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Biomedical subjects

D Sager

Publications and source records attributed to D Sager.

10 recordsLinked to original sources
PubMed1989

Chlorambucil--an effective corticosteroid-sparing therapy for pyoderma gangrenosum.

A 21-year-old man, with a past history of severe aphthosis and arthritis between age 5 and 15 years, presented at age 18 years with a large leg ulceration, which developed after minor trauma. At that time he was otherwise healthy and taking no medications. Between 1983 and 1986 the patient failed to respond to intensive topical care to the ulcer, two attempted skin grafts, oral prednisone (up to 200 mg/day), sulfasalazine, dapsone (200 mg/day), multiple trials of intralesional triamcinolone acetonide, hyperbaric oxygen, azathioprine, methotrexate, clofazimine, minocycline, and three courses of pulse methylprednisolone therapy. Therapy with chlorambucil (4 mg/day) resulted in progressive improvement and complete healing with eventual cessation of all other therapy. The use of chlorambucil in pyoderma gangrenosum may be an effective adjunctive steroid-sparing therapy.

Administration, Oral↗
PubMed1983

Intracranial haemorrhage in the term neonate diagnosed by computerised tomography--perinatal history, symptoms and outcome.

An intracranial haemorrhage was diagnosed by computerised tomography in 35 term neonates. Subarachnoid haemorrhage was found in 23, intracerebral haemorrhage in 9 and subdural haematoma in 3 patients. Perinatal risk factors indicating trauma or hypoxic events were evaluated in more than 50%. Clinical symptoms were independent of the site of the bleeding. An additional hypoxic-ischaemic brain injury seemed to be the cause of the observed clinical symptoms in many cases. The outcome was significantly better in patients with subarachnoid haemorrhage than in intracerebral haemorrhage or subdural haematoma. Respiratory arrest, increased muscle tone and seizures were frequently associated with an unfavourable outcome.

Asphyxia Neonatorum↗
PubMed1982

A new multiprogrammable isotopic powered cardiac pacemaker.

A new multiprogrammable, isotopic-powered cardiac pacemaker was implanted in six patients as a custom device. Five were initial implants and one was a replacement. The patients were studied for up to two years. In five of the six cases it was found advantageous to change one of the programmable parameters. Multiprogrammability is obviously as important in an isotopic pulse generator as in a lithium unit, if not more so, because of the unit's greater longevity. Further studies are continuing in an FDA approved clinical trial.

Electrocardiography↗
PubMed1981

A programmable pulse generator with high output option.

A new pulse generator, with a programmable high output option, was implanted in fifteen patients and studied for eight to ten months postoperatively. This feature is designed to combat exit block. It was useful in one patient who developed a form of exit block following a silent myocardial infarction. Muscle stimulation was rare, even though the system is unipolar. The high output option seems to be a desirable feature and should probably be available in all multiprogrammable pulse generators.

Aged↗
PubMed1980

[Results of computerized tomography of the skull in hemodialysis patients].

Psychiatric and neurological symptoms as well as the clinical diagnosis of 22 patients on chronic hemodialysis were set in contrast with the findings of the cranial computerized tomography. The cranial computerized tomography turns out to be a valuable diagnostic aid to recognise or exclude morphologic lesions in the central nervous system, particularly because the complex overlap of the various pathogenetic mechanisms in hemodialysed patients points out frequently the little value of the clinical symptoms.

Adult↗