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D Salisbury

Publications and source records attributed to D Salisbury.

At least 19 recordsLinked to original sources
PubMed2006

Immunization campaigns in the UK.

A mass immunization campaign is a rapid vaccination intervention across age groups as opposed to provision through routine vaccination at a specified age attainment. Some countries use campaigns routinely as they have experience that shows that in their health systems higher coverage can be reached through campaigns than by routine service provision. Whilst many industrialized and non-industrialized countries have introduced new vaccines into their routine programme, the UK is unusual in deliberately doing this via campaigns. A number of mass immunization campaigns have been implemented in the UK, either integrated into the routine immunization programme such as the annual influenza immunization campaign; as a catch-up campaign alongside the introduction of a new vaccine into the routine vaccination schedule (MMR, Haemophilus influenzae b, Meningococcal C conjugate vaccine); or as a one-off campaign, to boost immunity in a particular age group, without introducing the vaccination into the schedule routinely at that age (Haemophilus influenzae b). Campaigns require intense planning at national and local level with leadership to achieve proper management. Although the components of an immunization campaign can be described separately--strategic planning, vaccine supply, communication and surveillance; for a programme to be successful integrated planning is essential.

Communicable Disease Control↗
PubMed2003

Chemical composition of lipophilic extractives released during the hot water treatment of wheat straw.

Treatment of wheat straw with hot water at 80-95 degrees C for 0.5 h at pH 6.0-8.0 released 41.0-53.0% of the original lipophilic extractives. The chemical compositions of six lipophilic extractives were determined by GC on a medium-length high-temperature capillary column without derivatization, thus giving a method for direct determination of individual components of free fatty and resin acids, sterols, waxes, sterol esters, and triglycerides. The extracts contained 68.7-75.8% lipophilic substances, comprising mainly free fatty acids (25.8-48.4%), waxes (9.4-27.0%), sterols (4.1-8.0%), triglycerides (3.3-11.0%), and sterol esters (2.6-5.1%). Minor amounts of diglycerides (0.3-0.5%), resin acid (0.5-3.1%), and phenolic compounds (0.9-3.6%) were also quantitatively determined in the extractives.

Chromatography, Gas↗
PubMed2001

Planning, registration, and implementation of an immunisation campaign against meningococcal serogroup C disease in the UK: a success story.

The introduction of meningococcal C conjugate (MCC) vaccine in the UK in November 1999 as a routine 3 dose infant immunisation course, with a single catch-up dose for all children aged between 12 months and 17 years, was the result of an intensive 5 year collaborative research programme funded by the Department of Health for England and involving public bodies, academia and vaccine manufacturers. The research programme established the safety and immunogenicity of MCC vaccines in infants, toddlers, pre-school and school-aged children. The nature and frequency of common adverse events in school-aged children was similar to that after a booster dose of diphtheria and tetanus vaccine given to the same age groups. The recommendation that a single dose was adequate for children aged 12 months and above was based on antibody levels measured by serum bactericidal assay and evidence of induction of immunological memory as shown by maturation of antibody avidity. Licensure by the Medicines Control Agency was based on serological criteria alone without direct evidence of efficacy and has set a precedent for other meningococcal conjugate polysaccharide vaccines. Vaccine coverage of around 85% was achieved in the targeted age groups and has resulted in a drop in the incidence of serogroup C disease in these groups of over 80% within 18 months of the start of the vaccination programme. Early post-licensure efficacy estimates for toddlers and teenagers (88 and 96%, respectively, in the first 16 months after vaccination) validate the serological criteria used for licensure. Surveillance of the prevalent serogroups and serosubtypes among invasive case isolates has shown no evidence of any capsular switching to serogroup B during the first 18 months of the MCC vaccination programme.

Humans↗
PubMed2001

Introduction of a conjugate meningococcal type C vaccine programme in the UK.

OBJECTIVE: The purpose of the UK initiative was to accelerate the development and introduction of new conjugate meningococcal C vaccine into the routine immunisation programme, and to implement a catch-up campaign based on the disease epidemiology. METHODOLOGY: Collaboration between Government supported institutions and the vaccine industry lead to a collaborative programme of research designed to answer policy specific questions and to accelerate the availability of new vaccines. RESULTS: Three new conjugate meningococcal C vaccines were developed and licensed for use in the UK after satisfactory data on safety and immunogenicity had been generated. A nationwide campaign was designed to offer vaccine to all infants at the same time as their three doses of primary immunisations, two doses were offered to children over 4 months and under 1 year old; all those over 1 and under 18 years old were offered a single dose of vaccine. The programme was on course for completion within approximately twelve months, with around 15 million immunisations being offered. The programme was implemented simultaneously through school and primary care services. CONCLUSIONS: A safe and effective new vaccine, against group C meningococcal disease, has been introduced into the UK immunisation programme after just a 5 year development to implementation process. Early indications point to high coverage and impacts on disease are already apparent in the groups that have been immunised. These vaccines may play an equally important role in other countries where there is a significant burden from Group C meningococcal disease.

Humans↗
PubMed1998

Certifying the elimination of poliomyelitis from Europe: advancing towards global eradication.

UNLABELLED: Indigenous wild polioviruses have been virtually eliminated from the 51 countries of the European Region of the World Health Organization (WHO), an achievement that is of critical importance to the global initiative to eradicate poliomyelitis by the year 2000. An international commission has been established to certify the elimination of poliomyelitis from this region. European countries have recently been requested to establish National Certification Committees to review and submit the necessary documentation and surveillance data. In some Western European countries where polio has not been reported for many years, the challenge will be to produce robust evidence demonstrating both the current absence of wild poliovirus and the means to promptly detect and respond to possible importations of wild poliovirus for the next several years, up to global eradication and the cessation of polio vaccination. KEY MESSAGES: 1. laboratory-based surveillance with collection of faecal specimens is necessary to demonstrate the absence of indigenous wild poliovirus 2. certification can only occur after all countries have demonstrated the absence of indigenous wild polioviruses for at least 3 years and have the means to detect and respond to importations of wild poliovirus for several years into the future 3. any single case of poliomyelitis in Europe now requires an immediate public health response which includes virological investigation and prompt notification to the World Health Organization.

Certification↗
PubMed1997

Neuropsychological dysfunction in schizotypal personality disorder: a profile analysis.

In order to examine the neuropsychological profile of schizotypal personality disorder (SPD), we studied a wide array of cognitive functions in 10 right-handed men who met DSM-III-R criteria for SPD and 10 matched normal controls. Cognitive functions included abstraction, verbal and spatial intelligence, memory and learning, language, attention, and motor skills. Neuropsychological profiles were constructed by standardizing test scores based on the means and standard deviations of the normal control group. SPD subjects showed significant decrements in performance on the California Verbal Learning Test, a word-list learning measure which requires semantic clustering for more efficient performance, and on the Wisconsin Card Sort Test, a measure requiring concept formation, abstraction, and mental flexibility. These results suggest possible areas of specific neuropsychological dysfunction in SPD, and are consistent with current hypotheses of left-temporal and prefrontal brain dysfunction in schizophrenia.

Adult↗
PubMed1996

Utilizing quality assurance as a tool for reducing the risk of nosocomial ventilator-associated pneumonia.

A multidisciplinary group was formed to develop strategies to reduce ventilator-associated lower respiratory tract infections (LRI) in an intensive care unit (ICU) of a 540-bed acute care teaching medical center. The group process was facilitated by the Infection Director and the quality management specialist. The group was made of medical, nursing, and respiratory therapy staff. Quality improvement techniques were used to define the process of care for ventilated patients in the ICU. "State of the art" care was defined after a literature review and brainstorming sessions. Current practice and new concepts were then forged into a realistic protocol for the ICU. The resulting protocol was introduced into the ICU in May 1992. The information was communicated to Respiratory Therapy and ICU staff in writing and at department meetings. After a 4-month introductory period and learning curve process, a decrease in the endemic rate of ventilator-associated LRI was reduced in the fourth quarter of 1992. The mean 1993 LRI rate was 21 LRI/1000 ventilator days versus 26 LRI/1000 ventilator days in 1992 before protocol implementation. This equates to 18 LRI prevented in 1993. This represents a savings of $126,000. There was a significant decrease in the process variation of the monthly mean LRI/1000 ventilator days in 1993 from 1992. To date, there continues to be improvement with a mean of 16 LRI/1000 ventilator days reported in 1994. The ICU staff developed a multidisciplinary process evaluation and monitored staff implementation of the protocol over time. The results of the evaluation were used as feedback to measure protocol implementation. This was found to improve compliance with the protocol. Both the process (care of ventilated patients) and the outcome (number of LRI) have been improved through use of continuous quality improvement concepts and transdisciplinary interventions.

Clinical Protocols↗
PubMed1993

Response properties of long-latency event-related potentials evoked during NREM sleep.

The experiments reported here sought to investigate whether the K-complex evoked during sleep is comprised of activity from two separate physiological systems with different response properties. To that end, the parameters of stimulation in a two tone auditory 'odd-ball' task were varied systematically as stimuli were presented to subjects during NREM sleep. During experiment 1, the frequency (pitch) of the odd-ball stimulus varied systematically while intensity (loudness) was matched between tones. During experiment 2, pitch was matched between tones while the loudness of the odd-ball stimulus was varied. The long-latency event-related potentials (ERPs) N2 and P3 could be dissociated from the K-complex (N3 and P4) in response to these parametric manipulations. Information processing occurs during sleep, and is reflected in ERPs with a morphology largely analogous to those observed under similar conditions while subjects are awake. The second (K-complex) system is sleep specific. A model was constructed to explain the activity of these two hypothesized systems. As predicted by the model, K-complex latency was longer in Stage 2 when N2 and P3 were also active, than in Stage 4 where N2-P3 activity was lessened. These results support the two-system hypothesis; electrical brain activity evoked during sleep should not be considered a unitary sleep-specific response. Furthermore, the data indicate that the K-complex is sensitive to the physical characteristics of stimuli, that the sleeping brain processes information to a high degree, and that the 'endogenous' components of the ERP observed in awake humans reflect more automatic processes than previously suspected.

Journal Article↗