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Biomedical subjects

D Rothwell

Publications and source records attributed to D Rothwell.

13 recordsLinked to original sources
PubMed1984

A miniature infuser for the pulsatile administration of LHRH.

This paper describes a compact, battery-powered infuser that is light, unobtrusive and simple to operate. A novel direct-drive method is used to deliver intermittent boluses of hormone at predetermined time intervals via a special prefilled syringe. Normal pregnancy rates were achieved in anovulatory women when infused with luteinising hormone releasing hormone (LHRH).

Biomedical Engineering↗
PubMed1983

A new miniature, open-loop, extracorporeal insulin infusion pump.

This extracorporeal insulin infuser has been designed to be compact, simple to operate, and suitable either for clinical investigations of insulin-dependent diabetes mellitus or for long term treatment of the condition. A syringe driver of unconventional design is used, and the syringe will be available prefilled with insulin, specially formulated at standard strength for long term infusion. The device is electronically controlled to give variable rates of basal infusion, preset by switch and supplemented by bolus infusions demanded by pushbutton prior to meals. Sufficient insulin is carried in the syringe to meet the needs of most diabetics for at least a week without refilling, and the battery life is commensurately long. Signalling of the mealtime dose regime, and of alarm and failure conditions is by audible means. Insulin will most commonly be delivered subcutaneously, though other routes are possible.

Biomedical Engineering↗
PubMed1977

A miniature syringe pump for continuous administration of drugs and hormones: The Mill Hill infuser.

A miniature syringe pump has been developed for intravenous or subcutaneous infusion of the many drugs and hormones which produce better therapeutic responses when continuously delivered at a controlled rate than by repeated separate injections. The infuser uses disposable plastic syringes and is designed for precise tamper-proof delivery of 2 ml/24 h or 2 ml/8 h with quartz-crystal control, unaffected bt the dose-rate can be precisely determined by prescribing solutions of appropriate strength.

Hormones↗
PubMed1977

Chronic lymphocytic leukemia--well-differentiated lymphocytic lymphoma with monoclonal IgA:IgA production by circulating lymphocytes.

A patient is described in whom morphologic features of well-differentiated lymphocytic lymphoma (WDL) or chronic lymphocytic leukemia (CLL) and immunologic features of multiple myeloma were present. Studies of isolated peripheral blood lymphocytes demonstrated de novo synthesis of IgA K, the same paraprotein that was identified in the serum. Predominant IgA synthesis by peripheral lymphocytes has not been previously shown in either WDL or CLL.

Humans↗
PubMedDate not supplied

Meeting the problems of first-generation insulin infusion pumps: clinical trial of a new miniature infuser.

We designed and constructed a new miniature, open-loop insulin infusion pump specifically to overcome the problems of many first generation insulin infusers. Special features are small size, adjustable volumetric basal infusion rate, rapid electronically mediated prandial insulin boosts, facility for doubling and halving the basal infusion rate and/or prandial delivery, and alarms for low battery state, motor over-run, stoppage, and control circuit malfunction. The infuser takes a specially designed syringe prefilled with short-acting insulin, sufficient in most diabetic patients for at least 7 days treatment with 100 U/ml insulin. To test clinical efficacy nine insulin-dependent diabetic patients received continuous subcutaneous insulin infusion (CSII) with the new infuser for periods up to 6 mo. Four patients previously CSII-treated with a first-generation pump and five who were new to CSII achieved and maintained the expected degree of near-normoglycemia. There were no pump breakdowns and a questionnaire completed by patients during the study confirmed ease and simplicity of operation and an appreciation of the advantages of the new pump compared with one widely used first-generation infuser.

Adult↗