Biomedical subjects
Publications and source records attributed to D S Hopton.
A multicentre study was conducted to assess the degree of agreement between pathologists grading breast tumours using the WHO criteria. Satisfactory correlation of grades was found to occur with observer variation of 21.9% on 874 tumours.
The influence of histological grade on the recurrence and mortality of patients with breast cancer is reported for 829 patients. The effect of the histological grade is also compared with the effect of axillary node involvement and the implications for clinical studies of the management of breast cancer discussed. The prognosis for both recurrence and death becomes increasingly poor as the degree of differentiation decreases, as reflected by the grading allocated to the tumour. This effect is independent of the clinical stage of the cancer at the time of treatment.
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The effect of intravenous metronidazole as prophylaxis against postoperative wound infection was studied in a prospective, randomized, double-blind controlled trial of 116 patients undergoing elective cholecystectomy. No significant difference was found in the infection rate between the treated and the control groups.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.