Biomedical subjects

D Raskovic

Publications and source records attributed to D Raskovic.

3 recordsLinked to original sources

PubMed2004

Permanent repigmentation of piebaldism by erbium:YAG laser and autologous cultured epidermis.

BACKGROUND: Several surgical techniques have been proposed for the treatment of piebaldism. These procedures, however, are poorly suited for the treatment of large leucodermal lesions, can cause scars and require multiple donor sites. Recently, it has been reported that autologous cultured epidermis induces scarless repigmentation of large vitiligo lesions, using a single small donor site. OBJECTIVES: To induce permanent repigmentation of large achromic lesions in patients suffering from piebaldism by means of autologous cultured epidermal grafts using a rapid, simple and non-invasive surgical procedure. METHODS: Six patients with piebaldism were enrolled in this study. Achromic epidermis was removed by means of appropriately set erbium:YAG laser and autologous cultured epidermal grafts were applied on to the recipient bed. Melanocyte content was evaluated by 3,4-dihydroxyphenylalanine reaction. The percentage of repigmentation was calculated using a semiautomatic image analysis system. RESULTS: Autologous cultured epidermis, bearing a controlled number of melanocytes, induced repigmentation of all piebald lesions. The mean percentage repigmentation was 95.45% (2791.5 cm2 repigmented/2924.2 cm2 transplanted). CONCLUSIONS: Autologous cultured epidermal grafts induce permanent and complete repigmentation of piebald lesions, in the absence of scars. Erbium:YAG laser surgery is a rapid and precise tool for disepithelialization, hence allowing treatment of large piebald lesions during a single surgical operation.

Adolescent↗

PubMed2001

Patient monitoring using personal area networks of wireless intelligent sensors.

A wearable device for monitoring multiple physiological signals (polysomnograph) usually includes multiple wires connecting sensors and the monitoring device. In order to integrate information from intelligent sensors, all devices must be connected to a Personal Area Network (PAN). This system organization is unsuitable for longer and continuous monitoring, particularly during the normal activity. For instance, monitoring of athletes and computer assisted rehabilitation commonly involve unwieldy wires to arms and legs that restrain normal activity. We propose a wireless PAN of intelligent sensors as a system architecture of choice, and present a new design of wireless personal area network with physiological sensors for medical applications. Intelligent wireless sensors perform data acquisition and limited processing. Individual sensors monitor specific physiological signals (such as EEG, ECG, GSR, etc.) and communicate with each other and the personal server. Personal server integrates information from different sensors and communicates with the rest of telemedical system as a standard mobile unit. We present our prototype implementation of Wireless Intelligent SEnsor (WISE) based on a very low power consumption microcontroller and a DSP-based personal server. In future we expect all components of WISE integrated in a single chip for use in a variety of new medical applications and sophisticated human computer interfaces. Existing growth of wireless infrastructure will allow a range of new telemedical applications that will significantly improve the quality of health care.

Computer Communication Networks↗

PubMed2001

Thermistor-based breathing sensor for circadian rhythm evaluation.

One of the most frequently used methods to sense breathing pattern is to detect airflow using a nasal thermistor or a thermocouple sensor. Prolonged, minimally intrusive measurement of the breathing pattern is particularly important for polysomnography, sleeping disorders, stress monitoring, biofeedback techniques, and circadian rhythm analysis. Although most applications require only breathing pattern, some applications and diagnostic procedures require monitoring of the rhythm of change of dominant nostril. In this paper we present our design of a differential thermistor-based breathing sensor for prolonged monitoring during the normal activity. The system is designed using a low power microcontroller Texas Instruments MSP430F149 with an on-chip A/D converter for data acquisition and signal processing. We use wireless RF link to a PC for long-term data acquisition and storage. Precise measurement requires decreasing zero and sensitivity errors of the measurement. We discuss signal processing methods, calibration and parameters used to characterize breathing patterns necessary for circadian breathing rhythm evaluation.

Circadian Rhythm↗