assess the role of inferior vena cava compression in this phenomenon, we studied cirrhotics with mild to moderate (n = 11) and tense (n = 2) ascites, and patients with membranous inferior vena cava obstruction (n = 2) before and after balloon dilatation, in the sitting, supine and 10 degrees head down tilted positions for 2 hours each. Urinary output (p < 0.005), creatinine clearance (p < 0.025) and sodium excretion (p < 0.025) increased in cirrhotics with mild to moderate ascites in the supine position, and further in the head down position. Similar changes occurred in patients with inferior vena cava membrane. In cirrhotics with tense ascites, these parameters did not change significantly in the supine position, but increased in the head down position. We conclude that failure to augment diuresis in the supine position in cirrhotics with tense ascites is not due to inferior vena cava obstruction alone but is probably also due to compression of the collateral vessels. This clinical observation may serve as a criterion for diagnosing tense ascites.

Ascites↗
PubMed1991

A scoring system to differentiate cirrhotic from non-cirrhotic portal hypertension.

When it is not possible to perform a liver biopsy in cirrhosis, one has to rely on suggestive clinical and biochemical parameters and imaging procedures to arrive at a presumptive diagnosis. Based on the statistical method described by Spiegelhalter and Knill-Jones, we have devised a scoring system to reliably differentiate cirrhotic from non-cirrhotic portal hypertension without a liver biopsy. Age, presence of ascites, liver scan result and serum albumin, taken together, could confirm or rule out the diagnosis of cirrhosis in two-thirds of patients with portal hypertension. A score of 5 or more suggested cirrhosis (sensitivity 78%), and of 5 or more suggested cirrhosis (sensitivity 78%), and a score of -6 or less suggested a non-cirrhotic cause (sensitivity 64%) for portal hypertension, both with 100% specificity. Eliminating liver scan result reduced both sensitivity and specificity, suggesting that liver scan is an important component of the score. This score may be useful not only in the management of individual patients but also to classify them in clinical trials.

Adult↗
PubMed1990

Respiratory mucus pH in tracheostomized intensive care unit patients: Effects of colonization and pneumonia.

Daily, we studied the effects of colonization and pneumonia on the pH of respiratory mucus in 23 critically ill patients. Sixteen patients had tracheobronchial colonization, and 11 of these subsequently developed pneumonia. Two other patients developed pneumonia without prior colonization. For the 13 patients with pneumonia, there was a significantly greater decrease in pH below the value recorded on the day of intubation vs. that for the ten patients who did not have pneumonia. In the 11 patients who developed initial colonization and then pneumonia, the pH did not change after colonization, but became acidic with the development of pneumonia. The pH returned to basal levels after recovery from pneumonia. We tested the pH value to differentiate between colonization and infection in these intubated critically ill patients. A decrease in pH greater than or equal to 0.2 below the pH value on the day of intubation could predict the presence of pneumonia with a positive predictive value of 90%. This decrease in pH occurred before or on the same day as the development of radiologically detectable pneumonia in most cases. Daily monitoring of the pH of tracheal mucus may be of value in critically ill intubated patients.

Colony Count, Microbial↗
PubMed1987

Head-down tilt as a physiological diuretic in normal controls and in patients with fluid-retaining states.

The effect of the sitting, supine, supine with legs elevated 10 degrees, and 10 degrees head-down tilt postures on renal fluid and electrolyte handling was investigated in 14 patients with hypoalbuminaemic fluid-retaining states and in 14 normal individuals. Basal (sitting) urine volume, creatinine clearance, and urinary electrolyte levels were significantly lower in patients than in controls. In patients the values of these variables increased progressively from the sitting to the supine to the legs elevated to the head-down postures. The percentage rise was higher in patients than in controls, to the extent that, in the head-low position, only creatinine clearance values remained lower in patients than in controls. The head-down posture acts as a physiological diuretic, enhancing diuresis by improving renal function in normal individuals and in patients with ascites and oedema due to hypoalbuminaemia; it also corrects the abnormal fluid and sodium retention in these patients.

Adolescent↗