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Biomedical subjects

D Schlossberg

Publications and source records attributed to D Schlossberg.

At least 19 recordsLinked to original sources
PubMed1991

Aortitis caused by Mycobacterium fortuitum.

Aortic valve replacement was complicated by sternal wound infection with Mycobacterium fortuitum. The wound was treated with débridement and antibiotic therapy. Five months later the patient developed fever, and blood cultures yielded M fortuitum. At surgery, aortitis with pseudo-aneurysm formation was encountered. Mycobacterium fortuitum grew from the aortic lesion. This is the first report of M fortuitum causing aortitis, although this organism is known to infect sternal wounds and mediastinum. Mediastinal infection can progress despite a normal wound appearance. Its manifestations may be delayed and may include infections of the aorta as well as of the sternum and mediastinum.

Aortic Valve↗
PubMed1989

Culture-proved disseminated cat-scratch disease in acquired immunodeficiency syndrome.

A male homosexual (positive for the human immunodeficiency virus) with a recent cat scratch developed fever, epitrochlear and axillary lymphadenopathy, and retinitis. Subsequently, he developed skin (epitheloid hemangioma) and mucosal lesions (Kaposi's sarcoma), multiple liver abscesses, and pleural effusion. Warthin-Starry stains and/or electron micrographs of lymph nodes and skin lesions demonstrated bacilli characteristic of those associated with cat-scratch disease. Cultures of lymph node, pleural fluid, and liver abscess specimens yielded organisms believed to be the causative agent of cat-scratch disease. We believe that disseminated cat-scratch disease may become an indicator of opportunistic infection signaling acquired immunodeficiency syndrome in a patient who is positive for the human immunodeficiency virus.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Periampullary, colorectal and gastric cancer in two siblings.

We describe a sibship affected by subsequent periampullary, colorectal and gastric carcinoma. Three of 4 siblings (2 males, 1 female) developed a periampullary carcinoma at the age of 20, and the 2 brothers subsequently had colorectal and gastric carcinoma. One of them also had familial adenomatous polyposis. There is suggestive evidence of vertical transmission of a gene predisposing to a hereditary colorectal carcinoma syndrome.

Adult↗
PubMed1988

Varicella pneumonia.

Six normal adults with varicella pneumonia were treated successfully with acyclovir sodium. All patients showed resolution of roentgenographic and arterial blood gas abnormalities. In addition, five of the six patients demonstrated thrombocytopenia that resolved with therapy. Intravenous acyclovir therapy should be instituted as early as possible in patients who may have varicella pneumonia.

Acyclovir↗
PubMed1987

[Radiotherapy of esophageal carcinoma. Results checked clinically by radiology, endoscopy, biopsy and autopsy].

Forty-four patients with histologically confirmed esophageal cancer were irradiated with 60 Gy, checked endoscopically and by biopsy, and then followed clinically or radiologically until their death. The findings confirm the local destructibility of esophageal cancer with loosely ionized radiation and a favorable effect on quality of life. Three quarters of the patients were able to take normal food at the end of the radiotherapy, while the remainder were at least able to swallow soft foods. Radiotherapy can be offered as an effective alternative to patients, especially when operation is associated with a high risk. This is also demonstrated by the fact that 23 of 32 patients who had endoscopy and biopsy again at the end of the radiotherapy had no histologically demonstrable tumor.

Adenocarcinoma↗
PubMed1987

Disseminated sarcoidosis.

A patient with sarcoidosis manifested by skeletal and cutaneous involvement had a normal chest x-ray and gallium scan of the lungs. The absence of pulmonic disease in spite of the extrapulmonic manifestations of sarcoidosis is rare. A normal chest x-ray does not exclude the diagnosis of sarcoidosis.

Adult↗
PubMed1987

Legionella-like organisms.

The family Legionellaceae contains the new genus and species Legionella pneumophila; organisms that resemble L pneumophila but differ in one or more phenotypes are called legionella-like organisms and constitute a growing list of new species now numbering over two dozen, and the characterization of additional species of legionellae continues to expand. Similar to L pneumophila, some of these new species have additional serogroups within the species. These new species have varying degrees of clinical and epidemiological importance. We will review historical, laboratory, and clinical aspects of Legionella species other than L pneumophila and L micdadei.

Humans↗
PubMed1987

Syphilitic hepatitis: a case report and review of the literature.

Although recognized for more than 400 yr hepatic complications of syphilis are uncommon and frequently overlooked as explanations for acute liver dysfunction. We describe a case of acute hepatitis during the course of relapsing secondary syphilis, with additional confirmation of the diagnosis by lymph node biopsy demonstrating Treponema pallidum.

Acute Disease↗
PubMed1979

Septicemia caused by DF-2.

Fatal septicemia due to an unidentified gram-negative rod developed in a 60-year-old alcoholic. Infection due to this organism has been reported only rarely in the medical literature. Like Pasturella multocida, this organism is related to dog bites, is gram negative, and is sensitive to penicillin.

Alcoholism↗
PubMed1978

Possible use of frequency-pulse-modulated electron capture gas-liquid chromatography to identify septic and aseptic causes of pleural effusions.

Frequency-pulse-modulated electron capture gas-liquid chromatography was used in conjunction with appropriate derivatization procedures to obtain chromatograms from extracts of pleural effusions. These chromatograms were used to rapidly classify the various types of pleural effusions. With this method we have been able to distinguish among a limited number of effusions caused by congestive heart failure, Mycobacterium tuberculosis, and some other types of bacterial empyemas and pleural effusions.

Chromatography, Gas↗
PubMed1977

Bowel perforation with candidiasis.

Spontaneous multiple jejunal perforations developed in a relatively normal patient. Candida albicans was cultured from a biopsy specimen of an area of perforation and from peritoneal fluid. Yeasts and pseudohyphae were seen deep within the necrotic mucosa. Serial determinations of precipitating and agglutinating antibodies support the diagnosis of invasive candidiasis causing this unusual presentation.

Adult↗
PubMed1977

Military rubella.

An epidemic of rubella in 46 young adults occurred. Detailed descriptions of clinical signs and symptoms, basic laboratory evaluation and serologic investigation are provided. None of the vaccinees who became ill lacked IgM antibody. An interesting clinical observation was the 25% incidence of testicular pain.

Adolescent↗
PubMed1977

Spinal epidural abscess.

This paper describes problems in the diagnosis and management of six patients with spinal epidural abscess. Since the clinical findings in this disease process are frequently misinterpreted, one must be careful to exclude this diagnosis in any patient with fever, leukocytosis, back pain and recent infection or back trauma. Alcoholic patients, in particular, seem at high risk for missed diagnosis since the clinical findings are frequently misinterpreted to be complications of alcoholism. Suspicion of spinal epidural abscess should lead to immediate lumbar puncture with manometrics as well as myelography. Once the diagnosis is established surgery should be immediate. Gram stains and cultures taken at the time of lumbar puncture or at operation will dictate appropriate antibiotic therapy. The cause of infection can be fairly well determined by the location of the abscess and a knowledge of the pathogenesis. Prognosis seems directly dependent on the preoperative neurologic status of the patient.

Abscess↗
PubMed1977

Rapid diagnosis of lymphocytic meningitis by frequency-pulsed electron capture gas-liquid chromatography: differentiation of tuberculous, cryptococcal, and viral meningitis.

Cerebrospinal fluid specimens from patients with tuberculous (17 cases), cryptococcal (15 cases), and viral (14 cases) meningitis were analyzed by frequency-pulsed electron capture gas-liquid chromatography and mass spectrometry. Compounds that disappeared after therapy were found to be present in each of these specimens and were not detected in controls. They occurred in repetitive patterns such that these three types of meningitis could be rapidly distinguished. The compound associated with tuberculous meningitis has been tentatively identified. These finding have implications for rapid diagnosis, pathophysiological studies, and possible new therapeutic approaches.

Chromatography, Gas↗
PubMed1976

Possibility of diagnosing meningitis by gas chromatography: cryptococcal meningitis.

Cerebrospinal fluid (CSF) from eight patients with cryptococcal meningitis, from ten patients with viral meningitis, and from four control patients without meningitis were analyzed by electron-capture gas-liquid chromatography (EC-GLC). All cryptococcal specimens had similar EC-GLC profiles, and these differed from those of the controls. Viral EC-GLC patterns were different from those obtained with specimens from the patients with cryptococcal infection and from the controls. In addition, specimens from patients with various types of viral infections gave profiles that differed from each other. Two normal CSFs were inoculated with Cryptococcus neoformans; aliquots of these cultures showed an EC-GLC pattern very similar to that seen in CSF of patients with cryptococcal meningitis. The EC-GLC procedure is rapid, reproducible, and easy to perform and may hold promise as an additional aid in the diagnosis of cryptococcal infection.

Cerebrospinal Fluid↗