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Biomedical subjects

D Schoen

Publications and source records attributed to D Schoen.

At least 19 recordsLinked to original sources
PubMed1997

Interleukin-6 is not altered in cerebrospinal fluid of first-degree relatives and patients with Alzheimer's disease.

We investigated interleukin-6 (IL-6) levels in cerebrospinal fluid (CSF) of 25 patients with clinically diagnosed sporadic Alzheimer's disease (AD) and 19 healthy control subjects (HC). For comparison 19 clinically healthy subjects with at least one first-degree relative with clinical or autopsy confirmed AD (CF/AD) were examined. CSF levels of IL-6 did not show statistically significant differences between AD patients, CF/AD and HC subjects. There was no correlation between age, gender, age of onset, degree of cognitive impairment, blood-brain barrier dysfunction and IL-6 values. We could not demonstrate altered CSF concentrations of IL-6 that may indicate an inflammatory response or capability to support neuronal survival in the central nervous system (CNS) of first-degree relatives and patients with AD. We suggest that combined measurement of all parameters of the IL-6-receptor complex could yield more insight in a probably altered IL-6 function.

Adult↗
PubMed1996

Annals of conflicting results: looking back on electromagnetic field research.

Few environmental health issues are as contentious as the question of whether exposure to electromagnetic fields (EMFs) from power lines increases cancer risk. Among the many actors in this controversy, epidemiologists have played the leading role in raising the question and motivating research. Epidemiologic studies of the effects of exposure to power-line EMFs include the investigation by Dr. Gilles Thériault and colleagues into incidence rates of cancer among electric-utility workers in Quebec, Ontario and France. With the development of personal dosimeters to measure exposure to electric, magnetic and pulsed EMFs, occupational studies in the 1990s have made an important methodologic advance. But, as Thériault explains, improvements in assessing exposure have not yet translated into clear and consistent findings.

Canada↗
PubMed1982

[Diagnostic significance of the colloid concentration in the static liver scintigram].

The count density in the right liver lobe is presented as a parameter for the recognition of diffuse parenchymal diseases of the liver by means of static colloidal scanning. Sensitivity, specificity, and accuracy (87-100%) in separating normal from parenchymal damage and cirrhosis are comparable to the results of dynamic sequence scanning. Since this parameter is easy to be measured it is proposed for clinical application.

Chronic Disease↗
PubMed1979

[Panel discussion: problems of the specialist's duty to inform the patient (author's transl)].

The obligation of the physician to inform the patient--which he has to prove in case of a suit--is based on the patient's right of selfdetermination. This self-decision information was subject of the panel discussion. Not discussed in detail were the information concerning diagnosis and prognosis, and the instruction of the patient regarding his conduct postoperatively and during medical treatment. Not considered was the so-called malpractice and negligence respectively. Medical liability suits are increasing for various reasons and are frequently directed at a failure to inform the patient because the patient is often unable to prove a negligence of the physician ("surrogate liability"). The dimension of the duty of disclosure (complete information--no information at all) is discussed in general and with special regard to the radiological field.

Germany, West↗
PubMed1975

[How effective are tests for avoiding contrast reactions].

The frequency of known severe and fatal reactions after intravenous injections of biligrafin forte were compared during two periods. During the first period test ampules were provided; during the second period, the test ampules were no longer made. It was shown that the failure to perform tests did not result in any increase in the complication rate when compared with the period when test ampules were available. The problems arising from this comparison are discussed.

Biliary Tract Diseases↗