PubMed Health⌕ Search

Biomedical subjects

D R Pulitzer

Publications and source records attributed to D R Pulitzer.

36 records · Page 2Linked to original sources
PubMed1992

Compound (primordial) adnexal carcinoma arising in a systematized compound epithelial nevus.

A distinctive systematized epithelial nevus and associated multifocal carcinomas of the microcystic and sclerosing sweat duct type affected the lower extremities of a 9-year-old girl. The carcinomas were well differentiated and were both adenosyringomatous and microcystic. They qualify as microcystic and compound. In both the epithelial nevi and the carcinoma, primordial potentials are recapitulated.

Biopsy↗
PubMed1991

Histologic classification of the combined nevus. Analysis of the variable expression of melanocytic nevi.

The designation combined nevus gives recognition to mixed cytologic patterns. In the common variant, plump, pigmented spindle cells form fascicles among nests of ordinary nevus cells. In other variants, one or several cellular components that share cytologic features with either a blue nevus or a Spitz nevus are represented. Ninety-five cases, 49% of which were of the common type, were studied. Grossly, most of the lesions were darkly pigmented papules or nodules. The clinical diagnosis in three-fourths of the cases was nevus, blue nevus, or melanoma. Fifteen percent had concomitant histologic features of melanocytic dysplasia, and most of these lesions were of the common type. For the common variant, the cytologic features, pattern of apparent infiltration, and variable representation of the features of a premalignant melanocytic dysplasia often mislead a pathologist in interpreting and predicting biologic potential. In combined nevi, the phenotypic diversity and genetic lability of melanocytic nevus cells is manifested.

Adolescent↗
PubMed1990

Granular cell tumor of the breast.

Granular cell tumors are rare tumors occasionally located in the breast. They are generally benign, but can mimic breast carcinoma thus complicating diagnosis and treatment. The etiology of these tumors remains obscure, but may be neurogenic in origin. We report a case of granular cell tumor of the breast and present a review of the topic.

Aged↗
PubMed1990

Cutaneous vascular calcification with ulceration in hyperparathyroidism.

We report a histologically distinctive form of small blood vessel calcification that led to necrosis and ulceration of the skin. Microscopically, wedge-shaped ulcers of the skin and superficial subcutis were observed. Calcified deposits were identified in the walls of small blood vessels at the ulcer bases. Recanalized thrombi occluded the lumina of some of the calcified vessels. On the basis of these distinctive histologic findings, hyperparathyroidism was accurately predicted. These changes have previously been cited in the internal medicine and dermatology literature but, to our knowledge, not in the pathology literature. We believe that these lesions are not rare and are probably often overlooked by pathologists. The histologic and clinical findings in two cases are presented.

Adult↗
PubMed1989

Fibroma of tendon sheath. A clinicopathologic study of 32 cases.

We report 32 cases of fibroma of tendon sheath. Most cases presented as a painless mass in the distal portion of an extremity. Ganglion cyst was the most frequent clinical diagnosis. The median patient age was 30.5 years, and 60% of the patients were male. Only one lesion is known to have recurred. The lesions, which averaged 1.5 cm, were light tan, firm, and nodular. Histologic features common to all lesions were (a) a predominantly fibrous matrix containing (b) fibroblast-like spindle cells. Elongated, slitlike spaces were observed in many lesions, and nine cases had areas closely resembling nodular fasciitis. Myofibroblasts and fibroblasts were observed in the three cases studied by electron microscopy. The histologic findings were similar to those previously described for fibroma of tendon sheath. Although slitlike spaces are present in most instances, this finding is not specific for fibroma of tendon sheath, nor is it invariably present. Fasciitis-like changes have been noted in previous series. Our findings, as well as those from prior studies, indicate that fibromas of tendon sheath are heterogeneous. The diagnosis is made only after other fibrous, nodular lesions of the extremities are excluded. Fasciitis-like lesions heretofore classified as fibroma of tendon sheath are more appropriately classified as tenosynovial counterparts of nodular fasciitis.

Adolescent↗
PubMed1989

Ischemic intestinal necrosis as a cause of atypical abdominal pain in a sickle cell patient.

The authors present a case report of a sickle cell patient with end-stage renal disease treated with peritoneal dialysis who presented with abdominal pain. Although the pain was not unlike that typically associated with his crises, the absence of characteristic joint and chest pain made the diagnosis of "crisis" unlikely and favored the admitting diagnosis of peritoneal dialysis-related peritonitis. After the patient failed to improve with a medical regimen, including antibiotics, surgical consultation was obtained. Complete small bowel obstruction and diffuse peritonitis necessitated emergency surgery at which necrosis of terminal ileum was encountered. Histologic study of the resected specimen showed microvascular thrombosis with sickled erythrocytes. The authors review this rare complication and discuss the clinical problems of diagnosing typical and atypical abdominal pain in the sickle cell patient with and without concomitant crisis.

Abdominal Pain↗
PubMed1989

Pigmented myomatous neurocristoma of the uterus.

A tumor of the myometrium composed of pigmented and nonpigmented melanocytes in a matrix of altered smooth-muscle cells is reported. Electron microscopy and immunohistochemical studies were used to identify the cellular constituents. The neurocristic components were arranged in patterns comparable with those in cellular blue nevus of the skin. Problems relating to histogenesis and to taxonomy are addressed using neurocristic dysplasias of the skin as models. It is believed that melanin production should not be the only criterion used to classify pigmented neurocristic dysplasias arising in extracutaneous mesenchyme. The designation pigmented myomatous neurocristoma is proposed as a suitable alternative to cellular blue nevus To our knowledge, no similar lesion has been reported previously.

Adult↗
PubMed1988

Subcutaneous sacrococcygeal ("myxopapillary") ependymal rests.

Ependymal cell rests of the sacrococcygeal area are relatively common; they may occur in association with postcoccygeal (pilonidal) dimples or in the absence of observable abnormalities. Some of the lesions are poorly organized, whereas others closely resemble minute myxopapillary ependymomas. Most authorities believe that the majority of subcutaneous sacrococcygeal myxopapillary ependymomas arise in ependymal cell rests. Myxopapillary ependymomas may be locally aggressive and may metastasize, whereas ependymal rests are biologically indolent. We studied cutaneous ependymal rests of the sacrococcygeal region in four children to compare them with myxopapillary ependymomas of this anatomic site. All lesions were small (less than 0.5 cm) and were discovered incidentally in tissue from surgically corrected pilonidal sinuses. In no case was a mass lesion observed either clinically or upon gross examination of the excised specimen. Microscopically, the lesions consisted of clusters of ependymal cells near the junction of dermis and subcutis. Central vascular channels were surrounded by myxomatous material and rows of cuboidal cells, mimicking patterns seen in myxopapillary ependymomas. They differed from ependymomas in that they lacked characteristics associated with neoplasia--expansile, infiltrative, and destructive properties. Careful attention to histologic detail allows distinction of these lesions, which, though related, differ significantly in terms of prognosis.

Child, Preschool↗
PubMed1987

Mucoepidermoid carcinoma of the lacrimal gland. An oxyphilic variant.

Unlike their major salivary gland counterparts, mucoepidermoid carcinomas (MECs) of the lacrimal gland are extraordinarily rare. We report a case of an MEC of the lacrimal gland in which the majority of cells were oxyphilic. The patient, a 38-year-old woman, had been asymptomatic when an enlarged right lacrimal gland was detected. Histologically, the tumor was composed primarily of oxyphilic cells but focally exhibited characteristics diagnostic of MEC. To our knowledge, only two oxyphilic variants of MEC have been reported, and occurrence in the lacrimal gland has not previously been documented. The existence of this lesion is significant because it shares histologic features with oxyphilic adenoma (oncocytoma), a more common and less aggressive neoplasm of the orbit.

Adult↗
PubMed1987

Oncocytic pleomorphic adenoma of the parotid gland.

A rare case of salivary gland pleomorphic adenoma, in which the majority of cells were oncocytic, is reported. The patient, a 53-year-old man, presented with a parotid gland mass that was otherwise asymptomatic. Surgical treatment consisted of a superficial parotid lobectomy. The specimen was prepared in standard fashion and studied by light and electron microscopy. The microscopic features were characteristic of salivary gland pleomorphic adenomas, however, both epithelial and "mesenchymal" elements were oncocytic. Such changes may occur focally in pleomorphic adenomas, but we were unable to find documentation of a wholly oncocytic variant in a review of the medical literature. From our clinical data and previous reports of pleomorphic adenomas with focal oncocytosis, it is concluded that such changes likely do not alter prognosis in affected patients. The possible significance of this lesion in regard to the histogenesis of salivary gland pleomorphic adenomas is discussed.

Adenoma, Pleomorphic↗
PubMed1985

Tubuloalveolar adenoma of salivary gland.

An unusual monomorphic salivary gland adenoma, occurring in a 57-year-old woman, is described. The lesion was histologically similar to the so-called tubular adenoma; however, occasional microscopic foci of serous (acinar cell) differentiation were present. The term tubuloalveolar adenoma is proposed to describe salivary gland tumors that are histologically benign and composed of cells resembling those of normal intercalated ducts and secretory units (acini).

Adenoma↗
PubMed1985

Nerve-sheath myxoma (perineurial myxoma).

Seventy cases of nerve-sheath myxoma, an uncommon cutaneous neoplasm, are reported. Lesions developed most frequently on the face and upper extremities, and affected women about twice as often as men. Their average size was one centimeter. Histologically, the lesions involved the reticular dermis; many extended into the superficial portions of the subcutis. They were composed of fascicles of cells with interconnected cytoplasmic processes. The neoplastic cells were associated with variable amounts of a matrix that was rich in acid mucopolysaccharides. Mitoses were common, but evidently had no prognostic significance. Only one of 70 lesions was recurrent and no metastases are known to have occurred from any. For eight cases, immunoperoxidase staining for S-100 protein was done and all were positive. One lesion showed ultrastructural features of nerve-sheath cells, specifically perineurial cells.

Adolescent↗
PubMed1985

Embryonic implantation in carcinoma of the endometrium.

We recently encountered a patient in whom placental implantation occurred directly in carcinoma of the endometrium. At the time of surgery for a presumed tubal pregnancy, the 33-year-old patient was discovered to have bilateral ovarian tumors that were histologically identical to the endometrial neoplasm.

Adenocarcinoma↗
PubMed1984

Localized pigmented villonodular synovitis of the vertebral column.

We studied two patients with paravertebral localized pigmented villonodular synovitis. This anatomic location has not, to our knowledge, been previously described as a site for lesions of this type. In one case, a cervical paravertebral lesion first appeared clinically as a hypopharyngeal mass. The other lesion was noticed incidentally by a roentgenogram and had eroded bone in the lumbosacral area of the spine. We believed both lesions to have arisen from synovial membranes of the accessory joints of the vertebral column.

Adult↗
PubMed1982

Ossifying fasciitis.

Metaplastic bone is an uncommon finding in cases of fasciitis. It has been reported only in occasional cases in series of patients with nodular fasciitis, parosteal fasciitis, proliferative fasciitis, and proliferative myositis. Ossification is relatively common in cranial fasciitis of childhood, a form of fasciitis that may originate in cranial periosteum. We studied a patient with ossifying fasciitis that occurred along the adventitia of the femoral artery, at the site of an earlier angiographic study.

Adipose Tissue↗
PubMedDate not supplied

Xp microdeletion syndrome characterized by pathognomonic linear skin defects on the head and neck.

We describe a new case of a rare syndrome characterized by ocular abnormalities and pathognomonic linear skin defects. This syndrome is the result of an unbalanced translocation resulting in a deletion of the distal end of the short arm of the X chromosome. We report the thirteenth case and review the clinical and cytogenetic aspects of this disorder. In addition we discuss new findings pertaining to the histopathology of the skin lesions.

Abnormalities, Multiple↗