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Biomedical subjects

D Rozenman

Publications and source records attributed to D Rozenman.

At least 19 recordsLinked to original sources
PubMed2006

Minocycline-induced cutaneous hyperpigmentation: confocal laser scanning microscope analysis.

BACKGROUND: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. OBJECTIVE: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. METHODS: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). RESULTS: A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. CONCLUSION: Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.

Adolescent↗
PubMed2006

Epidemiological and clinical manifestations of patients hospitalized with brown recluse spider bite.

BACKGROUND: Necrotic arachnidism represents a common health problem and standard treatments are usually safe and effective. OBJECTIVE: The aim of this study was to review documented Loxosceles species spider envenomations and identify the natural history of affected patients. METHODS: A retrospective single-centre study included 52 patients with necrotic arachnidism hospitalized in the dermatology department between 1997 and 2004. We examined the relationship between the epidemiological, clinical and laboratory parameters and degree of lesion severity, length of hospitalization and time to complete healing. RESULTS: The bites occurred predominantly in rural areas, 67% between April and August. Only 35% of the patients sought medical care within 24 h post bite. Most bites were of the extremities (67%). Time to complete healing ranged from 14 days to more than 8 weeks (mean, 4.8 weeks). A marked relationship was found between age, comorbidities, lesion severity and time to complete healing (P < 0.01). Duration of hospitalization was significantly longer in patients with severe thigh lesions (P < 0.02). CONCLUSIONS: Loxosceles species spider bites frequently induce necrotic, slowly healing ulcers on the fatty areas of the body. Early, appropriate systemic therapy may provide clinical benefit.

Adolescent↗
PubMed2005

Cat scratch disease encephalopathy in an immunocompetent patient.

Cat scratch disease (CSD) is typically a self-limited regional lymphadenopathy in children and young adults that is caused by Bartonella henselae. The majority of CSD cases resolve spontaneously; however, many systemic complications have been described. We report an unusual case of CSD presenting as an epitrochlear arm mass and complicated by encephalopathy. Identification of B. henselae DNA in the affected lymph node and cerebrospinal fluid confirmed the diagnosis of CSD. Systemic antibiotic therapy was administered and the patient improved without any neurological deficit.

Journal Article↗
PubMed1994

[Herpes zoster treated with acyclovir].

During the past 5 years, 99 patients with herpes zoster were hospitalized and followed. Age, sex, localization of rash, complications, duration of hospitalization and treatment were analyzed. Most patients were in their 6th and 7th decades. Cranial nerve involvement was frequent (35%). A generalized rash was more common in those with immunodeficiency. Acyclovir (Zovirax) inhibited to some extent the spreading of the rash and reduced the frequency of herpetic neuralgia. Our findings are in accord with those in the literature.

Acyclovir↗
PubMed1989

Skin-isolated, community-acquired Staphylococcus aureus: in vitro resistance to methicillin and erythromycin.

During a 10-month period, skin culture specimens were taken from 1680 healthy outpatients with a variety of community-acquired skin infections. Staphylococcus aureus was found in 1035 (61.6%) of these patients. In vitro resistance to methicillin and erythromycin was 1.0% and 42.9%, respectively. Resistance rates to erythromycin in patients with furunculosis and impetigo were 51.5% and 26.2%, respectively (p less than 0.001). The emergence of erythromycin-resistant strains may be the result of widespread use of this drug in our geographic area. There is also the possibility that certain bacteriologic features associated with erythromycin resistance may foster the development of furunculosis.

Adolescent↗
PubMed1989

Isolated necrosis of the tubal fimbriae in a prepubertal girl.

A report of haemorrhagic necrosis of the tubal fimbriae in a prepubertal girl is presented. The presumptive aetiology for this is the isolated torsion of the fimbrial end which, to the best of our knowledge, has not been previously described. A high index of suspicion of torsion and early intervention is emphasised. Laparoscopy should usually precede laparotomy in doubtful cases but during laparotomy as little as possible should be done in order to retain future fertility.

Abdomen, Acute↗
PubMed1989

Tamoxifen treatment in women with failure of clomiphene citrate therapy.

Fourteen pregnancies were achieved with tamoxifen therapy in 12 women who failed to conceive with clomiphene citrate. There were no side-effects and fewer treatment cycles were required than with clomiphene citrate treatment. Ovulation and cervical score with tamoxifen therapy were significantly higher (p less than 0.005).

Adult↗
PubMed1984

Onchocerciasis in Israel.

A 15-year-old boy with onchocerciasis had severe generalized pruritus of five months' duration. He had been born and raised in Ethiopia and had emigrated to Israel one year earlier. A biopsy specimen of an area of depigmentation on the right thigh disclosed microfilaria of Onchocerca volvulus in the dermis. The discovery of an unusual disease in a nonendemic area is an example of the increased complexity of differential diagnosis resulting from the ease of travel from one geographic region to another.

Adolescent↗
PubMed1984

Prevention of reformation of pelvic adhesions by "Barrier" methods.

Twenty-five female rabbits received symmetrical injuries on both uterine horns. Ten days later the animals were re-operated and the adhesions were lysed and covered on one of the uterine horns with silicone in ten animals (Group A) and with Surgical in ten other animals (Group B). The contralateral uterine horns served as internal controls and five animals in whom no barrier was used served as an external control (Group C). The silicone was removed in a third operation ten days later. A scoring method was used for the quantitation of the adhesions. The reformation of adhesions on the treated side was reduced in Group A (mean score 1.4 +/- 1.5) and increased in Group B (mean score 3.8 +/- 0.43) in comparison with Group C (mean score 2.5 +/- 1.03) (P less than 0.02).

Animals↗
PubMed1983

Effects of short-term treatment with gonadotropin-releasing hormone (GnRH) or ethinyl estradiol on the pituitary responsiveness to GnRH.

In 4 patients with hypothalamic amenorrhea, the pituitary responsiveness to an intravenous challenge of 20 micrograms synthetic gonadotropin-releasing hormone (GnRH) was evaluated before and following a 3-days treatment course with GnRH (100 micrograms/per day i.m.) or ethinyl estradiol, (100 micrograms/day orally). The amenorrheic patients all had normal or reduced levels of serum gonadotropins, no evidence of galactorrhea and no other endocrine abnormality. Following GnRH treatment basal luteinizing hormone levels as well as the luteinizing hormone and follicle-stimulating hormone responses to GnRH were markedly reduced when compared with responses to GnRH before the treatment. Responses to GnRH were significantly augmented after treatment with estrogens. In patients with previous treatment with GnRH the augmented estrogen-induced LH response to GnRH was abolished. These preliminary results support the pathophysiological concept that in amenorrheic patients with hypothalamic dysfunction long-term administration of GnRH does not result in an improvement but rather in a deterioration of pituitary gonadotropic function.

Adult↗