PubMed HealthSearch

Biomedical subjects

D S Brettle

Publications and source records attributed to D S Brettle.

5 recordsLinked to original sources

Technical note: dual compression mammography using computed radiography.

On mammography most malignant growths may be seen as a tethered mass or architectural distortion. Benign lesions such as cysts and fibroadenomas have no focal tethering and are usually well circumscribed. Computed radiography (CR) is a direct digital system which may be used for mammography. One of the main advantages of CR is its wide exposure latitude allowing images to be acquired at lower exposures than required for film-screen systems. A technique was developed, utilizing the exposure latitude of CR, to acquire two mammograms of the same breast at two slightly different compressions, but using approximately the same exposure as a single film-screen mammogram. These images were then "animated" on a computer allowing the fibrous septa movement to be visualized. The movement of the fibrous septa in the presence of an abnormality was used to help confirm whether a lesion was benign or malignant. This technique may have clinical application in classifying architectural distortions and masses which are ultrasonically benign but later found to be malignant. Microcalcifications cannot be used as a diagnostic indicator with this technique because of the increased noise associated with the lower exposures. The increased noise did not affect the visualization of masses.

Breast Neoplasms

A clinical comparison between conventional and digital mammography utilizing computed radiography.

Previous work utilizing a specially designed mammographic test object has indicated that the image quality of computed radiography (CR) approaches that of a conventional film-screen technique of equivalent radiographic speed. In an attempt to correlate these results with the clinical situation a subjective rating study of the primary physical parameters of noise, sharpness, and contrast has been conducted. Using a randomized viewing sequence two radiologists experienced in mammography were asked to score these parameters utilizing a 5 point scale. A total of 138 images was used, 62% containing no abnormalities and 38% containing either microcalcifications, masses or both. Additionally, the observers scored their confidence of correct classification, and these results were then used to construct receiver operating characteristic (ROC) curves. The subjective rating of the physical parameters results produced similar results to those obtained using the test object, with CR images providing greater contrast than film. The resolution of CR, however, was lower than for film. Overall the noise levels were similar for both modalities, but the digital images occasionally contained high levels of dust artefacts. In one case these artefacts were mistaken for a cluster of microcalcifications. The test object results and the parameter rating results indicate that CR approaches the performance of film-screen images. Statistically the ROC curves produced indicate CR images to be comparable to the film-screen combination. This may be because the increased contrast compensates for resolution limitations and these findings correlate with our clinical experience.

Breast Diseases

Physical evaluation of computed radiography as a mammographic X-ray imaging system.

The physical imaging properties of a computed radiography (CR) system operating under mammographic exposure conditions have been measured. These measurements include modulation transfer function (MTF), sensitometric response and noise power spectrum (NPS). These figures were used to derive signal-to-noise ratio (SNR) descriptors of the system performance. The same measures were derived for a mammographic film-screen system. The SNR properties of the CR system indicate superior low frequency performance over a wider dynamic range than the film-screen system. The spatial frequency dependent SNR properties of the CR system are, however, limited. The results of a psychophysical test support the results obtained from physical measurements. These results indicate that despite its limited sharpness, details of dimensions relevant to diagnosis in mammography (circular details 0.25 mm diameter to represent microcalcifications and 3 mm diameter to represent small masses) are reproduced using CR with SNRs which are at least comparable with those of a mammographic film-screen system.

Breast Diseases

A preliminary investigation of the imaging performance of photostimulable phosphor computed radiography using a new design of mammographic quality control test object.

Leeds Test Object TOR[MAM] has been designed to supplement the current FAXIL mammography test object TOR[MAX]. It contains a range of details that have a more natural radiographic appearance and has been designed as a test that more closely approximates the image quality achieved in clinical mammography. Physical aspects of the design and implementation of TOR[MAM] are presented. The TOR[MAM] has been used in a preliminary physical evaluation of the comparative image qualities produced by conventional (screen-film) and photostimulable phosphor computed mammography and the results are discussed. TOR[MAX] results are also presented. The influence of digital image processing (enhancement) on the image quality of computed mammograms is also considered. The results presented indicate the sensitivity of TOR[MAM].

Female