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Biomedical subjects

D Röhl

Publications and source records attributed to D Röhl.

At least 19 recordsLinked to original sources

[Spontaneous remission of Goodpasture syndrome in a 21-year-old patient].

HISTORY AND CLINICAL FINDINGS: A 21-year-old man was admitted twice within half-a-year because of fatigue and increasing dyspnoea. Both times the chest x-ray showed extensive pulmonary infiltrates. Clinical remission occurred within a few days of starting antibiotic treatment. INVESTIGATIONS: During the second admission an increased titre for antibodies against glomerular basement membrane was discovered (2560 U/ml); renal functions were normal, but there was haematuria. Renal biopsy revealed linear deposits of IgG along the glomerular basement membrane. DIAGNOSIS, TREATMENT AND COURSE: The pattern of findings indicated Goodpasture's syndrome. Immunosuppressive treatment and plasma separation did not have to be performed because spontaneous remission occurred within a few days. CONCLUSION: This case demonstrates that spontaneous remission may occur in Goodpasture's syndrome.

Adult↗

[Diagnosis of acute coronary ischemia].

In patients presenting with acute chest pain and suspected acute coronary insufficiency the diagnosis and the decision to admit such patients to a coronary care unit is based on the history, the physical findings and the first electrocardiogram. A diagnostic flow diagram can complement but not substitute clinical judgement.

Angina Pectoris↗

[Molsidomine in ergometric tests (author's transl)].

The effect of 2 mg sublingual molsidomine was evaluated in a double-blind cross-over study and compared to placebo in 9 patients with stable angina pectoris and ST-lowering of greater than or equal to 1 mm in the exercise ECG. Assessment of exercise tolerance (Watt-minute product) and ST-lowering during exercise with the bicycle ergometer was correlated with simultaneously measured blood plasma levels. An increase of maximal Watt-minute product from mean = 308.3 (s mean - 45.4) to mean = 74.4 (s mean = 138.7) was found after 1 hour with effectiveness over 5 hours. ST-lowering while on molsidomine was decreased from mean = 2.5 mm (s mean = 0.3) to a minimum of mean = 0.7 mm (s mean = 0.28) during identical work load. Action on the ST segment lasted for 3 hours. Blood plasma levels of molsidomine correlated to the drug action with a maximum after one hour and a half life of 2.03 hours.

Angina Pectoris↗