Biomedical subjects
Publications and source records attributed to D Sedgwick.
Managers in Doncaster health district were concerned to ensure community practice teachers give a high quality standard of teaching to students. June Evans and Dorothy Sedgwick describe the process of introducing audit to the community practice teaching of health visitor and district nurse students.
This paper reports the pathological features of a diaphragmatic haemangiopericytoma with a discussion of diagnostic difficulties it may present in relation to other localised mesenchymal tumours of the pleura. The published reports of diaphragmatic haemangiopericytoma in the world english language literature are reviewed.
Ceramic and non-ceramic forms of uranium dioxide, produced industrially, were administered to rats either by inhalation or as an aqueous suspension which was injected directly into the pulmonary region of the lungs. The results showed that: 1 both materials should be assigned to inhalation class Y as defined by the International Commission on Radiological Protection; 2 whilst the translocation of uranium to the blood for the non-ceramic UO2 was about twice that obtained for the ceramic form, the two dioxides were unlikely to be differentiated on the basis of their lung retention kinetics; 3 the distribution of uranium amongst body tissues and the relationship between systemic content and cumulative urinary excretion indicated that it was transported in the hexavalent form; 4 in addition to air sampling procedures, lung radioactivity counting measurements could be used to advantage for assessing occupational exposures; 5 the exposure limits should be based on radiation dose rather than chemical toxicity.
Aerosols produced from two commercially available ore concentrates in which the uranium was present essentially in the one as ammonium diuranate (ADU) and in the other as uranium octoxide (U3O8) were administered to rats. The results show that: 1 uranium in the ADU bearing material was cleared rapidly from the lungs, mainly to the blood, such that the retention kinetics were similar to those for a class D (highly transportable) compound as defined by ICRP; 2 uranium in the U3O8 bearing material was removed from the lungs principally by mechanical processes, the retention kinetics in this case being similar to those defined for a class Y (poorly transportable) compound; 3 for both materials the distribution of uranium amongst body tissues and the fraction of the systemic content excreted in urine were similar to those obtained after the injection of soluble hexavalent compounds; 4 for workers potentially exposed to both these materials, urine monitoring and lung radioactivity counting measurements should be used in addition to air sampling procedures for assessing the intake of uranium. 5 intakes of the ADU bearing material should be restricted to those permitted for short-term exposures on the basis of chemical toxicity, whereas those for the U3O8 bearing material should be governed by radiation dose.
UNLABELLED: Two commercially produced natural uranium tetrafluorides were administered to rats either by inhalation or direct injection into the lungs. THE RESULTS: show that, for both materials uranium is cleared rapidly from the lungs, much of it to the blood, show that the distribution of uranium amongst body tissues, and the fraction of the systemic content excreted in urine, is similar to that obtained after the administration of U(VI) bicarbonate, show that the transportability of uranium is much greater than in previously reported studies with other preparations of uranium tetrafluoride, suggest that lung radioactivity counting measurements would be of limited value for interpreting human exposures, indicate that for setting exposure limits these tetrafluorides should be considered moderately transportable compounds (ICRP inhalation class W).
UNLABELLED: Uranium trioxide, produced industrially, was administered to rats either by inhalation or direct injection of an aqueous suspension into the lungs. THE RESULTS: show that uranium was cleared rapidly from the lungs, mainly to the blood; show that distribution of uranium among body tissues, and the fraction of the systemic content excreted in urine, was similar to that obtained for other transportable hexavalent uranium compounds; suggest that urine monitoring data would be of more value than lung radioactivity counting measurements for assessing occupational human exposure; indicate that for setting exposure limits by inhalation the uranium trioxide should be considered a highly transportable compound. Thus intakes by workers should be restricted to those recommended for short-term exposures and not those based on an annual limit.
Explore the source record for details and available documents.
Explore the source record for details and available documents.