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Biomedical subjects

D Rutt

Publications and source records attributed to D Rutt.

5 recordsLinked to original sources
PubMed1986

Effect of internal carotid artery occlusion on middle cerebral artery blood flow at rest and in response to hypercapnia.

In patients with symptomatic cerebrovascular disease the rise in middle cerebral artery (MCA) blood-flow velocity in response to hypercapnia, recorded with a pulsed transcranial doppler velocimeter, was significantly less in MCAs above a totally occluded carotid artery than in MCAs above a patent carotid. These findings support the existence of compensatory cerebral vasodilatation above a carotid occlusion and suggest that transient ischaemic attacks in patients with carotid occlusion may be flow-related rather than embolic phenomena. These patients may therefore benefit from extracranial-intracranial surgical revascularisation. The method presented is non-invasive and therefore ideally suited for use as a screening test or in follow-up studies.

Adult↗
PubMed1983

Lymphatic obstruction and lymph node changes--a study of the rabbit popliteal node.

Dense cortical lymph node fibrosis is associated with primary lymphedema and proximal obstructive hypoplasia. The fibrosis is not related to the duration of disease nor to episodes of clinical cellulitis. This suggests that the disease may start in the nodes but the effects of obstruction in the adjacent lymph vessel must be elucidated before the assumption is made. The popliteal nodes of 49 rabbits were studied following the ligation of either afferent or efferent lymphatics, and compared with nodes following a sham operation. The efficacy and late effects of ligation were assessed in half the rabbits by cinelymphangiography. In the rest Patent Blue Violet and not Lipoodol was used to minimize any spurious effect on node histology. The rabbits were sacrificed between 6-84 days. Node area was measured on serial x-rays and node volume after removal of the node. Afferent ligation resulted in a significant and permanent decrease in size (p less than 0.005) and lymphocytic congestion; efferent ligation resulted in an increase in size (p less than 0.02) and large lymph spaces. The dense node fibrosis of primary lymphedema was not seen.

Animals↗
PubMedDate not supplied

Transcranial Doppler measurement of middle cerebral artery blood flow velocity: a validation study.

Measurement of intracranial arterial blood flow velocity is a new technique with potentially a number of very useful applications. This study validates the technique by comparing it to cerebral blood flow (CBF) measured using intravenous Xenon133 and extracranial clearance recording. We have measured the middle cerebral artery (MCA) blood flow velocity in 17 symptomatic patients with the EME TC 264 transcranial Doppler velocimeter and compared these measurements to the ipsilateral hemispheric cerebral blood flow measured with an intravenous Xenon133 technique (Novo Cerebrograph 10A). Measurements were made at rest and during hypercapnia. The absolute measurement of MCA velocity and hemispheric CBF showed a poor correlation (r = 0.424, p less than 0.01) due to wide between-patient variations at rest but the blood flow response to hypercapnia, expressed as a reactivity index, showed a good correlation (r = 0.849, p less than 0.001). Thus changes in MCA velocity reliably correlate with changes in cerebral blood flow but the absolute velocity cannot be used as an indicator of CBF.

Adult↗