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Biomedical subjects

D Rubenstein

Publications and source records attributed to D Rubenstein.

At least 37 records · Page 2Linked to original sources
PubMed1976

Gaseous exchange and acid-base balance in premature lambs during liquid ventilation since birth.

Nine distressed premature lambs were studied before, during, and after ventilation with fluorocarbon liquid (FC-80). It was found that premature lambs, delivered by cesarean section, could be adequately ventilated with oxygenated liquid for period up to 3 hr. Using fluarocarbon liquid in conjunction with the described liquid breathing system, it was possible to maintain remarkably good pulmonary gas exchange and acid-base balance during normothermic conditions. In addition, peak intratracheal pressures measured during recovery from liquid ventilation were significanly reduced (P is less than 0.001) as compared with preliquid ventilation values. This improvement in lung function is in direct contrast to the deterioration in that of the adult animal following liquid ventilation as reported previously.

Acid-Base Equilibrium↗
PubMed1972

A virus from epidemic vomiting disease.

An illness consisting of vomiting, fever, and mild diarrhoea after a short incubation period was observed in a boarding school and reproduced in volunteers who received filtered extracts of faeces from a typical case. The main discriminatory diagnostic feature of the illness in volunteers was vomiting. The faeces contained no pathogenic bacteria nor any virus that could be detected in tissue cultures and there was no evidence that an infective agent could be grown in organ cultures of human intestine. The agent was shown to be ether stable and passed a 50-nm filter. Laboratory studies on another agent of uncertain significance and obtained in other epidemics are briefly described.

Adolescent↗
PubMed1971

New antigen-antibody system in Australia-antigen-positive hepatitis.

After detergent treatment the 42 nm. Dane particles from the sera of patients with serum hepatitis separate into an outer coat of Australia antigen (Au-Ag) and an inner spherical 27 nm. diameter component resembling a rhinovirus. Antibody in post-hepatitic serum reacted with the inner component (but not with the outer) to yield aggregates resembling those seen in the liver of patients with serum hepatitis. Antibody to Au-Ag was not detected, before or after the attack of hepatitis. It is suggested that, in an attack of serum hepatitis, Au-Ag antibody develops but is subsequently cleared; antibody against the inner Dane component, however, persists.

Hepatitis B↗
PubMed1970

Vaccination against Hong Kong influenza in Britain, 1968-9. A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines.

Studies of the effect of Hong Kong (HK) influenza vaccine were made in adults and children in Great Britain during 1968 and 1969. The vaccines were administered intramuscularly and also by intranasal spray. The serum antibody response was studied in 284 subjects. Most developed rising titres to vaccine given intramuscularly and few to vaccine given intranasally. Deoxycholate-split vaccine was as potent as conventional whole virus vaccine. Antibody titres were maintained for months. Over 4000 subjects in factories, offices and schools were observed during the epidemic. The incidence of disease was not significantly reduced by either form of vaccination. A survey was made of epidemics in boarding schools in which some of the pupils had been vaccinated, in six with commercial polyvalent vaccine and in five with HK; there was a lower incidence of influenza in two schools vaccinated 2 or 4 weeks earlier with HK vaccine.

Adult↗