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Biomedical subjects

D R Levin

Publications and source records attributed to D R Levin.

At least 37 records · Page 2Linked to original sources
PubMed1989

Absence of peripheral-type benzodiazepine binding sites in renal carcinoma: a potential biochemical marker.

In an attempt to identify a tumour marker, we investigated peripheral-type benzodiazepine binding sites (PBS) in kidney specimens obtained from patients who underwent nephrectomy due to a renal mass. [3H]PK 11195, an isoquinoline carboxamide derivative, was used as a ligand. Binding assays were conducted on samples of membrane homogenate taken from both the healthy portion and the tumour site of the kidney. It was found that binding characteristics of benign tumours and normal kidney tissues were not significantly different, i.e. equilibrium dissociation constants of 2.20 +/- 0.73 and 2.38 +/- 0.98 nM, respectively, and maximal number of binding sites of 3190 +/- 1081 and 4189 +/- 998 fmol/mg protein, respectively. In contrast, no PBS were detectable in renal carcinoma. The absence of PBS in malignant renal tissues may serve as a biochemical marker for tumours of the kidney.

Adenoma↗
PubMed1989

Fracture of double-J ureteric stents: a report of two cases.

Two cases are reported of fracture of the double-J ureteric stent during its prolonged placement for extracorporeal ultrasound shock wave lithotripsy (ESWL). The causation of such fracturing is discussed and it is recommended that double-J stents employed in long-term ESWL be renewed within 5 months of their initial placement.

Adult↗
PubMed1989

Preoperative prediction of results of prostatectomy by a symptom score and radionuclide uroflowmetry.

A review of preoperative and postoperative symptom scores and radionuclide uroflowmetry in patients undergoing prostatectomy for benign prostatic hyperplasia indicates that there may be certain findings that can help to predict postoperative results. A statistically significant difference was obtained comparing the postoperative results of the symptom score and radionuclide uroflowmetry with the results obtained preoperatively. The correlation between the preoperative ejection fraction and the postoperative total symptom score and irritative score showed a good correlation.

Adult↗
PubMed1989

Lich-Gregoir anti-reflux operation: a surgical experience and 5-20 years of follow-up in 149 ureters.

The surgical management of vesicoureteral reflux and the choice between the many good procedures available continue to be debated by urologists. The goal of each procedure is to achieve as normal a function of the urinary system as possible, to eliminate urinary tract infections, and thus to prevent further kidney damage. We present our experience in 149 antireflux repair operations with a technique first described by Lich and Gregoir in 1961. The follow-up in this study is 5-20 years, throughout which recurrent infections, reflux and other operative complications have carefully been considered. The success rate of this operation was 92.5%, with an additional 3.75% success in repair operations. Discussion and evaluation of other repair methods are reviewed but, in our opinion the Lich-Gregoir technique, because of its simplicity, should be the method of choice and should be used more by urologists.

Child↗
PubMed1989

The use of distilled water as an irrigating fluid in patients undergoing transurethral resection of the prostate.

Thirty patients undergoing transurethral resection of the prostate using distilled water as an irrigating fluid were studied. There was no significant change in the serum concentration of the variables studied (preoperatively compared to postoperatively) as possible indicators of haemolysis or absorption of irrigating water such as sodium, potassium, albumin, total protein, creatinine, uric acid, urea, haemoglobin, haematocrit and haptoglobin. The mean value of plasma haemoglobin (P-Hb), observed immediately postoperatively and reflecting the magnitude of haemolysis, was delta 294.8 mg/l. There was a good correlation between P-Hb and the inflowing irrigating distilled water (r = 0.69). The P-Hb variation (delta) correlated with resection time and with the weight of the resected prostate (r = 0.54 and r = 0.52, respectively). A good correlation was also found between resection time and delta body weight which reflects the amount of water absorbed (r = 0.67) and between delta body weight and the inflowing irrigating water (r = 0.61). Our study shows that distilled water can be used as an irrigating fluid quite safely. The advantages of distilled water outweigh the disadvantages which can be avoided easily if proper attention is given.

Absorption↗
PubMed1989

Urinary retention due to catheter occlusion by worms.

Herein we report a very rare case involving acute occlusion of a Foley catheter by worms. The treatment consisted of removal of the occluded catheter followed by bladder washing with a Betadine solution mixed with normal saline and introduction of a new catheter.

Aged↗
PubMed1989

Quantitation of renal uptake of technetium-99m DMSA using SPECT.

Quantitative single photon emission computed tomography (SPECT) methodology based on calibration with kidney phantoms has been applied for the assessment of renal uptake of [99mTc]DMSA in 25 normals; 16 patients with a single normal kidney; 30 patients with unilateral nephropathy; and 17 patients with bilateral nephropathy. An excellent correlation (r = 0.99, s.e.e. = 152) was found between SPECT measured concentration and actual concentration in kidney phantoms. Kidney uptake at 6 hr after injection in normals was 20.0% +/- 4.6% for the left and 20.8% +/- 4.4% for the right. Patients with unilateral nephropathy had a statistically significant (p less than 0.001) low uptake in the diseased kidney (7.0% +/- 4.7%), but the contralateral kidney uptake did not differ from the normal group (20.0% +/- 7.0%). The method was especially useful in patients with bilateral nephropathy. Significantly (p less than 0.001) decreased uptake was found in both kidneys (5.1% +/- 3.4% for the left and 6.7% +/- 4.2% for the right). The total kidney uptake (right and left) in this group showed to be inversely correlated (r = 0.83) with serum creatinine. The uptake of [99mTc]DMSA in single normal kidney was higher (p less than 0.001) than in a normal kidney (34.7% +/- 11.9%), however, it was lower than the total absolute uptake (RT + LT = 41.5% +/- 8.8%) in the normal group. The results indicate that SPECT is a reliable and reproducible technique to quantitate absolute kidney uptake of [99mTc]DMSA.

Adolescent↗
PubMed1988

Primary giant calculus in urethral diverticulum.

Urethral stone is a rare clinical entity and usually encountered in men with urethral stricture or diverticulum. They are exceedingly rare in females secondary to the low incidence of vesical calculi and short urethra. We report a very rare case of a primary giant calculus in a urethral diverticulum of a female.

Aged↗
PubMed1988

Multifocal bleeding due to anticoagulant therapy.

A 62-year-old patient on anticoagulant therapy presented with hemothorax, pulmonary hemorrhages and a high retroperitoneal hematoma with obstruction-infarction of the right kidney. Following plasma infusion and pleural drainage, the clinical condition stabilized and kidney function improved.

Hematoma↗
PubMed1988

Paratesticular papillary mesothelioma.

A case of uncommon paratesticular mesothelioma in a young patient is presented. Its questionable malignancy, as well as the method of treatment are discussed.

Adult↗
PubMed1988

Effect of diclofenac sodium (Voltaren) on spermatogenesis of infertile oligospermic patients.

The effect of the prostaglandin synthesis inhibitor diclofenac sodium (Voltaren) on spermatogenesis in infertile oligospermic patients has been studied. Diclofenac sodium was given orally at a daily dose of 100 mg for 30 days. Seminal fluid parameters were evaluated. Group II with high levels of seminal prostaglandin showed a statistically significant increase in the number and motility of spermatozoa (p less than 0.01), whilst no significant variations were observed in patients of group I with normal values of seminal prostaglandin.

Adult↗
PubMed1987

Quantitative renal blood flow in urinary tract obstruction.

Technetium-labeled red blood cell scintigraphy using a bolus injection was used to obtain a noninvasive quantitative measurement of renal blood flow. The method used is an adaptation of the one used for calculating cerebral blood flow which involves deconvolution of the first pass of the isotope through the kidneys. The relative renal blood flow of 18 normal patients and 18 patients with unilateral urinary tract obstruction was performed. All patients with obstruction, but one, were reexamined after surgery. There was a significant difference between the normal and partially obstructed patients (p less than 0.001) and between those with partial and complete obstruction (p less than 0.01). After surgery a statistically observable improvement in the relative renal blood flow was obtained.

Adolescent↗