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Biomedical subjects

D S Borgaonkar

Publications and source records attributed to D S Borgaonkar.

At least 55 records · Page 3Linked to original sources
PubMed1977

Sister chromatid exchanges in balanced translocation carriers and in patients with unbalanced karyotypes.

Sister chromatid exchanges (SCEs) were studied in peripheral human leukocytes from 16 patients with balanced translocations or with unbalanced karyotypes, and from 4 controls. No difference was seen between these two groups of people in the mean number of SCEs per cell, or in the total number of SCEs observed for each pair of autosomes involved in the translocations studied. With this last number no difference from the expected number of SCEs, if one supposes that SCEs follow a random distribution, was seen.

Chromatids↗
PubMed1977

Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

A number of individuals with aberrant Y chromosomes have been tested for the presence of Y-chromosome-specific reiterated DNA. These studies locate Y-chromosome-specific reiterated sequences on the long arm of the Y chromosome. Correlation with phenotype and other known Y chromosome markers establish that the Y-chromosome-specific reiterated DNA discussed here has no evident role in male determination.

Base Sequence↗
PubMed1977

Pituitary function in adult males receiving medroxyprogesterone acetate.

The pituitary, adrenal, and gonadal functions of nine males (six XY, two XYY, and one XY/XYY) were studied after at least 6 months of medroxyprogesterone acetate (MPA) therapy for antisocial or sex-offending behavior. Five were studied both before and during therapy, four only during therapy. MPA was effective in decreasing serum gonadotropin and plasma testosterone concentrations. MPA caused no change in the 24-hour rhythm or total integrated concentration of growth hormone. The plasma cortisol circadian rhythm was suppressed but not obliterated by MPA therapy. Although a significant decrease (P less than 0.001) in 24-hour integrated concentrations of plasma cortisol was also found, the rise in the plasma cortisol level after insulin-induced hypoglycemia was unchanged.

Adrenal Cortex↗
PubMed1976

Structural aberrations of the long arm of chromosome no. 22. Report fo a family with translocation t(11;22) (q25;q11).

A chromosomal translocation t(11;22) (q25q11) is described in a family. Four members, in two generations, had the same translocation but showed phenotypic variation. Case reports of chromosome aberrations involving the long arm of chromosome 22 associated with and without chronic myeloid leukemia (CML) are reviewed. It appears that the distal segment of the long arm or chromosome 22 is either translocated or deleted, resulting in congenital anomalies, presumably due to chromosome imbalance. In other instances, a specific breakpoint on 22q results in the origin of Philadelphia chromosome (Ph1) associated with CML.

Abnormalities, Multiple↗
PubMed1976

Effect of vincristine on sister chromatid exchanges of normal human lymphocytes.

In vitro analysis of the mitosis from 3-day lymphocyte cultures from two normal males and two normal females treated with bromodeoxyuridine and stained with acridine orange after addition of vincristine during different times demonstrated that vincristine inhibits the progression of the second division. When the second division progressed, the number of sister chromatid exchanges was significantly decreased. Vincristine could act by inhibiting the copying of DNA. A dosage effect is demonstrated when vincristine is added to the cultures during the first 24 hr.

Cells, Cultured↗
PubMed1975

Treatment of cryptorchidism. Long-term prospective study.

We have presented preliminary findings on a long-term prospective study designed to (1) assess timing of orchiopexy, (2) eliminate unnecessary abdominal exploratory surgery, and (3) determine efficacy of orchiopexy on subsequent fertility and on malignant degeneration. Some suggestions for the management of this common congenital defect can be provided, but long-term results are lacking. A significant drop-out rate from this prospective study is expected with time; therefore, large patient numbers are needed to draw any valid conclusions at the time of postpubertal reassessment.

Chorionic Gonadotropin↗
PubMed1975

XYY syndrome, stigmatization, social class, and aggression: study of 15 cases.

This is a paper about the relationship of stigmatization to social class in XYY individuals, and of this relationship to manifestations of agressive behavior. The sample comprised 15 men and youths with the XYY syndrome; 8 were identified in a survey of institutions for males with behavior disorders and 7 were privately referred. All had been stigmatized by physique and appearance and/or behavior. The most frequent stigmatizing features were excessive height for age, excessive impulsiveness in behavior, and excessive temper tantrums in childhood; these were present in all cases. Antisocial or law-breaking behavior was present in 13 cases. Stigmatization did not correlate with socioeconomic class, rated according to the Shevky and Bell scale as modified to suit the study. However, the consequences of stigmatization were class related in that the lower the class, the greater the chance that the XYY individual would spend time in the penal as well as the medical system of society.

Adolescent↗