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Biomedical subjects

D Rose

Publications and source records attributed to D Rose.

At least 73 records · Page 4Linked to original sources
PubMed1997

Environmental tobacco smoke exposure in the home and worksite and health effects in adults: results from the 1991 National Health Interview Survey.

OBJECTIVE: To determine the effect of environmental tobacco smoke (ETS) exposure in the home and worksite on the health of adults in the United States. DESIGN: Cross-sectional survey. SETTING: Nationally representative population. PARTICIPANTS: 43,732 adults who completed the Health Promotion and Disease Prevention supplement in the 1991 National Health Interview Survey. MAIN OUTCOME MEASURES: Rate of restricted activity, bed confinement, and work absence in the two weeks preceding the survey and self-reported health status among adults with and without exposure to ETS. RESULTS: We found that only 20.2% of never-smokers and 23.1% of former smokers reported exposure to ETS at home or work, whereas 87.2% of current smokers reported exposure to ETS. Among never-smokers, after adjusting for covariates, people who were exposed to ETS were more likely to report one or more days of restricted activity (relative risk (RR) = 1.27, 95% confidence interval (CI) = 1.10 to 1.46), one or more days of bed confinement (RR = 1.43, 95% CI = 1.19 to 1.73), and one or more days of work absence (RR = 1.33, 95% CI = 1.05 to 1.73) in the two weeks before the survey than were people without such exposure. We detected smaller trends for one or more days of restricted activity among current and former smokers (RR = 1.16, 95% CI = 0.97 to 1.40; and RR = 1.11, 95% CI = 0.82 to 1.51), one or more days of bed confinement among current smokers (RR = 1.34, 95% CI = 0.95 to 1.88), and one or more days of work absence among former smokers (RR = 1.13, 95% CI = 0.84 to 1.50) in the two weeks before the survey than among people without such exposure, although the CIs were wide and chance cannot be excluded as an explanation for these findings. Never-smokers (RR = 1.47, 95% CI = 1.34 to 1.62), former smokers (RR = 1.22, 95% CI = 1.07 to 1.39) and current smokers (RR = 1.31, 95% CI = 1.10 to 1.56) exposed to ETS were all more likely to report a less than very good health status than were people without such exposure. CONCLUSIONS: This study demonstrates that never-smoking adults exposed to ETS report more acute health effects than unexposed, never-smoking adults, and suggests similar findings in current and former smoking adults.

Adolescent↗
PubMed1997

Homophilic synaptic target recognition mediated by immunoglobulin-like cell adhesion molecule Fasciclin III.

We demonstrate that the cell adhesion molecule Fasciclin III (FAS3) mediates synaptic target recognition through homophilic interaction. FAS3 is expressed by the RP3 motoneuron and its target muscles during synaptic target recognition. The RP3 growth cone can form synapses on muscles that ectopically express FAS3. This mistargeting is dependent on FAS3 expression in the motoneurons. In addition, when the FAS3-negative aCC and SNa motoneuron growth cones ectopically express FAS3, they gain the ability to recognize FAS3-expressing muscles as alternative targets. We propose that homophilic synaptic target recognition serves as a basic mechanism of neural network formation.

Animals↗
PubMed1997

Toll, a muscle cell surface molecule, locally inhibits synaptic initiation of the RP3 motoneuron growth cone in Drosophila.

Toll, a transmembrane molecule with extracellular leucine-rich repeats, is dynamically expressed by the Drosophila embryonic musculature. Growth cones of RP3 and other motoneurons normally grow past Toll-positive muscle cells and innervate more distal muscle cells, which have down-regulated their Toll expression. In this study, we show that reciprocal genetic manipulations of Toll proteins can produce reciprocal RP3 phenotypes. In Toll null mutants, the RP3 growth cone sometimes innervates incorrect muscle cells, including those that are normally Toll-positive. In contrast, heterochronic misexpression of Toll in the musculature leads to the same growth cone reaching its correct target region but delaying synaptic initiation. We propose that Toll acts locally to inhibit synaptogenesis of specific motoneuron growth cones and that both temporal and spatial control of Toll expression is crucial for its role in development.

Animals↗
PubMed1997

Nutrient intakes of individuals from food-insufficient households in the United States.

OBJECTIVES: Understanding the nutritional consequences of food insufficiency is important for informed policy-making that addresses the problem of domestic hunger. This study estimated the extent to which individuals from food-insufficient households were likely to have low intakes of energy and 14 other nutrients. METHODS: The diets of pre-schoolers, adult women, and the elderly were analyzed with 24-hour recall data from the 1989 through 1991 Continuing Survey of Food Intake by Individuals. Logistic regression analysis was used to study the association of self-reported household food insufficiency with nutrient intakes below 50% of the recommended daily allowance. RESULTS: For adult women, food insufficiency was significantly associated with low intakes of eight nutrients, including energy, magnesium, and vitamins A, E, C, and B6. Elderly individuals in the food-insufficient group were also more likely to have low intakes of eight nutrients, including protein, calcium, and vitamins A and B6. Household food insufficiency was not significantly associated with low intakes among preschoolers. CONCLUSIONS: The results validate the use of self-reported hunger measures in nutritional surveillance and highlight nutrients of concern for food assistance and nutrition education efforts targeted at individuals from food-insufficient households.

Adult↗
PubMed1997

The ESRC review of government social classifications.

In this article we first discuss the background to the ESRC Review of Government Social Classifications and the recommendations of the Review Committee's initial report to the Office for National Statistics in 1995. Second, we discuss the work of Phase 2 of the review, including the derivation of an interim version of a proposed revised government social classification schema and the criterion and construct validation work so far undertaken using this schema. Finally, we indicate the further work required to establish the schema in its ultimate recommended form for use by ONS and others. The main purpose of the paper is to introduce users of government social classifications both to the ideas underlying the review and to the revised version of the current classifications which we shall be recommending to ONS.

Adolescent↗
PubMed1996

Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens.

1. In decerebrate kittens (n = 29), electrical activity was studied in the 3rd intercartilaginous (inspiratory), the 9th internal intercostal (expiratory) and the hypoglossally innervated muscles (geniohyoid m. and sternohyoid m.) evoked by the application of 5-HT (n = 16) or related agents (5-HT1A agonist, 8-OH-DPAT (n = 6) and 5-HT2 agonist, DOI floor of the IVth ventricle. 2. The application of a control solution (n = 2) produced no significant changes either in minute inspiratory frequency (Fi) or in the electrical activity of the muscles studied. Except for these controls, only one trial with one dose of one drug was performed in a given kitten. 3. A dose-related decrease in Fi was observed in response to 5-HT. Low doses (50-500 nmol, n1 = 8) induced a long-lasting bradypnoea; high doses (5000-10,000 nmol, n2 = 8) induced prolonged periods of apnoea. 4. The apnoeas observed in tracheotomized (n = 3) or non-tracheotomized (n2 = 8) kittens were mainly of central origin and linked to the lengthening of expiratory time. The expiratory muscle activation came on with the reinforcement of the activity of hypoglossally innervated muscles. 5. Application of agonists showed that both the 5-HT-dependent modulation of Fi and the effects of 5-HT on the activity of the muscles studied resulted predominantly from activation of 5-HT2 receptors.

Animals↗
PubMed1996

Enduring stereoscopic motion aftereffects induced by prolonged adaptation.

This study investigated the effects of prolonged adaptation on the recovery of the stereoscopic motion aftereffect (adaptation induced by moving binocular disparity information). The adapting and test stimuli were stereoscopic grating patterns created from disparity, embedded in dynamic random-dot stereograms. Motion aftereffects induced by luminance stimuli were included in the study for comparison. Adaptation duration was either 1, 2, 4, 8, 16, 32 or 64 min and the duration of the ensuing aftereffect was the variable of interest. The results showed that aftereffect duration was proportional to the square root of adaptation duration for both stereoscopic and luminance stimuli; on log-log axes, the relation between aftereffect duration and adaptation duration was a power law with the slope near 0.5 in both cases. For both kinds of stimuli, there was no sign of adaptation saturation even at the longest adaptation duration.

Adaptation, Ocular↗
PubMed1996

The effect of thrombus on the vascular endothelium of arterialized vein grafts.

BACKGROUND: It is known that vein grafts can be salvaged by clot removal, but patency rates are diminished. This study was designed to determine the effects of thrombus on vascular endothelium and the ability of the endothelium to recover normal function. METHODS: Thirty external jugular vein grafts were placed as bilateral femoral artery interposition grafts in 15 mongrel dogs and allowed to arterialize for a period of at least 12 weeks. Six control grafts were not exposed to thrombus (C-NT). Six other control grafts were exposed to thrombus for 7 days and removed, ie, allowed no in vivo recovery (C-T). The remaining 18 grafts in 9 canines were exposed to autologous thrombus for 5 days and then flow was restored. The right femoral graft was removed 7 days after thrombectomy and the left removed 30 days after thrombectomy. At the time of removal, the grafts were perfused with a balanced salt solution alone and then with arachidonic acid added to the same volume of the salt solution. Perfusates were collected at 5, 15, and 30 minutes. These perfusates were assayed for the presence of 6-keto-prosglandin F1 alpha (6-keto-PGF1(1 alpha)), a metabolite of prostacyclin (PGI2). Over the 30-day recovery period, the amounts of 6-keto-PGF1(1 alpha) produced with and without arachidonic acid added were compared to assess endothelial response. Electron micrographs of the endothelium of all vein grafts were compared to the assay findings. RESULTS: When arachidonic acid was added to the perfusion system, there was a several fold increase in the production of 6-keto-PGF1(1 alpha) over baseline in all grafts allowed recovery. Grafts (C-T) that were allowed no in vivo recovery had no response to arachidonic acid. Ratios of 6-keto-PGF1(1 alpha) production with arachidonic acid stimulation to 6-keto-PGF1(1 alpha) production without stimulation were calculated to compare endothelial function. The electron micrographs showed the vascular endothelium to be severely injured after contact with thrombus, but recovered by 7 days. CONCLUSIONS: This study suggests that the endothelium of canine vein grafts is injured by contact with thrombus for 5 days but can recover structure and function. This recovery is detectable at 7 days post-thrombectomy.

6-Ketoprostaglandin F1 alpha↗
PubMed1996

A mathematical model for analysis of pharmacologically induced changes in the kinetics of cardiac muscle.

A mathematical model of the isometric contraction of cardiac muscle is developed and utilized to characterize the inotropic and lusitropic effects of cardioactive compounds in isolated guinea pig left atria. In contrast to metrics that are based on minima and maxima of an isometric twitch and its derivative function, the entire time course of the twitch is used to quantify the kinetics of the contraction-relaxation cycle. The model relates observed tension to a time-dependent activation function that describes generation of internal force and a coupling function that determines mechanical response to the activation function. The model is structured so that it is suitable for nonlinear curve fitting to observed data. Results obtained using the model for fitting experimental data from tissues treated with different classes of cardioactive compounds agree with more qualitative results presented by other authors. Experiments using the model to fit data over an extended (90 min) time course revealed differences in the kinetic profiles of milrinone and forskolin. Computer simulations that demonstrate the effect of each model parameter on twitch kinetics are presented, and the relationships between the model and other theoretical and empirical models of cardiac muscle are discussed. The mathematical model is useful to enable a more quantitative understanding of the kinetics of cardiac muscle contraction and relaxation and identify compounds that may be selective for inotropic or lusitropic effects.

Animals↗
PubMed1996

[Iodine-125-brachytherapy of malignant choroid melanoma. II: Long-term functional outcome].

BACKGROUND: Following I-125 brachytherapy of choroidal melanoma, a good primary postoperative visual acuity results. The aim of this study is to evaluate postoperative, longterm visual acuity answering the following questions: 1) When do radiogenic complications begin to develop; 2) How long does the postoperative visual acuity remain stable; 3) Is there a difference if the treated tumor is < or = or > 3 mm off the disc and foveola respectively. PATIENTS AND METHODS: Between 12/1984-12/1989, 19 patients were treated with I-125 brachytherapy for choroidal melanoma. Height of tumor was x 5.8 mm, maximum base diameter x 11.6 mm. In 10 eyes (group A), the posterior tumor border was < or = 3 mm off the disc and foveola respectively, in 9 (group B) > 3 mm. The plaque was in situ x 7.5 days, apical radiation dose x 70 Gy, and scleral contact dose x 355 Gy. Follow-up ranged at x 6.3 years. RESULTS: Between preoperative visual acuity in group A and group B there was a statistically significant difference (p < 0.05), which remained stable 1 1/2 years postoperatively. Subsequent deterioration of visual acuity occurred later in group B than in group A, but was present after 4 1/2 years in all patients and ranged at < or = 20/400. This decrease was due to subsequent radiogenic oculopathy. CONCLUSIONS: Radiogenic complications following I-125 brachytherapy begin within the first 6 months. In group B visual acuity deteriorated later, but after 4 1/2 years, it decreased due to radiogenic oculopathy to 20/400 in all patients. Prospective longterm studies are needed to evaluate whether I-125 should be indicated for larger melanomas and Ruthenium-106 for smaller melanomas to obtain better longterm visual results.

Adult↗
PubMed1996

Perceptual learning of stereoacuity.

It has often been noted that with repeated exposure to random-dot stereograms the time required to perceived depth decreases. Further, with extensive practice, stereoacuity thresholds have been shown to decrease. For both types of learning some researchers have reported specificity of the improvements to retinal location, and have thus suggested that the learning may be localised at early levels of visual processing, such as in primary visual cortex. However, these studies have not adequately ruled out the possibility that the specificity shown may be due to the operation of selective-spatial-attention mechanisms. In the present study this possibility was examined by training observers to judge the relative depth of a pair of stereograms presented equally often in two spatial locations, but stimuli were only presented with one direction of disparity (ie crossed or uncrossed) in any one location. Results indicated that, as expected, observers' judgements improved with practice. However, this improvement transferred completely to stimuli presented with the other direction of disparity in each location. Thus, it is argued that previous findings of retinal-location-specific improvements in stereoacuity may well be due to selective-spatial-attention mechanisms, rather than to learning localised at an early level of visual processing.

Adult↗
PubMed1996

The quality of hospital discharge: a survey of discharge arrangements for the over-65s.

A three-phase study comprising semi-structured interviews with patients and/or their carers, follow-up postal questionnaires, and a postal survey of the views of professionals involved in the discharge of participating patients was conducted to assess the quality of arrangements for patients over 65 years of age, discharged from hospitals in Chester and Ellesmere Port in the United Kingdom. A large majority of patients (80%) felt they had been adequately consulted about arrangements for their discharge, but less than 2% of health and social care professionals considered all discharges satisfactory. This apparent disparity between patient and professional views may be explained by low levels of expectation among patients in this aspect of their care and their reluctance to express views which they fear may compromise future care. Continuing difficulties with interprofessional communication and liaison suggest that further attention to discharge management is required if improvements are to be effected.

Aged↗
PubMed1996

Environmental tobacco smoke exposure and health effects in children: results from the 1991 National Health Interview Survey.

OBJECTIVE: To determine the effect of environmental tobacco smoke exposure on the health of children in the United States. DESIGN AND SETTING: Cross-sectional study of children who participated in the 1991 National Health Interview Survey. PARTICIPANTS: 17448 children residing in the United States. MAIN OUTCOME MEASURES: Rates of respiratory illnesses and all illnesses, and the morbidity due to these illnesses, in children exposed to environmental tobacco smoke in the home daily compared with those in children not exposed in the home. Our analyses controlled for age, socioeconomic status, race, family size, sex, season, and region of the country. RESULTS: Children who were exposed to environmental tobacco smoke had a higher incidence of acute respiratory illnesses (relative risk (RR) = 1.10, 95% confidence interval (CI) 0.95 to 1.26) and all chronic respiratory diseases (RR = 1.28, 95% CI 0.99 to 1.65) than children who were not exposed, although both CIs included unity, and chance cannot be ruled out as being responsible for these findings. Children who were exposed to environmental tobacco smoke had, on average, 1.87 more days of restricted activity (95% CI 0.20 to 3.54), 1.06 more days of bed confinement (95% CI 0.20 to 1.92), and 1.45 more days of school absence (95% CI 0.40 to 2.50) per year than children who were not exposed. CONCLUSIONS: Environmental tobacco smoke exposure in the home, which is completely preventable, is an important predictor of increased morbidity in children.

Adolescent↗
PubMed1996

Radiographic features of staphylococcal pneumonia in adults and children.

BACKGROUND: Clinical and laboratory features do not accurately correlate with the cause of community acquired pneumonia. A study was performed to examine whether the radiographic features of staphylococcal pneumonia are sufficiently distinct to aid early diagnosis. METHODS: The chest radiographs of 34 patients (including eight children) with proven staphylococcal pneumonia were reviewed by two experienced observers using methods described previously. Features on presentation and follow up were noted. RESULTS: The most striking features were the presence of multilobar consolidation on presentation, cavitation, pneumatocoeles and spontaneous pneumothorax, together with a tendency to radiographic deterioration after admission in both adults and children. Some of these features are much less common with other causes of community acquired pneumonia. However, most of the cases did not have these classic features. CONCLUSIONS: The presence of certain radiographic features, including multilobar shadowing, cavitation, pneumatocoeles, and spontaneous pneumothorax, are seen with staphylococcal pneumonia in adults and children, but their absence does not exclude the diagnosis.

Adult↗
PubMed1996

Novel mouse embryonic renal marker gene products differentially expressed during kidney development.

Investigators approaching the problem of renal organogenesis have been hampered by a paucity of suitable molecular markers that specify distinct developmental phenotypes. To identify such markers, differential display-polymerase chain reaction (DD-PCR) was used to survey the temporal pattern of gene expression in mouse kidney at 11.5, 13.5, 15.5, and 17.5 days after conception and in the adult kidney. Twenty-two differentially expressed amplification products were identified, isolated, and sequenced. Seventeen clones showed no significant similarity with previously reported nucleotide sequences: two were similar to two housekeeping gene products, and three were similar to human or rat expressed sequence tags. To confirm the differential expression patterns observed by DD-PCR, semiquantitative reverse transcription-PCR was performed using sequence-specific oligonucleotide primers. Nineteen of 22 clones were differentially expressed during kidney development [mouse embryonic renal marker (MERM) sequences 1-19]. The value of MERMs as developmental markers was further assessed in mouse metanephric organ culture, where the pattern of MERM transcript expression mimicked that observed in vivo. Therefore, the DD-PCR method permitted development of a panel of marker sequences that can be used to characterize renal developmental processes and that may allow the identification of novel, functionally relevant gene products.

Animals↗
PubMed1996

[Exploratory study of amitriptyline resistance in depressed patients: results of WHO French collaborating center on depressions resistant to treatments].

A multicountry, multicentre double-blind study in a group of depressives, coordinated by the Mental Health Division of the World Health Association (WHO) has been done. The goal of the study is to determine whether the therapeutic effects of amitriptyline can be enhanced and potentiated by combining it with an antioxydant (gingko biloba). An exploratory study has preceded the main study which had the objective to estimate the proportion of non-response patient to amitriptyline. We report the results concerning the French center. 23 inpatients meet the ICD-10 criteria for depression (F32 and F33) and were treated during 6 weeks by amitriptyline with the initial daily dose of 50 mg until the maximum dose of 200 mg. The proportion of non-responsive patient to amitriptyline was 34.78 (95% confidence interval : 15.32 to 54.24%), all clinically deteriorated.

Adult↗