A multicentre health promotion programme for coronary heart disease.
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Biomedical subjects
Publications and source records attributed to D S Chatterjee.
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This double-blind case-control study on hand-arm vibration syndrome was sponsored by the Society of Occupation Medicine Golden Jubilee Travelling Scholarship Committee in 1987. It involved collaborative work between the author and the Department of Clinical Neurosciences, Institute of Occupational Health, Helsinki, Finland. The procedure consisted of administration of a questionnaire, clinical examination of subjects in the study group and depth-sense esthesiometry for all subjects including the controls. Of 34 subjects admitted to the study, 14 out of 15 patients were positively diagnosed as suffering from the syndrome and one out of 19 in the control group had a false positive result. The study showed that the new esthesiometer, although not totally objective, could be regarded as an effective tool for the diagnosis of hand-arm vibration syndrome in clinical and field studies.
A prospective longitudinal study was carried out to investigate the occurrence of upper limb disorders in an electromechanical plant between 1980 and 1988. It included clinical and epidemiological studies, measurement of vibration produced by the power tools used, ergonomic assessment of the works and time and motion studies. Simultaneously during the same period remedial actions were taken through multidisciplinary interventions when the specific causal factors were known. The study shows the clinical entities of the disorder, identifies the risk factors and evaluates the results of the interventions. It assists in establishing a cause and effect relationship for the condition and demonstrates the way a preventive strategy could be developed.
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The structure and functions of a depth-sense esthesiometer have been described. Unlike the prototype designed by Renfrew, the new instrument is so fabricated that the speed and the directions of its movements, and the pressure applied by the finger, can be constantly controlled. In addition, it provides an automatic measurement of depth-sense thresholds with greater accuracy. Thirty-three normal subjects and nine patients were examined with both instruments. With the new esthesiometer all normal hands, as expected, showed normal results, but, with the Renfrew instrument, 12 of these 66 hands (18%) showed abnormal results. Similarly, on examination of the hands of the nine patients, the new instrument showed equally improved reliability.
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Electrophysiological observations made in the hands of a group of 16 rock-drillers were compared with 15 controls. Motor and sensory conduction velocities in the median and ulnar nerves together with the latency, duration, and amplitude of the evoked action potentials were measured. The differences between the groups were statistically significant mainly in latency, duration, and amplitude, especially of the sensory action potentials. Measurement of the conduction velocities, in general, proved to be less sensitive, and the only significant change observed was in the sensory conduction velocity in the median nerve when the first digit in the right hand was stimulated. The most interesting result was evidence of an increased prevalence of possible carpal tunnel syndrome in the exposed (44% compared with 7% in the control group). A similar set of data, but exclusively sensory and not standardised for age and sex, was obtained from 25 university students for comparison with the assigned groups. The results showed that apart from sensory duration the control group had values that were closest to the students while the vibration group had values furthest away.
A combined epidemiological and clinical study of vibration-induced white finger (VWF) was carried out involving 115 men in four fluorspar mines. The overall prevalence of VWF was found to be 50% among 42 vibration-exposed subjects, while that of constitutional white finger (CWF) was 5-6% in all men studied. The VWF latent interval was 1-19 years with a mean of 5-6 years. An association was observed between the exposure time and VWF stages which included 18 men in Stage 0, three in the intermediate Stage of 0T/0N, five in Stage 2 and 16 in Stage 3; no men were seen at Stage 1. Among those with VWF in Stage 3, the index, middle and ring fingers were affected in both hands and the little fingers and thumbs were last to be involved. Clinically, on general examination, apart from vibration-induced white finger, the men in the 'vibration' group were not as healthy as those in the 'control' group. The circumference of the index fingers was not significantly different for the different groups. Neurological tests showed that the ridge test and, to a lesser extent, the two-point discrimination and the light touch tests, could be regarded as useful for the diagnosis of VWF.
Twenty-eight patients with partial thickness skin loss of the limbs, mainly due to burns, were treated on an out-patient basis in an occupational health centre. Thirteen patients were treated with porcine skin graft and the other 15 by the conventional method with paraffin gauze. The results showed that the median healing time was 13 days in the porcine skin graft group and 28 days in the control group. Other than healing time, the effects of porcine xenograft in reducing pain, infection and sickenss absence were far greater than those with conventional treatment. From a comparison of total dressing costs, it was estimated that for lesions of comparable size the cost of treatment with porcine xenograft was approximately one-third of that using paraffin gauze.
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A double-blind, controlled clinical study with benzydamine hydrochloride 3% cream was conducted in an Occupational Health Centre on fifty patients with soft tissue injuries (two mild, ten moderate and thirteen severe cases in the placebo group and one mild, thirteen moderate and twelve severe cases in the active group). The trial demonstrated the significant therapeutic superiority of 3% benzydamine cream over inactive placebo in all six qualitative parameters for traumatic inflammatory changes at the end of a six-day assessment and a marked improvement of symptoms event two days after the onset of therapy. In addition, tbe incidental use of ultrasound therapy together with the standard treatment revealed the value of the active drug as an effective couplant. Neither group suffered any side-effects. Although the size of population studied was small, it was apparent that active treatment with benzydamine was a distinct aid to healing of soft tissue injuries and this should be confirmed with further large-scale clinical trials.