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Biomedical subjects

D R Stone

Publications and source records attributed to D R Stone.

16 recordsLinked to original sources
PubMed1997

Necrotizing fasciitis. The changing spectrum.

Necrotizing fasciitis, by nature of its high inoculum of aggressive bacteria and the depth of the fascial involvement, is one of the most serious infections known to humans. Rapid tissue destruction of skin and fascia, along with bacteremia, is common. The mortality for this disease is much higher than that for cellulitis. Unfortunately, delay in diagnosis occurs commonly. The emergence of toxic shock strains of Streptococcus leading to fasciitis with organ dysfunction makes it necessary to make a rapid diagnosis and institute early antibiotic and surgical interventions.

Adult↗
PubMed1988

Lab-fraud anemia.

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Blood Chemical Analysis↗
PubMed1981

Adult body temperature and heated humidification of anesthetic gases during general anesthesia.

To determine the effects on body temperature of heating and humidifying inspired anesthetic gases to 37 C and 100% relative humidity, 42 men who had major surgical procedures under general anesthesia were studied. Group 1 (control) consisted of 10 patients who inspired gases from a standard semicircle absorber system with no added humidity. The mean nasopharyngeal temperature decreased significantly from 36.2 +/- 0.1 C to 34.9 +/- 0.2 C. Ten other patients, group 2, inspired gases that were heated and humidified. Mean nasopharyngeal temperature was maintained at 36.4 +/- 0.2 C with no significant changes throughout the study. One patient in this group became hypothermic, but only transiently. Ten patients, group 3, were allowed to become hypothermic before gases were heated and humidified. The mean nasopharyngeal temperature increased significantly from 34.7 +/- 0.2 C to 36.0 +/- 0.3 C during 4 hours of heated humidification. For groups 4 and 5, six patients each, gases were heated and humidified on alternate hours. The responses of the two groups demonstrated a causal relationship between the heating and humidifying of inspired gases and an increased mean nasopharyngeal temperature. It is concluded that heating and humidifying gases to 37 C and 100% relative humidity effectively maintains normothermia and rewarms hypothermic adults during general anesthesia.

Anesthesia, Inhalation↗
PubMed1979

Growth of hygroscopic aerosols in a model of bronchial airways.

Experiments have been performed on the "breathing" of micron-size hygroscopic aerosols in and out of a four-generation model of the bronchial tree. Comparison of the experimental results on aerosol growth in the model with the classical theory for dilute aqueous solutions of nonpolar salts shows a) that the theory is applicable to conditions in the airways, b) that to a high degree of approximation the process represents deposition followed by growth, and c) that there is a significant amount of trapping of particles near their equilibrium size in the deeper model tubes. These experiments are the first to verify that the classical particle growth theory is applicable to the particle sizes and environmental conditions present in the human airways during hygroscopic aerosol therapy. This theory will be useful in designing an optimal hygroscopic aerosol delivery system, but several questions including the method of generation and the effect of drug solutions on particle equilibriums remain to be answered.

Aerosols↗