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Biomedical subjects

D Saffer

Publications and source records attributed to D Saffer.

31 records · Page 2Linked to original sources
PubMed1983

The sunflower syndrome. A new look at "self-induced" photosensitive epilepsy.

The stereotyped, episodic abnormal behaviour manifested by a child and her mother on exposure to a particular sort of sunlight is described in detail. The child is the first fully documented patient with this so-called "self-induced" form of photosensitive epilepsy in whom for several years no electroencephalographic sensitivity to flickering light could be demonstrated. The probability that the cingulate circuit may be the anatomical substrate involved in the pathogenesis of these patients' unusual response to sunlight is discussed. Both patients also exhibited remarkably persistent habit rhythmias--the one common to both being that of circling.

Adolescent↗
PubMed1983

Frusemide: a safe diuretic during lithium therapy?

This paper reports the effect of frusemide given in therapeutic doses for hypertension in patients receiving prophylactic lithium for affective disorders. It was found that frusemide had no significant effect on plasma lithium concentration in these patients who were studied over a 12-week period. It was concluded that frusemide is a safe diuretic to administer to patients receiving lithium therapy.

Aged↗
PubMed1980

Large-vessel disease in a black diabetic: a case report.

A case of a middle-aged Black woman with maturity-on-set diabetes is described. The patient had had a cerebrovascular accident and subsequently developed thrombosis of the descending thoracic aorta, with extension into the left subclavian artery and emboli in the right femoral and left brachial arteries. Occlusive large-vessel disease rarely occurs in Black diabetics. Vascular disorders and haemostatic factors in Black and White diabetics are discussed.

Adult↗
PubMed1979

Crural hypertrophy associated with centronuclear myopathy.

A case of centronuclear myopathy of adult onset with striking hypertrophy of lower limb muscles in a black South African man is described with details of the light microscopic, histochemical, and ultrastructural features. The association of hypertrophied muscles with centronuclear myopathy has not to our knowledge been reported previously and it is felt that this may be a variant of the condition.

Adenosine Triphosphatases↗
PubMed1978

Hemiplegia and the billowing mitral leaflet syndrome.

Four young patients presenting with major neurological episodes and with coexisting prolapsing mitral valve are described. An attempt at correlating the two entities is made. The neurological complications of prolapsing mitral valve are stressed.

Adolescent↗
PubMed1977

Carbohydrate metabolism in motor neurone disease.

Eight patients with classical motor neurone disease, and eight control patients with neurological disease and matched for degree of wasting, were studied. Both groups had abnormal glucose tolerance, but the patients with motor neurone disease had a significantly lower insulin response both to oral glucose loading and to intravenous tolbutamide. These results suggest that in patients with motor neurone disease there is an impaired synthesis or release of insulin due to islet cell damage. Blood pyruvate and lactate, and cerebrospinal fluid pyruvate, lactate, and citrate, did not differ significantly from the control group. Blood citrate levels were significantly higher in patients with motor neurone disease compared with the controls. Triglyceride levels were raised in patients with motor neurone disease compared to the control patients. This may be secondary to the increased citrate levels.

Adult↗
PubMed1977

The diagnosis and significance of isolated third nerve palsy in the African.

The clinical spectrum of forty-one cases of isolated third nerve palsy in the African (Negro) population is presented. A high proportion (58%) was due to cerebral aneurysm. Other causes were syphilis (15.5%) diabetes mellitus (11%), and ophthalmoplegic migraine (11%). It is evident from this study that, contrary to accepted thinking on this subject, there are no clinical features which reliably distinguish between these groups. Early cerebral angiography is therefore mandatory.

Adolescent↗
PubMed1976

Choriocarcinoma presenting as Jacksonian epilepsy.

Cerebral deposits of choriocarcinoma tend to be multiple and usually result in a rapidly fatal course. Two patients presented with Jacksonian epilepsy due to metastatic choriocarcinoma in the brain. In the first patient, the diagnosis of metastatic choriocarcinoma was unsuspected, since curetted uterine material was normal, the haemagglutination inhibition test for pregnancy was negative and a chest radiograph was unremarkable. A diagnosis of choriocarcinoma was made by brain biopsy 2 days before death. The second patient had been previously treated with systemic chemotherapy (methotrexate and actinomycin D) for uterine and pulmonary choriocarcinoma associated with hyperthyroidism. Human chorionic gonadotrophin could not be detected in the urine when the patient presented with Jacksonian epilepsy. A brain scan showed multiple areas of increased uptake consistent with metastatic choriocarcinoma. She was treated with both systemic chemotherapy and intrathecal methotrexate and cranial irradiation. A complete remission was obtained. Intrathecal methotrexate and cranial irradiation appear to offer a hopeful new approach to the problem of metastatic cerebral choriocarcinoma.

Adult↗