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Biomedical subjects

D Rościszewska

Publications and source records attributed to D Rościszewska.

At least 19 recordsLinked to original sources
PubMed2000

[Secretion of catecholamines in urine of patients with tonic-clonic epileptic seizures].

UNLABELLED: Epileptic seizures are concerned with temporary neuronal activation of adrenal medulla, manifested by increase of adrenaline and noradrenaline concentration in plasma and clinical symptoms as, among others, an increase in blood pressure, tachycardia and temporary hyperglycaemia. This adrenergical activation may be probably due to reactivity changes in adrenal-sympathetic system in patients with epilepsy also in interseizure periods. AIM: Evaluation of adrenaline, noradrenaline and dopamine excretion in 24-hour period urine collection in epileptic patients and examination, if there is a correlation between epilepsy clinical picture and catecholamines urine elimination. MATERIAL: 32 epileptic patients (16 women, 16 men) in mean age 31.1 +/- 7.1 and 29 healthy age-matched subjects in control. The age of falling ill, disease duration, etiology, family history, type and frequency of seizures, results of neurological and EEG examinations and the applied treatment, have all been taken into account in epilepsy clinical picture. METHOD: Daily urine collection was performed on a day-off, and time lapse since the last epileptic seizure was at least 48 hours. Quantitative determination of adrenaline, noradrenaline and dopamine in urine was performed by fluorimetric method. Differences among the obtained values were compared by t-Student's test, additionally, correlation coefficient was calculated. RESULTS: Significantly lower mean quantities of dopamine excreted within 24 hours in the whole group of epileptic patients and no significant differences in adrenaline and noradrenaline excretion were found, in relation to control group. Differences in catecholamines excretion in some cases occurred, in correlation with epilepsy clinical picture (onset of epilepsy, results of neurological and EEG examination, phenytoin treatment). CONCLUSIONS: Obtained results suggest the reactivity disturbance of dopamine-noradrenaline-adrenaline system in the epilepsy course. It may result in changes of catecholamines, especially dopamine, excretion with urine.

Adult↗
PubMed1997

[Triiodothyroxine (T3), thyroxine (T4), thyreotropine (TSH) and myoglobin levels in patients with myasthenia gravis].

T3, T4, TSH and myoglobin levels were determined in 14 patients with myasthenia gravis and compared with thirty one healthy control subjects. Significant decrease of myoglobin concentration and increase T3, T4 levels as compared to control group was found. TSH concentration was in normal range. Duration of myasthenia, level of disease (according to Osserman classification) and kind of therapy not influenced on detectable variations myoglobin, T3, T4 and TSH concentration.

Adult↗
PubMed1996

[Influence of hemodialysis on changes in cerebral artery blood flow velocity in patients with chronic renal failure].

The effect of hemodialysis on the cerebral circulation have been inadequately studied. Because of repeatability, safety and non-invasiveness transcranial Doppler sonography is well suited for evaluation of cerebral circulation and for estimation of cerebral blood flow during hemodialysis as well. The aim of our study was to find out whether hemodialysis affects the velocity of blood flow in extra- and intracranial arteries and in what way. 41 patients aged 18-71 (mean 43.9 +/- 13) years suffering from chronic renal failure made up the investigation group. We investigated 17 men and 24 women. Doppler examination was done to each dialized patient immediately before and then 120 and 240 minutes after the onset of hemodialysis. We used pulsed wave Doppler (TC2-64B, EME). Mean blood flow velocities were obtained from extracranial (CCA, ICA, ECA) and intracranial vessels (MCA, ACA, PCA). Simultaneously the series of biochemical blood parameters and arterial blood pressure were monitored. On the basis of investigation results the following conclusion have been drawn: Hemodialysis significantly affects on changes of blood flow velocities in extra-an intracranial arteries. Above mentioned changes consist in decrease of blood flow velocity in both CCA, left ICA, both MCA and PCA and right ACA.

Adolescent↗
PubMed1995

Hemiplegic migraine with CSF abnormalities.

A 30-year-old woman with hemiplegic migraine and an elevated CSF protein level with considerable pleocytosis is described. Fourteen other cases of hemiplegic migraine with cerebrospinal fluid abnormalities reported in the literature are reviewed.

Adult↗
PubMed1994

[Level of myoglobin in serum of patients with epilepsy after generalized tonic-clonic seizure].

In 11 patients with epilepsy serum myoglobin level determinations were performed by the RIA method 10 minutes, 1 hour, 4, 12, and 24 hours after tonic-clonic seizure and were compared with myoglobin concentrations in a group of 30 healthy persons. A statistically significant increase of myoglobin concentration was shown already in the first hour after the seizure with maximal level, almost five times exceeding the baseline level in the fourth hour, and slightly lower--four times exceeding the baseline--12 hours after the seizure. The correlative studies, comparing the profile of myoglobinaemia with the clinical picture (duration of the disease, age and sex, presence or lack of EEG changes, type of therapy used) showed no statistical significance.

Adult↗
PubMed1988

Adrenal cortex hormones in male epileptic patients before and during a 2-year phenytoin treatment.

Serum levels of progesterone, cortisol and phenytoin as well as the excretion of 17-OHCS were determined in 45 male epileptics before and during 24 months of the therapy. A significant decrease of the hormones was found in untreated patients. Phenytoin administration caused further decrease of cortisol and its metabolite 17-OHCS levels and a compensation of progesterone serum concentration.

17-Hydroxycorticosteroids↗
PubMed1986

Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy.

The excretion of three oestrogen fractions and progesterone metabolites in 64 female epileptic patients was determined during the menstrual cycle, and in 50 women of this sample serum phenytoin and phenobarbitone levels were measured. A significant decrease of both hormones in epileptic patients was found as compared to a control group. The variations in serum phenytoin levels were greater in females with so-called catamenial epilepsy with a marked fall of drug levels between days 27 and 28 corresponding with an increase of seizure frequency. The effect of progesterone deficit on seizure susceptibility before menstrual bleeding is discussed, and the need of serum anticonvulsant level determination during the premenstrual phase in epileptic women is suggested.

Adolescent↗
PubMed1980

Analysis of seizure dispersion during menstrual cycle in women with epilepsy.

The correlation between seizures and menstrual cycle was studied in 69 females with epilepsy, mean age 28.7 years. Between 1975-1978 the patients had registered in standard diaries data of menstruation and seizures. Altogether 1237 complete menstrual cycles were collected with 6900 registered seizures. The computer analysis showed a significant increase of seizures frequency in the second phase of cycle with the peak on the first day of menstruation. During 7 days before menstrual bleeding 2137 seizures were noted while during 7 days after menstruation 1476 fits were registered. In 58% of cases the frequency of seizures increased during premenstrual phase, in 9% during menstruation and in 33% the influence of menstrual cycle was not observed. In the group of women with seizures related to menstrual cycle the course of epilepsy was worse, the premenstrual tension syndrome was present more often and cycles were prolonged as compared with females without correlation between seizures and cycle. It may be suggested that in severe epilepsy the function of neuroendocrine system is altered. Following hormonal dysfunction, the risk of seizure incidence may be increased in the second phase of menstrual cycle.

Adult↗
PubMed1979

[Fertility in the population of women with epilepsy].

Retrospective inquiry investigations of 263 women with epilepsy at the age above 15 years demonstrated that the reproductive functions in these women were twice lower than in the general population of this region. The number of unmarried was 7% above that in the population, 25% of married epileptic women had no children, and most married women controlled the birth rate resorting frequently to artificial abortions. The index of perinatal mortality of the newborns, dead fetuses and early deaths) was over three times higher than in the population: 88.2 and 25.6 respctively. The risk of spontaneous abortion was 11.3%, the risk of stillbirth 3.9%, the risk of early neonatal death 4.6%. The risk of spontaneous abortion and early neonatal death was higher in the group of women taking anticonvulsants during pregnancy.

Abortion, Spontaneous↗
PubMedDate not supplied

[Case of postpregnancy diencephalosis with manifestations of psudotumor cerebri].

The authors report a female patient with postpregnancy diencephalosis in whom in close correlation with premenstrual tension syndrome acute cerebral oedema developed repeatedly with signs of tentorial herniation. Owing to treatment with substitutive cyclopeptide hormones stimulating secondarily the failing hypophysis complete disappearance of these signs was obtained.

Adult↗
PubMedDate not supplied

[Urinary excretion of 17-hydroxycorticosteroids and 17-ketosteroids in women with epileptic seizures during the premenstrual period].

The authors determined the amounts of free and total 17-hydroxycorticosteroids (17-OHCS) and 17-ketosteroids (17-KS) in the urine of 11 women in whom epileptic seizures occurred most frequently on the 2nd and 1st day before menstruation and in 7 women with seizures showing no such correlation with the menstrual cycle. A statistically significant decrease of 17-KS was demonstrated in women with premenstrual seizures. In both groups of women the amounts of free 17-OHCS were near the lower normal range, while the amounts of total 17-OHCS were reduced and the obtained results compared with the accepted normal values showed statistically significant differences (p less than 0.01). The obtained results are, however, insufficient for assuming that these hormones play an important role in the mechanism of seizure release in premenstrual period. The authors think, on the other hand, that the statistically significant fall in 17-KS in women with premenstrual seizures may play some role among other factors in the mechanism of seizure release.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[Urinary excretion of estrogen fractions, alpha and beta pregnanediol and pregnanetriol in women with epileptic seizures during the premenstrual period].

The authors determined the amounts of oestrone, oestradiol, oestriol, alpha and beta pregnanediol, and pregnanetriol in 24-hour urine of 11 women with epileptic seizures occurring two and one day before the onset of menstruation, and in 7 women with seizures not dependent on the menstrual cycle. Determinations of these hormons were done during three successive menstrual cycles on the 2nd and 1st day before the onset of bleeding. In both groups a significant decrease was observed in the urinary levels of oestradiol and oestriol as compared with normal values. On the other hand, the amount of excreted oestrone was only slightly lowered in relation to the amount of this hormone excreted by controls. A significant decrease in the amounts of alpha pregnanediol (the difference being statistically significant at p less than 0.01 level) was observed two days before menstruation. On the other hand, pregnanetriol was decreased only in women in whom the seizures showed no temporal correlation with the stage of the menstrual cycle. The authors suggest that the observed reduction in the metabolites of progesterone in both groups was associated with an increased seizure readiness of the brain on the days preceding menstrual bleeding.

Adult↗
PubMedDate not supplied

[The course of epilepsy in girls at the age of puberty].

In 62 women the course of epilepsy was analysed at the age of puberty from 11 to 15 years of life. In 19 cases the course of the disease remained unchanged at that time, in 20 cases the seizures disappeared or became less frequent, in 20 cases the frequency of seizures increased, other types of seizures developed, or seizures present previously in childhood reappeared. The unfavourable change in the course of disease was observed more often in girls with onset of the disease at an early age, frequent seizures at the beginning of the disease, partial combined seizures, neurological and psychic abnormalities and with delayed menarche in relation to the general population.

Adolescent↗
PubMedDate not supplied

[Changes in cytohormonal cervical swabs in epileptic women].

In 16 women with epilepsy aged 18 to 38 years cytohormonal investigations were carried out during menstrual cycle. Swabs were obtained from the upper one-third of the vagina, fixed and stained by the method of Schorr. Oestrogen activity indices (PI, EI, MI) and progesterone activity indices (FI, CI) were calculated. With the exception of 2 cases in all patients the cycles were abnormal. In 1 cycle high values of oestrogen activity indices were found. In 13 patients (80%) monophasic, hypoestrogenic, cycles were observed without progesterone activity in the second phase of the cycle. The authors believe that very long anticonvulsant treatment as well as lower efficiency of the hypothalamo-hypophyseal system may reduce the level of steroid hormones produced by the ovaries which must, however, be confirmed by further clinical and experimental investigations.

Adolescent↗