Biomedical subjects

D S Hendawy

Publications and source records attributed to D S Hendawy.

4 recordsLinked to original sources

PubMed1984

'Candida infection in the tongue and pharynx'.

60 patients with chronic pharyngitis were investigated. In all cases the tongue was coated, fissured or hairy. Scrapings from the tongue and swabs from the posteriors pharyngeal wall were examined for the presence of Candida albicans. In the tongue cultures were positive in all cases, and in the pharynx they were positive in 42 cases. After treatment with 'Canasten' solution, the condition was cured in 53 cases. This directs attention to the role of Candida albicans as a cause of chronic pharyngitis, and to the relationship between candidiasis of the tongue and that of the throat.

Adult↗

PubMed1982

Otomycosis: an experimental evaluation of six antimycotic agents.

One hundred-and eight-six fungi were isolated from one hundred-and-eighty cases clinically diagnosed as otomycosis. They comprise 59 species of 26 genera of moulds, and 2 genera of yeasts. This large variety of mould isolates provided ample material for in vitro experiments, to evaluate the anti-fungal activity of six antimycotic substances found in the preparations currently used for the treatment of otomycosis. The antifungal activity of clotrimazole and tolnaftate in vitro was evident. For over 94 per cent of the 59 fungus species tested, the MIC was less than 0.1 micrograms/ml, and for 6 per cent it was between 0.4 and 1 microgram/ml. Concerning the other 4 antimycotic substances (iodochlorhydroxyquin, fluonilid, natamycine and polymyxin B sulphate) the MIC ranged from greater than 100 micrograms/ml to 1 microgram/ml for the majority of tested fungi. The clinical observations were mostly in accordance with these findings.

Antifungal Agents↗

PubMed1982

Non-invasive antromycosis: (diagnosis and treatment).

Increasing numbers of cases of chronic maxillary sinusitis are encountered which resist frequent sinus irrigation and treatment of predisposing factors. The antral washouts are of unusual consistencies and colours. The antral washouts of six cases were investigated by culture and microscopic examination and proved to contain fungal colonies. Antroscopy was a valuable asset in diagnosis. One patient had a Caldwell-Luc operation and daily irrigation through an indwelling polythene tube followed by daily instillation of clotrimazole (Canesten). The five patients who refused operation were treated by repeated bi-weekly antral washouts followed by instillation of clotrimazole. Weekly samples of antral secretions were examined by culture and microscopic examination until they were free for four consecutive weeks. We believe that frequent antral irrigation and local instillation of a broad-spectrum antimycotic drug--preferably after debridement--is the treatment of choice for antromycosis.

Adult↗

PubMed1982

Tonsillomycosis: a myco-histopathological study.

Tissues from 227 tonsillectomies, mainly in adults, were examined culturally and histopathologically for the presence of fungus. Actinomyces was demonstrated in 69 cases (30.40 per cent) by both methods. Yeasts and moulds were each isolated from 21 cases (9.25 per cent) and mixed isolates were obtained from 7 cases (3.08 per cent). There was no histopathological evidence of these organisms. Negative cultural and histopathological results were obtained in 53 cases (23.35 per cent). Chloramphenicol-resistant bacteria were cultured in 56 cases (25.11 per cent) but were seen histopathologically in only 25 cases (11.01 per cent). In all cases in which Actinomyces or bacteria were present histopathologically, a minimal tissue response indicated that these organisms were saprophytes and not primary pathogens.

Actinomyces↗