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Biomedical subjects

D S Choudhury

Publications and source records attributed to D S Choudhury.

At least 19 recordsLinked to original sources
PubMed1997

Role of macrophages in experimental malaria: IV--Bioassay of silica in immunity against Plasmodium berghei infection.

Silica treated mice when challenged with Plasmodium berghei showed increase in duration of prepatent(PP) and survival period (SP) and median survival day(MSD) as compared with controls. Daily parasite density curve during the course of infection was similar to control. Response to the parasite challenge, however, was dependent on the dose of silica. No increase in SP at 0.7 mg and in PP at 35 mg (cumulative doses) dose was observed. A dose upto 5 mg per mouse before challenge resulted in protection of the animal. No mortality was recorded in mice which received silica alone (35 mg; 5 mg/day x 7 days). Death due to lethal P.berghei infection could be delayed or prevented by altering/reducing the functional activities of macrophages during the course of infection.

Animals↗
PubMed1993

Role of An. culicifacies and An. stephensi in malaria transmission in urban Delhi.

Studies on adult densities, vector incrimination and breeding habitats of An. culicifacies and An. stephensi were carried out during June 1984 to May 1986 in three different ecological areas of urban Delhi. Both An. culicifacies and An. stephensi prevailed throughout the year in peri-urban areas with higher densities during the post-monsoon months. In south and northwest areas, low densities of these vector species were recorded. An. culicifacies was found naturally infected with sporozoites in peri-urban and south areas, whereas An. stephensi showed gland infection in south areas only. Out of 827 blood smears collected, 302 were positive for malaria parasites. Of the positives, P. vivax formed 48.3% and P. falciparum 51.7%. Peri-urban areas showed a higher number of malaria cases than south and northwest areas.

Animals↗
PubMed1989

Drug resistant P. falciparum in Madras (Tamil Nadu) and district Jabalpur (Madhya Pradesh).

WHO micro in vitro tests for chloroquine resistance in P. falciparum were carried out during November, 1987 in Madras city, Tamil Nadu and in Kundam PHC of Jabalpur district, Madhya Pradesh. Out of 6 samples tested from Madras city, 5 showed resistance to chloroquine. Likewise, out of 14 samples tested in Jabalpur, 12 (85.7%) showed resistance to chloroquine. All the 20 samples showed normal susceptibility to mefloquine.

Adolescent↗
PubMed1973

Poliomyelitis vaccination of infants: preimmunization status and seroconversion.

A study was carried out in Delhi on the preimmunization status of infants aged 2-6 months with regard to poliomyelitis and on seroconversion after the administration of oral poliomyelitis vaccine. It was found that 30.3% of the 204 infants included in the study excreted enteroviruses, 58% of which were found to be polioviruses. Of 197 sera examined for neutralizing antibodies against different types of poliovirus, 73% were found to be triple negative and only 4.0% triple positive. Three doses of oral poliomyelitis vaccine were administered at intervals of 1 month. It was found that 71.8% of the vaccinated infants excreted cytopathogenic agents in the 7 days following the first dose; 80.4% of these agents were found to be polioviruses. Seroconversion was studied in 71 infants, and good antibody responses to all three types of poliovirus were observed.

Antibodies, Viral↗