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D Scholer

Publications and source records attributed to D Scholer.

11 recordsLinked to original sources
PubMed1999

[Transition of molecular medicine from research to practice: tasks of the Swiss Academy of Medical Sciences (SAMW)].

During the symposium discussions were held in workshops on how the SAMS can support the transition of "molecular medicine" from research into practice. This transition is currently happening in prenatal diagnostics. With the help of molecular medicine doctors are at an early stage able to diagnose a variety of diseases, preliminary stages and dispositions of diseases--even with the unborn. Gene-diagnostics stands as a promising method of investigation, with no therapeutic equivalent yet. Here the SAMS should as soon as possible develop guidelines for the responsible use of gene-diagnostic methods; besides, the Academy should work towards connecting the use of gene-diagnostic methods to certain professional requirements. Furthermore, the SAMS is expected to ensure good basic and further training in the field of "molecular medicine" and to support "evidence-based medicine".

Evidence-Based Medicine↗
PubMed1975

Role of luminal hydrostatic pressure in proximal tubular fluid reabsorption in the rat.

The effect of small changes in intraluminal hydrostatic pressure (P) on the tubular radius (r) and the net fluid reabsorption per unit of surface area of the tubular wall (Js) has been studied in the proximal tubule of the rat kidney. The split-drop method was used to simultaneously determine Js and r. Two standardized split-drop techniques A and B allow selective change in P. P was 31.6 +/- 1.3 mmHg in technique A and 15.5 +/- 1.5 in technique B. The pressure difference significantly affected the tubular radius; r was 21.9 +/- 0.4 and 18.6 +/- 0.5 mum in the split drop A and B, respectively. In contrast, net transepithelial fluid reabsorption Js was unchanged. Js amounted to 2.72 +/- 0.20, and 2.78 +/- 0.33 10(-5) cm3 cm-2 s-1 in split drop A and B. The absence of variations in Js could result from two opposite effects of pressure. P might enhance Js by increased ultrafiltration. However, the rise in r might decrease the density of the intraepithelial transport paths per unit area of tubular wall and therefore might decrease Js.

Absorption↗