Autologous bone-marrow transplantation for rheumatoid arthritis.
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Arthritis, Rheumatoid↗
Biomedical subjects
D R Langlands
Publications and source records attributed to D R Langlands.
SAPHO syndrome: a new pulmonary manifestation?
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Acne Vulgaris↗
Reactive arthritis associated with Clostridium difficile.
A case of reactive arthritis in a patient with a previously documented history of Reiter's syndrome is described. The precipitating agent appears to have been Clostridium difficile. High levels of toxin were demonstrable in the faeces and neutralising antitoxin was detected in the patient's serum but not synovial fluid. Resolution of the polyarthropathy was slow despite successful eradication of the C. difficile with a course of vancomycin.
Adult↗
Arthritis associated with a crystallizing cryoprecipitable IgG paraprotein.
A crystallizing IgG-lambda cryoprotein was found in the synovial fluid of a patient with peripheral erosive arthritis and tenosynovitis. The same crystallizing paraprotein could be demonstrated in serum incubated at 4 degrees C, but its formation could be inhibited by the in vitro addition of D-penicillamine. Crystals were present in synovial tissue and appeared to be initiating an inflammatory reaction via complement activation. Slit lamp examination showed crystals in Bowman's membrane. Plasmapheresis led to temporary improvement in the synovitis and tenosynovitis.
Arthritis↗
The value of immunofluorescence at the dermal/epidermal junction in connective tissue disorders.
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Adult↗