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Biomedical subjects

D S Lloyd

Publications and source records attributed to D S Lloyd.

5 recordsLinked to original sources
PubMed1979

Visual and computer-assisted assessment of the EEG in epilepsy of late onset.

A study was made of 275 patients presenting with suspected epilepsy after the age of 20 years. In 122 it was concluded that the attacks were non-epileptic. In 60 others cerebral pathology was found. If the EEG was visibly abnormal the risk of cerebral pathology was 8 times greater than when the record was normal. The EEGs were also assessed by an automatic pattern recognition technique, which classified them as abnormal by reference to a control population of 300 volunteers. 90% of EEGs from patients with pathology were classified as abnormal and, conversely, 86% of patients with abnormal records (as assessed by the automatic analysis) had pathology.

Adult↗
PubMed1978

Computer-assisted interpretation of clinical EEGs.

A multivariate pattern recognition technique has been developed, to distinguish the EEGs of patients with cerebral pathology from those of normal controls and to localize any abnormalities detected. Two methods of feature extraction have been used, power spectral density and slope descriptor analysis, together with various types of feature compression. These techniques have been evaluated on EEGs from 63 patients with proven pathology. Spectral analysis proved more reliable than slope descriptor analysis and predicted the site of cerebral pathology more accurately than did visual assessment of the EEGs. This apparent improvement over the diagnostic reliability of visual analysis in considered to justify further development and evaluation of this technique.

Adult↗
PubMed1976

The contingent negative variation and psychological findings in chronic hepatic encephalopathy.

Early diagnosis of chronic hepatic encephalopathy (CHE) in the latent stage before the appearance of clinical signs, should reduce both morbidity and mortality as deterioration is often preventable by treatment. Since existing diagnostic procedures are inadequate, we have investigated a test in which morphine is used as a provocative agent and any resulting change in cerebral function assessed by measurement of the CNV in conjuction with a psychological trail test. Twenty six patients were studied, 6 of whom had clinically overt CHE. A significant correlation (P less than 0.05) between the change in CNV amplitude with morphine and the initial CNV amplitude, consistent with the theoretical model of Tecce (1972), was found. However, the CNV and trail test results taken as a whole did not allow even those patients with overt CHE to be distinguished and we conclude that it is unlikely that differing degrees of latent CHE could be detected.

Chronic Disease↗