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D R WOOD

Publications and source records attributed to D R WOOD.

At least 19 recordsLinked to original sources
PubMed1958

The release of adrenaline and noradrenaline from the adrenal medulla of the cat during splanchnic stimulation.

Cats were anaesthetized with chloralose, eviscerated and the right adrenal gland was removed. The venous outflow from the left adrenal gland was collected during 10 five-minute periods of stimulation of the left splanchnic nerve. The amounts of adrenaline and noradrenaline in the venous outflow and in the stimulated and unstimulated glands were determined by a fluorimetric method. In eight experiments a mean of 50.5 mug. of total catechol amine was recovered from the effluent blood. The mean difference in amine content between the stimulated and unstimulated glands was 50 mug., representing a loss of 29% from the stimulated gland. The proportions of the two amines in the effluent blood were very similar to those found in the gland. The results provide no evidence for an increase in the rate of synthesis of catechol amines during splanchnic stimulation.

Adrenal Glands↗
PubMed1958

Antithyroid activity of thiohydantoins.

The antithyroid activity of 2-thiohydantoin and some derivatives has been measured in rats, after a single dose and, also, after daily administration for 6 weeks. 2-Thiohydantoin and its 5-alkyl derivatives from 5-methyl to 5-sec-butyl- showed considerable antithyroid activity at a dose of 0.05 m.mole/kg. by mouth, but 5-n-hexyl-2-thiohydantoin had insignificant activity at this dose level. The presence of polar groups in the 5-substituent was associated with reduction or complete loss of activity. By the single-dose technique, 2-thiohydantoin was more potent than its 5-alkyl derivatives. The opposite result was obtained by other methods of assessment after 42 days of treatment. Some of the possible factors involved are discussed especially in relation to the difficulty of comparing results obtained by the different methods of assessment. The acute toxicity of 2-thiohydantoin and of its 5-methyl and 5-ethyl derivatives is reported. No toxic effects were found after daily administration of several 2-thiohydantoins at a dose of 50 mg./kg. for 6 weeks.

Animals↗