PubMed Health⌕ Search

Biomedical subjects

D S Madge

Publications and source records attributed to D S Madge.

At least 19 recordsLinked to original sources
PubMed1982

Effects of the bipyridilium herbicides, diquat and paraquat, on in vivo hexose absorption and fluid transfer in adult mice.

1. The effects of single LD50 oral or subcutaneous doses of diquat and paraquat at different time-intervals on in vivo intestinal absorption of glucose and galactose and concomitant mucosal fluid transfer were investigated. 2. Generally, both herbicides retarded the absorption of either monosaccharide, although the effects of the treatments at different time-intervals were sometimes inconclusive. 3. The mucosal fluid transfer was unaffected, as was the fresh or dry intestinal weights or the intestinal length.

Administration, Oral↗
PubMed1980

Campylobacter enteritis in young mice.

Young mice aged 4--6 weeks and old mice aged 24--26 weeks were inoculated with standard, single, oral doses of two strains of human pathogenic 'related' campylobacters and in vitro small intestinal solute absorption and fluid transfer measured 7 days after inoculation. Young inoculated mice showed significantly lowered D-glucose and D-galactose absorption; in old inoculated mice absorption of these solutes remained unaltered. In young inoculated mice absorption of D-glucose was uniformly depressed in the distal four-fifths of the small intestine; absorption in the proximal one-fifth remained unaltered. Fluid transfer from the entire small intestine or segments of intestine remained unchanged 7 days after inoculation.

Aging↗
PubMed1976

Polychlorinated biphenyls (phenoclor and pyralene) and intestinal transport of hexoses and amino acids in mice.

1. Using mouse everted whole small intestine 7 days after a single dose of Phenoclor DP6 (hexachlorobiphenyl) at 1.0 g kg-1 body wt, absorption of D-glucose decreased significantly, probably owing to toxic traces of pentodicholobenzofuran in the PCB preparation and not its high chlorine content. D-glucose tissue accumulation decreased. The serosal fluid transfer also fell but not the gut fluid uptake. D-glucose absorption and fluid transfer remained unchanged following doses of other Phenoclor and Pyralene (PCB) compounds. 2. Using DP6, malabsorption of D-glucose and impaired serosal fluid transfer were not evident 7 days after a single dose of 0.1, 0.25 and 0.50 g kg-1 body wt. One to 21 days after a single dose (1.0 g kg-1 body wt) of DP6, D-glucose absorption and serosal fluid transfer decreased from 3 to 14 days but thereafter became normal. 3. Although absorption of D-galactose, D-glucose following membrane hydrolysis of D-maltose, and L-arginine, L-histidine, L-ornithine and L-proline decreased slightly 7 days after a single dose of Phenoclor DP6,the results were not significant, nor were changes in fluid transfer. 4. Following Phenoclor DP6-treatment, D-glucose malabsorption was abolished by an exogenous energy supply (D-mannose). DP6 affected intracellular metabolism and not the glucose carrier at the membrane brush border. 5. The body-weights and fresh small intestinal weights of mice treated with different PCBs remained unchanged after seven days. The histology of the small intestine showed minimal changes.

Amino Acids↗