PubMed HealthSearch

Biomedical subjects

D Read

Publications and source records attributed to D Read.

44 records · Page 3Linked to original sources

Fusiform basilar artery aneurysm in a child.

A giant fisuform basilar artery aneurysm ruptured, causing the death of an 11-year-old girl who had presented with a 5-month history of headaches and a 1-month history of progressive brainstem features with choreiform movements. This case, unlike other reported cases, demonstrated no evidence of a generalized arteriopathy, and draws attention to the occurrence of this rare cause in the differential diagnosis of progressive brainstem syndrome in children.

Basilar Artery

Peripheral neuropathy and solitary plasmacytoma.

Three patients with peripheral neuropathy and a solitary plasmacytoma are presented, and the literature is reviewed. It is suggested that middle-aged men with an obscure progressive sensorimotor neuropathy, a raised CSF protein, and otherwise negative investigations should have a full skeletal survey since irradiation of a plasmacytoma may lead to a considerable improvement in the associated neurological disability.

Adult

Neurotensin metabolism in the rat: contribution of the kidney.

The kidney plays a key role in the metabolism of neurotensin (NT). We have examined the renal mechanisms of NT clearance by measuring plasma NT basally and after 45 min infusion of NT(1-13) in intact rats, anephric rats (no glomerular filtration, no peritubular metabolism) and ureteral ligated rats (reduced filtration). Plasma NT was measured by radioimmunoassay with both C (biologically active end) and N terminal directed antisera. In anephric and ureteral ligated rats, basal plasma NT like immunoreactivity measured with either antisera was increased 3-fold compared with unoperated rats. C terminal concentrations were higher than N indicating that a C terminal variant of NT was present in basal plasma. Infusion of NT(1-13) increased N terminal NT from 36 +/- 3 to 249 +/- 35 pmol/l (p less than 0.01) in unoperated rats with significantly larger increases in the renally compromised groups. This was reflected in the reduced metabolic clearance rates (measured with the N terminal directed antisera) in the anephric (16 +/- 1 ml/kg/min) and ureteral ligated (17 +/- 3 ml/kg/min) rats when compared with the control rats (26 +/- 4 ml/kg/min). The similar reductions in the anephric and ureteral ligated rats suggested that the decrease in N terminal NT metabolism was from the absence of filtration. Infusion of NT did not increase C terminal NT immunoreactivity in intact, anephric and ureteral ligated rats showing that the C terminal end was extremely labile. However when endogenous converting enzyme activity was blocked by captopril administration there was a significant increase in C terminal immunoreactivity suggesting a role for converting enzyme like proteases in the clearance of the biologically active end of NT.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals

Characterization of neurotensin(6-13) from an hepatic fibrolamellar carcinoma.

Neurotensin(6-13) has been isolated and sequenced as the major form of neurotensin-like immunoreactivity (NTLI) in a human hepatic fibrolamellar carcinoma. Circulating NTLI in the patient, especially C-terminal, was very high. In additional studies, NT(6-13) was synthesized and compared with the purified tumor NTLI by HPLC analysis and by testing stability in plasma in vitro. These methods confirmed that the tumor NTLI was identical to NT(6-13). Since the metabolic clearance rate of synthetic NT(6-13) in sheep was 30-fold higher than NT(1-13), it suggests that the elevated plasma levels are the result of impaired clearance and/or markedly elevated production.

Adult

Experimental reproduction of Mycoplasma gallisepticum disease in chukar partridges (Alectoris graeca).

An outbreak of conjunctivitis and severe respiratory disease occurred in an integrated chukar partridge (Alectoris graeca) operation that involved about 8000 birds. The main clinical features were conjunctivitis and sinusitis and frequent mouth breathing, but almost no gasping or coughing. In 1000 breeders, egg production declined from 73% to 20%. Morbidity reached 100%, and losses from mortality and culling approached 60%. At necropsy, a conjunctivitis (often bilateral) and extensive caseated sinusitis were common. There was an occasional slight mucoid tracheitis, but no significant air sac lesions were noted. Mycoplasma gallisepticum, designated strain GM1125, was isolated and identified. Exposure of susceptible chukars to GM1125 reproduced the field disease. GM1125 was reisolated from the conjunctiva of all exposed birds 12 days postinfection, but infrequently from there or the respiratory system 36 days postexposure, even though clinical disease was still present. The experimental disease was confined to the conjunctiva and the upper respiratory tract. An occasional mucoid tracheitis was noted, but generally, the lungs and air sacs were not involved. Infection was followed by an appreciable serological response to M. gallisepticum.

Animals