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Biomedical subjects

D Répássy

Publications and source records attributed to D Répássy.

At least 19 recordsLinked to original sources

[Urinary bladder and paraurethral endometriosis].

Authors report a case of bladder and a case of paraurethral endometriosis. The mode of sanitation was by means of TUR and surgery, respectively. Based on the available literary data, the assumptions related to development of the disease; its pathology, symptoms and treatment are discussed in brief. Despite the frequency of the disorder, exact diagnosis might take months, perhaps even years. Due to the difficulties in diagnosing this disease, correct diagnosis can be expected from biopsy, as in our case.

Adult↗

[Eosinophil cystitis].

Authors report on two rare cases of eosinophilic cystitis, giving a review of the etiologic assumptions and pathogenetic, pathologic aspects of the disease, based on the available literary data. The course of the disease can be either acute or subacute, and is most often chronic. Relapse and progression can interchange in irregular manner, attention is therefore called to the importance of follow-ups. Resection deep into the intact--also containing muscle fibre--as well as histologic examination are considered essential as the only method of differentiation, giving precise diagnosis in the present two cases, too.

Aged↗

[Schistosomiasis of the bladder].

Authors review a case of urinary schistosomiasis, where the process caused left sided urinary obstruction. Because of the suspicion of a tumor transurethral resections was performed, where after the ureter passage became unhindered. Diagnosis became clear upon the histological examination of the resected tissue. Based on the cited literature, reference is made to the mortality rate of the disease in the expanded endemic areas, as well as to the high number of patients at risk. A brief summery is given of the pathology, symptoms, diagnostics of the disease, with mention of differentiation and therapeutic possibilities as well. With regard to importation of the disease, attention is called to the importance of careful anamnesis.

Adult↗

[Retroperitoneal malignant fibrous histiocytoma].

Authors review the case history and follow-up of a rare malignant fibrous histiocytoma patient, based on the relevant literary data. The tumor filled the retroperitoneum on the right side, in front of the right kidney. Intravenous urography and computer tomography revealed a 10 x 15 cm sized mass, suspect of being a kidney tumor. Upon surgery, the tumor was found to be a retroperitoneal malignant fibrous histiocytoma. In connection to the case, a brief review is given of the storiform type of malignant fibrous histiocytoma, regarding its etiological, clinical and pathological aspects, the difficulties in diagnosis, as well as the therapeutic possibilities. Authors regard their case worthy of publication because of the retroperitoneal location and significant size of the tumor, and because of the unproven diagnosis prior to surgery. Even after 4 years the patient is symptom- and complaint-free, and CT has revealed no metastases.

Aged↗

Retroperitoneal malignant fibrous histiocytoma.

Authors review the case history and follow-up of a rare malignant fibrous histiocytoma patient, based on the relevant literary data. The tumour filled the retroperitoneum on the right side, in front of the right kidney. Intravenous urography and computer tomography revealed a 10 x 15 cm sized mass, suspect of being a kidney tumour. Upon surgery, the tumour was found to be a retroperitoneal malignant fibrous histiocytoma. In connection with the case, a brief review is given of the storiform type of malignant fibrous histiocytoma, regarding its aetiological, clinical and pathological aspects, the difficulties in diagnosis, as well as the therapeutic possibilities. Authors regard their case worthy of publication because of the retroperitoneal location and significant size of the tumour, and because of the unproven diagnosis prior to surgery. Even after 4 years the patient is symptom- and complaint-free, and CT has revealed no metastases.

Aged↗

[Renal oncocytoma].

Authors review the case history of three patients with kidney tumours which had been surgically removed. In two of the cases radical nephrectomy while in one, organ-preserving surgery was performed. In all three cases histology revealed benign kidney tumours-oncocytomas. In light of the available literature authors indicate that preoperative diagnosis is almost impossible. Furthermore, it is their opinion that this benign kidney tumour has a less frequent occurrence than earlier thought.

Adenoma, Oxyphilic↗

Prostatic leiomyosarcoma.

The histopathological findings from the third prostate operation of a 63-year-old patient proved that his leiomysarcoma was malignant. Leiomyosarcoma is a disease of low incidence. Of 1000 cases of a carcinoma of prostate one proves to be this disease. Its clinical distinction from benign prostate disease meets difficulties. A survey of literature has shown that even multiple aggressive therapy fails when the process has overpassed the limits of the organ. Early diagnosis followed be radical pre- and postoperative X-irradiation may lead to long-term survival. Neither cytostatic nor hormonal therapy is successful. The course of the illness of our patients merits interest because of the rarity of the disease and the diagnostic difficulties.

Humans↗

Spontaneous (renal) pelvic rupture. Two cases cured by conservative therapy.

Two cases of spontaneous pelvic rupture are presented. In Case 1 (female, 49 years) and Case 2 (male, 63 years) the rupture was due to obstruction and tumorous compression of the ureter, respectively. Authors deal with the diagnostic difficulties and the possibility of a cure without open surgery. Conservative therapy (double-J ureteral catheter and pigtail catheter) was successful in both cases. The pertinent literature is briefly reviewed.

Catheterization↗

Ureter and bladder replacement following radical cystectomy.

During the course of Hautmann-type bladder replacement, left sided ureter damage necessitated ureter replacement as well, modifying the removal of the ileum-bladder. The proximal 20 cm length of the 70 cm long isolated ileum portion was not detubularized; instead it was slipped through the mesosigma and mesocolon to the left side of the colon and the left ureter stub was anastomized without tautness to the ileum according to Le Duc. The implantation of the right ureter was accomplished according to Hautmann. For similar cases authors recomment this procedure, since neither stricture, nor reflux could be detected at later examinations.

Aged↗

Organ-preserving surgery of renal cell carcinoma: report of four cases.

Authors removed the renal tumour of four patients by means of resection in an organ-preserving manner. Of the four patients, one had bilateral carcinoma. The right-sided carcinoma of this patient was removed by resection while the other kidney was removed radically, by transabdominal approach. In three of the four cases which were in the process of stages T1 and N0M0, organ-preserving surgery was performed in the presence of intact opposite kidneys. Authors point out the fact that the resection method might be indicated even in the case of early (T1) stage tumours with intact opposite side kidneys. Furthermore, they do not recommend the enucleation of renal carcinomas for the surgical treatment of kidney tumours, since experimental studies have proved that these tumours can be transferred into the parenchyma of the kidney through the pseudocapsule of the tumour.

Adenocarcinoma, Clear Cell↗

Bilateral ureteric replacement with ileum.

In connection with a report of a case, authors discuss in outline the possibilities of ureter replacement. If both the ureters are injured, they can be substituted with one single segment of the intestine, as it happened in their case. Authors raise the idea that a longer segment of the intestine used for substitution provides sufficient capacity and isoperistaltic function, and this may protect from the negative effects of possible vesicoileal reflux. In this case, the reflux does not spread to the kidneys even if the ureteroileal was not made with anti-reflux technique.

Anastomosis, Surgical↗

Kidney oncocytoma.

Authors review the case history of three patients with kidney tumours which had been surgically removed. In two of the cases radical nephrectomy while in one, organ-preserving surgery was performed. In all the cases histology revealed benign kidney tumours--oncocytomas. In light of the available literature authors indicate that preoperative diagnosis is almost impossible. Furthermore, it is their opinion that this benign kidney tumour has a less frequent occurrence than earlier thought.

Adenoma, Oxyphilic↗

Alterations of glycosaminoglycans in human liver and kidney tumors.

Glycosaminoglycans were investigated in surgically removed human liver and kidney tumours by applying biochemical methods. Four liver adenoma, 6 focal nodular hyperplasia and 9 primary hepatocellular carcinoma samples were compared with normal liver from autopsy cases and also with liver tissue adjacent to PHC. The studies on kidney included 14 renal cell carcinoma and 4 wilms' tumour samples. Three findings emerged from the quantitative and qualitative characterization of the tumours with epithelial origin. 1) The rise in the amount of total GAG was not limited to the malignant lesion. Similar increase was observed in benign liver tumours and also in the tissue adjacent to liver or kidney malignant tumours. 2) The dominant type of the GAG subclasses varies with the histology of the tumours. In benign liver tumours dermatan sulfate, in PHC and renal cell carcinoma chondroitin sulfate, but in Wilms' tumour hyaluronate was the prominent GAG subclass. 3) In all tumour-affected tissues dermatan and chondroitin sulfates had lower degree of sulfation. However, in the histologically different tumours various disaccharides showed reduced level of sulfation. The GAG alteration in renal cell carcinoma was compared with the prognostic factors of each individual case. This analysis showed a good correlation between HS/CS ratio and the prognostic factors of the kidney tumour cases.

Chromatography, High Pressure Liquid↗

Radical nephrectomy through total median laparotomy.

Twenty-two carcinoma patients aged less than 65 years were subjected to radical nephrectomy through total median laparotomy. This type of approach provides excellent access to both essential operation phases: vessel management and lymphadenectomy. Postoperative abdominal complications and hernia have not been encountered.

Adult↗

Observations with Depo-Provera (medroxyprogesterone) in the management of renal tumours.

A total of 30 patients with renal tumours were started on Depo-Provera (medroxyprogesterone) in December 1981 and followed up for 17 to 44 months. The survivors were checked in July 1985. In 2 of the 13 metastasis-free patients deposits of lethal outcome had formed, survival time averaging 27 months. One of the 8 patients with local metastases had died of renal tumour, average survival time being 26 months. Among the 9 patients with distant metastases there are 2 with survival times of 42 and 44 months, respectively. The liver metastases confirmed by ultrasonography in the first, and in the vena cava in the second case at the time of surgery are no longer demonstrable. Survival time in the last-named group averages 14.5 months.

Adult↗

Immune studies by the use of Multitest-Merieux in patients with kidney tumours.

Responsiveness to recall antigens was studied by the use of Multitest-Merieux in 20 cases of kidney tumour with and without deposits. The patients of either group, compared with the controls, had depressed scores of immunoreactivity. After surgical removal of the tumour-bearing kidney, immunoreactivity increased, regardless of the presence or absence of deposits. The number of reacting antigens also increased in every case. Lymphocyte transformation in vitro was also depressed, in comparison with the controls before surgery, but after the intervention the transformed blast cells increased in number. Multitest was found suitable for studies of delayed-type sensitivity.

Adult↗

Renal cell carcinoma--xenotransplantation into immuno-suppressed mice.

21 human renal cell carcinomas (RCC) were xenotransplanted into artificially immunosuppressed mice. 4 tumors grew successfully retaining some characteristics of the primary tumors (according to morphology and karyotype analysis), but losing metastatic capacity. One of the serially transplantable tumors (HT 40) with hyperdiploid cellular DNA content and estrogen receptor positivity failed to respond to the single maximally tolerated dose of several cytotoxic agents.

Adenocarcinoma↗