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Biomedical subjects

D S Seto

Publications and source records attributed to D S Seto.

At least 19 recordsLinked to original sources
PubMed1987

Pneumonia associated with acute rheumatic fever.

Pulmonary involvement in acute rheumatic fever is rare. Clinical and laboratory findings in rheumatic pneumonia are non-specific. Most of the cases of rheumatic pneumonia described in recent years have had a fulminant course often resulting in death. Autopsy findings are suggestive of but not specific for rheumatic pneumonia. In this article a case of pneumonia associated with acute rheumatic fever is described. Pneumonia and carditis occurred simultaneously in a 10-year-old boy treated without steroids, which resulted in recovery. The clinical spectrum of rheumatic pneumonia can range from mild to fulminant.

Acute Disease↗
PubMed1985

Bacterial and viral pathogens causing fever in infants less than 3 months old.

We studied 182 sick, febrile (temperature greater than 38 degrees C) infants less than 3 months of age, who presented at our Tripler Army Medical Center, Honolulu, during a one-year period, to determine the relative causes of fever in this age group. Blood, cerebrospinal fluid, urine, nasopharyngeal secretions, and stool specimens were cultured for bacterial and viral pathogens. Paired acute and convalescent sera were collected to serologically confirm infection in infants from whom viral isolations were obtained only from the nasopharynx or stool. A viral pathogen was isolated in 75 infants (41%) and a bacterial pathogen was isolated in 27 infants (15%). Nonpolio enteroviruses were the most common pathogens demonstrated. They were isolated from 64 infants (35%), and 40 (62%) of these infants had aseptic meningitis, the most frequently made diagnosis. Urinary tract infection was the most common bacterial infection observed. It occurred in 20 infants (11%) and was most often seen without associated pyuria in uncircumcised male infants. Salmonellosis, the second most common bacterial infection, was observed in six infants (3%), and two of these did not have diarrhea or other gastrointestinal tract symptoms. No infant had septicemia and only one infant had bacterial (group B streptococcal) meningitis.

Bacterial Infections↗
PubMed1984

Hematuria. A suggested workup strategy.

Finding the cause of hematuria is challenging because there are so many possibilities. After conducting a careful history and physical examination, we use the step-by-step plan for laboratory and radiologic testing described here. Referral to a nephrologist is indicated when glomerular or renal parenchymal disease is evident; however, observation is often advisable if a specific diagnosis cannot be made.

Biopsy↗
PubMed1984

Relationships of prostaglandin levels and natural killer (NK) cell cytotoxicity of mononuclear cells in cord blood.

Natural killer cell cytotoxicity of mononuclear cells and the corresponding plasma prostaglandins were examined in cord blood. Low NK cell cytotoxicity was demonstrated against three target cells: NK(K562), NK(HSV-1) and NK(Fs). Prostaglandins of the B, E and F series were examined and found to be higher than adult values. A significant correlation (p less than 0.05) between NK cell cytotoxicity and the prostaglandin F series was demonstrated.

Cytotoxicity, Immunologic↗
PubMed1983

Prostaglandin I2 (prostacyclin) formation in lung tissues of Swiss mice.

The indirect assessment of prostacyclin synthetase by analysis of prostaglandin I2 (PGI2) formation in lung tissues of fetal, newborn and adult Swiss mice was determined by in vitro platelet inhibition. PGI2 was synthesized in fetal, newborn and adult mice lung tissues. A progressive increase in PGI2 synthesis with increasing fetal age was shown. The 11 to 13 days fetal age samples gave PGI2 values of 12.0 and 20 ng per 50 mg lung tissue, respectively. These represented 20% and 33% of the adult mean value of 60 ng. Adult levels of PGI2 were attained in utero at fetal age of 16 days. It is suggested that because of its early appearance in fetal life in the lung tissue, prostacyclin synthetase is an important enzyme in prostaglandin metabolism in the ontogeny of the fetus.

Animals↗
PubMed1983

Prostacyclin (prostaglandin I2) formation in lung tissues of infants in sudden infant death syndrome (SIDS), non-SIDS and adults.

SIDS lung tissues elaborated significantly (p less than 0.01) lower PGI2 as compared with non-SIDS and adults. Significant differences (p less than 0.01) between SIDS and non-SIDS were especially shown at 2-4 months of age, 16.46 +/- 6.86 vs. 28.39 +/- 8.86 ng PGI2/50 mg of lung tissue, respectively, for SIDS and non-SIDS. A highly significant difference (p less than 0.001) was shown for SIDS (16.46 +/- 6.86 ng PGI2/50 mg lung tissue) when compared to adults (33.50 +/- 5.60 ng PGI2/50 mg lung tissue). It is suggested that there is defective maturation in the development of prostacyclin synthetase in lung tissues of SIDS infants.

Adult↗
PubMed1980

Significance of antibody to hepatitis B core antigen in a hemodialysis unit.

Serum hepatitis B surface antigen (HB(s)Ag), antibody to HB(s)Ag (anti-HB(s)) and antibody to hepatitis B core antigen (anti-HB(c)) were determined serially in patients and staff in a hemodialysis unit. A low prevalence of HB(s)Ag (2.8 percent) was found. However, in patients without HB(s)Ag, anti-HB(c) alone was present in 9.2 percent, and coexistent anti-HB(s) and anti-HB(c) in 19.2 percent. In persons with anti-HB(c) only, the levels of anti-HB(c) correlate positively with abnormal results on liver function studies (LFS). In all subjects with abnormal LFS findings, anti-HB(c) levels were greater than 6.04 radioimmunoassay (RIA) units. In subjects with both anti-HB(s) and anti-HB(c), all five subjects with higher anti-HB(c) relative levels had abnormal LFS results and all subjects with normal LFS results had higher anti-HB(s) relative levels. Along with other recent reports in the literature, these findings suggest a hepatitis B prevalence in this hemodialysis unit far in excess of that anticipated on the basis of HB(s)Ag prevalence.

Antibodies, Viral↗
PubMed1979

Viral hepatitis.

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Carrier State↗
PubMed1977

Conjuctivitis and keratoconjunctivitis associated with primary immunodeficiency diseases.

Nineteen patients with a variety of well-defined primary immunodeficiency diseases were examined for ocular abnormalities. Eight patients with low levels, or absence, of all the major serum immunoglobulins had conjunctivitis or keratoconjunctivitis associated with bacterial infection. The remaining 11 patients, who had at least one immunoglobulin class present in normal concentration in the serum, showed no inflammatory ocular lesion. Absence of only IgA, the major tear immunoglobulin, did not predispose the eye to these lesions.

Adolescent↗
PubMed1977

Lower esophageal sphincter dysfunction in esophageal atresia: nocturnal regurgitation and aspiration pneumonia.

The association between lower esophageal sphincter (LES) incompetence, gastroesophageal reflux, and recurrent pneumonia in patients who have undergone successful repair of esophageal atresia (EA) and tracheoesophageal fistula is demonstrated in this study. The efficacy of esophageal manometric examination in the evaluation of the LES in young children after EA repair is documented. This study also provides evidence that infants and children with LES incompetence associated with EA may have LES responsiveness to bethanechol. Once established by manometry, this responsiveness may be used to manage the patient until surgical repair would be advantageous.

Adolescent↗
PubMed1977

Role of lower esophageal sphincter incompetence in recurrent pneumonia after repair of esophageal atresia.

The etiology of recurrent aspiration pneumonitis after the successful repair of esophageal atresia has not been defined. In order to explain this occurrence, we performed esophageal manometric examinations on eight patients who had undergone repair of EA and tracheoesophageal fistula. Two patients who had had recurrent pneumonia had subnormal pressure of the lower esophageal sphincter; they also had a history of severe regurgitation, and a barium esophagram demonstrated free gastroesophageal reflux. The LES incompetence in these patients was apparently corrected by administration of bethanechol.

Adolescent↗
PubMed1977

Fatal ECHO 24 infection in a patient with hypogammaglobulinemia: relationship to dermatomyositis-like syndrome.

Patients with deficient antibody-mediated immunity may develop a rare "dermatomyositis-like" syndrome, which is usually progressive and fatal. We have observed a child with hypogammaglobulinemia in whom a dermatomyositis-like syndrome was associated with a fatal, disseminated ECHO 24 infection. This association suggests that in some immunodeficient patients the fatal dermatomyositis-like syndrome is a manifestation of a viral infection in a compromised host. The use of maternal plasma, with a high titer of ECHO 24 neutralizing activity, was unsuccessful in arresting the progress of the infection.

Agammaglobulinemia↗