Biomedical subjects
D Riley
Publications and source records attributed to D Riley.
Why older age predicts lower acceptance of physician-assisted suicide.
BACKGROUND: Prior research has shown that older Americans have less accepting attitudes toward the legalization of physician-assisted suicide (PAS). OBJECTIVE: The current study tests nine explanations for why older Americans are less accepting of PAS. DESIGN: Survey questionnaires in two settings: a small rural community and an internal medicine clinic in western Wisconsin (n = 1,311). RESULTS: Overall, 57% of this sample supported legalization of PAS while 31% opposed and 12% were in the middle. Two of the nine factors significantly (and negatively) predicted attitudes toward PAS: religious beliefs and belief that life's transitions have value. One factor is shown to mediate the relationship between age and PAS. Older subjects' greater focus on religious beliefs was able to significantly explain their lower levels of acceptance of PAS, as compared to younger subjects. CONCLUSION: Findings from this study support other PAS studies, which indicate that most Americans support the legalization of PAS. More importantly, it clarifies the role of age--that is, age is not important in and of itself. Rather, it is important as a predictor of religious beliefs which in turn predict negative attitudes and unique influences on the thinking of American adults concerning the legalization of PAS.
Health care in big cities--the McGill experience.
Big cities encounter problems which are peculiar to them: population mix, housing conditions, social structure, infrastructure including transport, etc, which manifest in hospitals. From the beginning of the 20th century, big cities have been served by many providers of hospital care. Common to most cities is the change in the principles and methods of care, e.g. home care, and the notion that traditional hospital services are no longer the only answer to the needs of the population of large cities. Over the last decade, plans and projects have been devised to address the problems of excessive bed capacity, insufficient and excessive specialised units and difficulties in administration of payment systems.
Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer.
Several methods have been used recently to determine gene expression profiles of cell populations. Here we demonstrate the strength of combining two approaches, serial analysis of gene expression (SAGE) and DNA arrays, to help elucidate pathways in breast cancer progression by finding genes consistently expressed at different levels in primary breast cancers, metastatic breast cancers, and normal mammary epithelial cells. SAGE profiles of 21PT and 21MT, two well-characterized breast tumor cell lines, were compared with SAGE profiles of normal breast epithelial cells to identify differentially expressed genes. A subset of these candidates was then placed on an array and screened with clinical breast tumor samples to find genes and expressed sequence tags that are consistently expressed at different levels in diseased and normal tissues. In addition to finding the predicted overexpression of known breast cancer markers HER-2/neu and MUC-1, the powerful coupling of SAGE and DNA arrays resulted in the identification of genes and potential pathways not implicated previously in breast cancer. Moreover, these techniques also generated information about the differences and similarities of expression profiles in primary and metastatic breast tumors. Thus, combining SAGE and custom array technology allowed for the rapid identification and validation of the clinical relevance of many genes potentially involved in breast cancer progression. These differentially expressed genes may be useful as tumor markers and prognostic indicators and may be suitable targets for various forms of therapeutic intervention.
Chlamydia trachomatis as a significant cause of sterile pyuria.
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Attempts to detect parasitic causes of diarrhoea.
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Attempts to detect parasitic causes of diarrhoea.
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Maximising the detection of bacterial enteric pathogens.
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Forecasting patient services: a 21st century vision of an academic health centre.
This article provides an overview of the development and implementation of the McGill University Health Centre model for forecasting patient services in the year 2004, and advice on how to apply the model. Critical success factors and case examples are highlighted. The insights provided will be of value to hospitals and other institutions that recognize the necessity of engaging in long-range planning and forecasting.
Absorption of subpicosecond UV laser pulses during interaction with solid targets.
The absorption of subpicosecond uv laser pulses has been measured at intensities above 10(17) W/cm(2). High levels of absorption were observed, up to 55% for s polarization and 65% for p polarization. The behavior with angle of incidence and polarization can be interpreted as due to a combination of resonance and collisional absorption, taking place in a plasma with a scale length of the order of a fraction of the laser wavelength.
Harm reduction: concepts and practice. A policy discussion paper.
This paper provides an overview of the context, definition, and key features of the harm reduction approach, and provides several examples of current programs in various countries. Both licit and illicit drugs are included in these illustrations. Some of the critical issues, and the strategies needed to advance harm reduction, are discussed. [Translations are provided in the International Abstracts Section of this issue.]
Synthesis and antibacterial activities of novel 12-O-methylerythromycin A derivatives.
The novel erythromycin A derivatives: 9(S)-9-dihydro-12-O-methylerythromycin A (6) and 12-O-methyerythromycin A (3), have been prepared using a new synthetic approach. The critical step is the regioselective methylation of the 12-hydroxyl of the boron complex of 2',4"-O-bis(trimethylsilyl)-9(S)-9-dihydroerythromycin A (8), which has unprotected 6-, 9- and 11-hydroxyl groups. The antibacterial activities of these new derivatives were compared with those of erythromycin A (1), clarithromycin (2) and 9(S)-9-dihydroclarithromycin (5).
Concerns about run-in periods in randomized trials.
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Methicillin-resistant S. aureus in the suburbs.
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Is levodopa toxic to human substantia nigra?
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Secondary adrenal failure in a young woman presenting as hypoglycaemic coma.
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Resistant Streptococcus pneumoniae in the community.
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First Measurement of the B--> pi l nu and B--> rho ( omega )l nu Branching Fractions.
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