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Biomedical subjects

D Samson-Dollfus

Publications and source records attributed to D Samson-Dollfus.

At least 37 records · Page 2Linked to original sources

Positive rolandic sharp waves and periventricular leukomalacia in the newborn.

Four cases of periventricular ischemia without hemorrhage in premature infants are described in which positive rolandic sharp waves (PRSW) were predominant in the electroencephalogram (EEG). These findings suggest the relationship of PRSW to periventricular ischemia rather than to intraventricular hemorrhage, per se, as has been considered by most investigations in the past. These PRSW can provide an early indication of periventricular leukomalacia.

Electroencephalography

The value of serum IgE assay in milk aspiration and the sudden infant death syndrome.

Global serum levels of IgE (PRIST, Phadebas) and specific anti-cow's milk IgE (RAST) were measured in populations of infants with a history of one or more episodes of milk aspiration (n = 12), victims of the sudden infant death syndrome (SIDS) (n = 18), "near miss" SIDS infants (n = 23), siblings of a SIDS victim ((n = 21) and control infants (n = 38). Only the infants with a past history of milk aspiration had significantly raised global and specific IgE. The absence of raised specific IgE in the subjects who died from SIDS argues against the hypothesis of sensitisation to cow's milk proteins during a previous episode of aspiration. Nasopharyngeal reflux is frequently seen in near-miss infants. This reflux is more often responsible for reflex apnoea due to stimulation of the laryngeal chemo-receptors than to a fatal aspiration.

Animals

Sudden infant death syndrome in a twin: a comparison of sibling histories.

To determine possible characteristics of infant victims of sudden death, we examined 114 items related to the pre- and postnatal histories of 42 pairs of twins one of whom died of sudden infant death syndrome (SIDS) leaving a surviving sibling. Interviews with the parents were conducted after the occurrence of SIDS, and the data were checked with records held by gynecologists and pediatricians. To evaluate the specificity of any factors, we studied a control group of 42 age- and sex-matched pairs of twins, both of whom survived the first year of life. Only 11 of 114 characteristics were significantly related to SIDS: future victims had a smaller weight and height at birth, stayed longer in the nursery, and followed a moving object with their eyes, had head control, and smiled at a later age than their surviving siblings. They also fatigued more often during feeding (11/42) and had reduced arm and neck tonus (9/42). They were described as longer sleepers than their surviving siblings. During sleep, some SIDS twins, but no surviving twin, were found to be cyanotic at least once or pale (4/42) and were repeatedly covered with abundant sweat (8/42). In the control group of normal twins, the occurrence of most of these characteristics was found with a frequency comparable to that seen in the SIDS infants; the specificity of these characteristics is thus considered doubtful. The mean birth weight and height were significantly greater in the control group, and no control infant had an episode of cyanosis or pallor or repeated episodes of profuse sweating observed during their sleep.(ABSTRACT TRUNCATED AT 250 WORDS)

Body Height

[Flash-pattern visual evoked potentials and limited lesions of the occipital lobe].

Four patients with restricted lobe lesions and one patient with large occipital lesions were selected for VEP studies to full-field and half-field flash pattern stimuli. The abnormalities of the responses were more important with full-field stimuli. In three patients with inner side occipital lobe damage, the P100 component disappeared ipsilaterally to the lesion, but N140 remained normal on bilateral occipital leads. In one patient with outer side occipital lobe damage, P100 was normal on bilateral occipital leads, but N140 disappeared ipsilaterally to the lesion. In one patient with large occipital lesion, P100 and N140 both disappeared ipsilaterally to the lesion. It appears that the P100 component is related to the inner and that N140 is related to the outer area of the occipital lobe.

Adult

[EEG recorded during the 1st 48 hours after a cerebral vascular accident as a result of carotid stenosis].

This article describes the principal EEG abnormalities noted during the first 48 hours of cerebro-vascular ischemic accidents due to carotid artery obstruction. No instances of slow delta waves were seen in the 60 cases of transient ischemic accident. In the 162 cases of cerebro-vascular accidents, all EEG abnormalities were correlated with the level of consciousness and thus add little to the clinical data with respect to the prediction of short-term mortality. However, in the 135 patients who presented a cerebro-vascular accident with no alterations of consciousness, the appearance of polymorphic delta waves or spikes (focalized or diffuse) within the first 48 h does significantly predict short-term mortality.

Brain Ischemia

Analysis of background activity.

Analysis of EEG background activity in epilepsy has been much less used than automatic detection of paroxysmal figures. However, it would be useful to study the background activity with precision. The techniques used can belong to the time domain or the frequency domain. They make it possible to study the variations of EEG background activity as a function of the drug therapy and the type of epilepsy; some prognostic indices can then be derived for different kinds of epilepsy. It seems probable that topographic displays of background frequency bands will be very interesting in the near future. Finally, automatic analysis of sleep recordings in epileptic patients also makes it possible to test drug effects and modifications of sleep stages, as a function of the type of epilepsy.

Action Potentials

A critical comparison of the history of sudden-death infants and infants hospitalised for near-miss for SIDS.

To determine whether significant historical differences distinguish the near-miss for Sudden Infant Death from the infants who died of SIDS, we analysed the histories and clinical data from two groups of infants seen in our University Hospital and from collaborative research group. The data were obtained with the use of a standardised questionnaire and consultation of all available medical data. Sixty-five infants were identified as near-miss for SIDS after they had suffered a severe cardiorespiratory incident during sleep for which no cause could be found despite a complete medical examination. After an autopsy had failed to reveal a cause for the unexpected death 95 cases of SIDS were retained in the study. A series of 353 variables were collected from the parents, the gynaecologists, neonatologists and attending physicians. After statistical analysis, only 15 of the 353 items studied significantly differentiated between the two groups. A step-wise discriminant analysis performed on these items led to the identification of six independent variables: the time of the incident; the circumstances leading to the observation of the child; the child's sleep position; previous minor intestinal problems; the size of the family and the mother's coffee consumption. Most variables indicate that the near-miss infants were discovered and rescued earlier than the infants who died. No other historical information appeared significantly to differentiate between the two groups of infants. These data need confirmation from a prospective epidemiological survey.

Family Characteristics

Electroencephalograms in basilar artery migraine.

Nine cases of 'basilar artery migraine' (BAM) have been recorded. In 8 cases, excess of beta activity was observed during the attacks and disappeared in less than 3 days. The inter-ictal EEGs were normal. Drug ingestion was excluded each time. These EEG patterns are different from those which have been reported in the literature, i.e., transitory posterior abnormal slow waves. However, case no.1 is in agreement with the literature. The expression 'BAM' probably covers different syndromes which are further discussed.

Adolescent

[Dissociation of visual evoked responses to hemi-field or full-field flash-checkerboard stimulation].

Unexpected visual evoked responses (VERs) were recorded in 5 subjects with tumoral, ischemic or hemorrhagic lesions of the retrochiasmatic visual pathways. The flash pattern stimulation was always binocular and involved full-field and half-field stimuli. In these 5 cases, the total field VER was asymmetrical with anomalies on the affected occipital region. However half-field VERs P100 contralateral to the stimulus were noted both on the normal and on the affected occipital region. One can ask if this is not an electrophysiological equivalent of the clinical relative hemianopsia.

Adult

Sudden unexpected infant death in a French county.

We report a study of sudden unexpected infant death (SUID) in a French county (Seine-Maritime) between 1978 and 1981 (rate of 2.71 per 1000 live births). The results agree with those of previous studies concerning sex ratio, seasonal variation, and peak age of death. No relation between gestational age and age of death was found. A comparison with matched living control infants was performed for 136 of the 207 total deaths for whom computerised medical data were available. Significant differences were found between these two groups in gestational age, birthweight, admission to a paediatric ward at birth, and proportion of single mothers. In analysing birthweight and gestational age separately, the birthweights of SUID cases were significantly lower than those of controls, whatever the gestational age. The converse was not true, however: in classifying infants by birthweight, a significant difference between the gestation period of SUID victims and controls was found only for low birthweight infants (less than 2500 g). It is considered that it may be possible to identify infants at particular risk of SUID within the group of babies admitted to hospital at birth for major problems, and a study is currently underway among infants born in Seine-Maritime in 1982.

Age Factors

[Spectral analysis of fast EEG rates in normal 6-to-16-year-old children].

Spectral analysis of EEGs from 208 school children aged from 6 to 16 shows two types of beta activity: anterior beta which is low in amplitude but increases in energy in response to eye opening and posterior beta which, like alpha, decreases in response to eye opening. After reviewing the role of the FFT in frequency analysis we conclude that anterior beta activity corresponds to the classic beta rhythm of visual analysis, while posterior beta activity probably represents harmonics of alpha or even theta activity. In any case, beta activity in the normal child is very low in amplitude and energy.

Adolescent

[Electrophysiologic study of neonatal hypoglycemia prolonged by hyperinsulinism].

A case of neonatal hyperinsulinism with hypoglycemia is reported. The EEGs were abnormal because of a lack of sleep modulation. The CT scan showed pathological occipital hypodensities. The flashes VER were abnormal at 1, 2 and 6 months of age, chiefly on the right occipital lead and showing a possible lesion of the right retrochiasmatic pathways.

Brain

Delta, theta, alpha and beta power spectrum of sleep electroencephalogram in infants aged two to eleven months.

Automatic sleep EEG analysis was performed on infants from 2 to 11 months of age. Partial power spectra of delta, theta, alpha, and beta 1 bands were studied as function of sleep stages, age, and time of the night. beta 1, alpha, and delta power spectra are significantly lower in paradoxical sleep (PS) than in quiet sleep (QS) whatever the age; but theta is lower in PS than in QS only after 5 months of age. delta, theta, and alpha power increase with age in QS. Only delta and theta are greater in the first half of the night than in the second half. beta 1 power does not differ significantly in stages 2 and 3 of QS, during the course of the night or as a function of age. Thus delta, theta, alpha may be the best spectral parameters for the maturation of quiet sleep EEGs during the first year of life.

Alpha Rhythm

[Realization of a system which permits automatic analysis of sleep of infants (2-12 months)].

We have developed a system which permits automatic analysis of sleep of infants from 2 to 12 months of age. It is based on the calculation of a score on the basis of 6 parameters weighted according to their importance in determining the different phases of sleep. We use 3 EEG parameters derived from spectral analysis of the Cz-Oz derivation: total spectral energy (Hjorth activity), energy of the delta band, and energy of the beta band, and 3 polygraphic parameters: variability of muscle activity in each minute, variability of the respiratory frequency and presence or absence of rapid eye movements. The analysis provides a list of the sleep phases, minute by minute, and a traditional sleep diagram; we also calculate the successive appearances of the different sleep phases, in 10 min periods, and schematize these results in a diagram which shows the general trend of each sleep phase during the night. When compared with visual analysis, these results are satisfactory, since we observe on average 86.2% agreement in the differentiation of calm, paradoxical and transitional sleep, and 76.4% agreement in the differentiation of stages II, III and IV of calm sleep.

Electroencephalography

[Several cases of EEG registration of epilepsy induced by television].

We present 6 cases of television epilepsy; there appear to be 2 distinct populations. The first group has seizures only when near the screen, is sensitive to the alternating appearance of odd and even lines and most often is not sensitive to photic stimulation at 50 Hz; the second group has seizures far from the screen and is sensitive to photic stimulation at 50 Hz. Therapeutic approaches are discussed for both groups.

Adolescent

[Electroencephalographic surveillance during carotid endarterectomy].

Continuous EEG monitoring during 110 carotid endarterectomies showed transient or permanent abnormalities in 35 cases. In 13 cases, these abnormalities occurred during carotid clamping and led the surgeon to place a shunt in 8 cases. In 22 cases, electrical abnormalities of various types appeared outside the clamping period. Continuous EEG monitoring demonstrated that cerebral disturbances can occur at any time during the operative period. Thus, intra-operative EEG monitoring allows a better understanding of clinical signs which may be seen postoperatively.

Anesthesia, General