A review of absorption characteristics of microemulsion cyclosporine products over the last 2 years in Indian subjects.
Microemulsion based cyclosporine has demonstrated better absorption with lesser pharmacokinetic variability. For the clinical use of any new microemulsion based product, bioequivalence testing with existing formulation is necessary. Panimun Bioral (Test) and Sandimmun Neoral (Reference) were evaluated in different transplant centers using both volunteers as well as renal transplant patients. All these centers have reported that both products are bioequivalent. These reports offer the physician an option to convert the patients to the Test product for economic reasons.
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