Pathologic quiz case 1. Seborrheic keratosis, irritated type.
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Ear Canal↗
Biomedical subjects
D Saporta
Publications and source records attributed to D Saporta.
Type II collagen induced bone resorption in the temporal bone of rats: histological and immunohistochemical studies.
Bone resorption in the temporal bone of rats was induced by peripheral immunizations of heterogeneous type II collagen. Bone resorption was found at both the tympanic bone and the petrous bone of the otic capsule. Macrophages, fibroblasts and osteoclasts were found in the enlarged spaces of bone. Immunohistochemical studies demonstrated that macrophages, fibroblasts and osteoclasts produced collagenase and prostaglandins in the bone resorption processes, suggesting that these cells are responsible for the resorption observed.
Animals↗
Immunologically induced salpingitis in rats.
Eustachian salpingitis was induced with type II collagen in rats. The inflammatory reaction spread from the tubal submucous layer toward the surrounding tissue. Lymphocytes and plasmacytes were the major cells found in the inflammatory infiltrates. Bone resorption with many osteoclasts and mononuclear cells infiltrating into the muscle were also observed. These findings suggest that an immune response against type II collagen can induce eustachian salpingitis.
Acid Phosphatase↗