Biomedical subjects

D R Neilson

Publications and source records attributed to D R Neilson.

10 recordsLinked to original sources

PubMed1991

Glucose challenge testing in pregnancy.

This study examines results of routine glucose challenge screening in 608 third-trimester patients in a private practice setting. Four patient categories were defined on the basis of the results: normal, abnormal screen with normal glucose tolerance test, borderline glucose tolerance test, and gestational diabetes. When only standard prenatal management practices were used, the fetal outcomes in the four groups were not measurably different. The costs of these procedures resulted in an expenditure of $722.31 per diagnosis of gestational diabetes. This seems excessive in view of the negligible impact of these studies on fetal outcome. Our impression was that routine third-trimester dietary counseling, postprandial glucose monitoring without challenge testing, and evaluation of cases of suspected fetal macrosomia would result in comparable outcome at significantly reduced cost.

Adult↗

PubMed1989

Subclinical laminitis in dairy heifers.

By causing poorer horn quality, subclinical laminitis is considered to be a major predisposing cause of other hoof problems, particularly sole ulcers in newly calved heifers. In this study the hind hooves of 136 female Friesian/Holstein cattle aged between four months and two years were examined to discover at what age the signs of subclinical laminitis appeared. Sole haemorrhages were found in the hoof horn of calves as young as five months. The consistent finding of these lesions in heifers of all ages indicated that subclinical laminitis of varying degree was a common condition during the early growing period of young dairy heifers.

Age Factors↗

PubMed1986

Preinduction cervical ripening with sequential use of prostaglandin E2 gel.

Two hundred patients received a prostaglandin E2-containing gel for preinduction cervical ripening. The gel was administered every 6 hours until a Bishop score greater than or equal to 7 was obtained or the attending physician deemed induction necessary. Forty-eight percent of the patients labored "spontaneously" after one or more gel applications. The average cumulative change in Bishop score with sequential application of the gel was 2.7. Sequential application of the prostaglandin gel proved no more effective in the process of preinduction cervical ripening than single application of the gel with a similar period of observation.

Cervix Uteri↗

PubMed1983

A comparison of prostaglandin E2 gel and prostaglandin F2 alpha gel for preinduction cervical ripening.

The unfavorable cervix remains a major obstacle to the successful induction of labor. Reported are results from an ongoing study of topical prostaglandin preparations used to effect preinduction cervical ripening. The current study compares the efficacy of 40 mg of prostaglandin (PG) F2 alpha versus 5 mg of PGE2, applied to the cervix in a methyltylose gel the night before attempted induction of labor. A prospective double-blind protocol was used similar to that which previously established the efficacy of the 5 mg of PGE2 preparation versus placebo at this institution. Results indicate the superiority of the PGE2 preparation as measured by change in Bishop score, Pitocin requirement, rate of cervical dilatation, and percentage of failed inductions. Cesarean section rates were similar in the two study groups, and no fetal or maternal morbidity was attributable to the preinduction ripening technique.

Cervix Uteri↗

PubMed1983

Cervical ripening with intravaginal prostaglandin E2 gel.

Ripening of the cervix by intravaginal application of a prostaglandin-containing gel is evaluated. Thirty patients with an unfavorable cervix needing labor induction were studied in a double-blind, prospective fashion. The prostaglandin gel proved superior to placebo in ripening the cervix (P less than .05), reducing induction failures (P less than .025), diminishing the oxytocin dosage necessary for induction (P less than .05), and lowering the rate of cesarean section (.05 less than P less than .1). One hundred fifty additional patients with varying Bishop scores and differing clinical situations were also studied. There were 35 cesarean sections (23.3%), nine failed inductions (6%), a spontaneous labor rate of 46%, and an average Bishop score change of 2.5. Twenty patients with premature rupture of the membranes and an unfavorable cervix received a modified gel containing 2.5 mg of prostaglandin E2. Average Bishop score change was 2.9, and there was a 55% incidence of spontaneous labor.

Adult↗

PubMed1970