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Biomedical subjects

D Seligson

Publications and source records attributed to D Seligson.

At least 55 records · Page 3Linked to original sources
PubMed1995

Tibial pilon fractures: a comparative clinical study of management techniques and results.

Thirty-eight consecutive pilon fractures were reviewed retrospectively to compare the radiographic and clinical results with the original injuries based on three different treatment options: external fixation only, external fixation with limited internal fixation, and internal fixation only. Dates of injury were from February 1985 to February 1989. Treatment method was the surgeon's preference. The mean follow-up time was 28 months. Results were tabulated by clinical and radiographic scores. In general, simple fracture types had good results; complex ones did less well. In this study, fracture severity appeared to be the key variable in outcome.

Adolescent↗
PubMed1995

Traditional versus alternative olecranon osteotomy. Historical review and biomechanical analysis of several techniques.

Olecranon osteotomy for visualization of the distal humerus has a high complication rate. Two basic osteotomies, intra-articular and extra-articular, are in current use. Each is examined using the engineering technique of free-body analysis. The osteotomy fragment mechanics are found to influence both the nature of the fixation and the clinical outcome. In addition to the advantages gained from not disrupting the joint surface, oblique extra-articular osteotomy may have mechanical advantages over transverse intra-articular osteotomy because of decreased osteotomy surface distraction force with triceps contraction.

Biomechanical Phenomena↗
PubMed1995

Local antibiotic therapy for severe open fractures. A review of 1085 consecutive cases.

We reviewed 1085 consecutive compound limb fractures treated in 914 patients at the University of Louisville over a nine-year period. Of these fractures, 240 (group 1) received only systemic antibiotic prophylaxis and 845 (group 2) were managed by the supplementary local use of aminoglycoside-polymethylmethacrylate (PMMA) beads. There were no significant differences in age, gender, fracture type, fracture location or follow-up between the two groups. All had copious wound irrigation, meticulous debridement and skeletal stabilisation, but wound management and the use of local antibiotic depended on the surgeon's individual preference and there was no randomisation. In group 1 there was an overall infection rate of 12% as against 3.7% in group 2 (p < 0.001). Both acute infection and local osteomyelitis showed a decreased incidence in group 2, but this was statistically significant only in Gustilo type-IIIB and type-IIIC fractures for acute infection, and only in type-II and type-IIIB fractures for chronic osteomyelitis. Our review suggests that the adjuvant use of local antibiotic-laden PMMA beads may reduce the incidence of infection in severe compound fractures.

Adolescent↗
PubMed1994

[Optimal timing of wound closure in severe open fractures with temporary coverage by skin substitute].

In a consecutive series of 1085 open fractures treated at the University of Louisville Level I Trauma Center from May 1983 to July 1992, 381 severe compound fractures in 335 patients were managed with the antibiotic bead pouch technique. There were 27 grade I (marked swelling, compartment syndrome), 115 grade II and 239 grade III open fractures (94 type IIIA, 114 type IIIB and 31 type IIIC). These fractures were managed with early administration of broad spectrum antibiotics, copious wound irrigation, serial debridements and external skeletal stabilization. Tobramycin-PMMA-beads were placed in the wound and porous plastic film (Opsite) covered the soft tissue defect. This dressing was changed every 48 to 72 hours until wound coverage/closure could be obtained. Infection rate either on an acute or chronic basis was 2.6% in grade II open fractures and 8.4% in grade III compound fractures. There was no infected wound or bone in the grade I category. Those fractures which did not develop an infection were closed at a mean time of 7.6 days; those which developed an infection were closed at a mean time of 17.9 days. The difference was statistically highly significant (p < 0.001). When severe open fractures are managed with the antibiotic bead pouch technique, wound closure should be obtained within one week to prevent infectious complications.

Adolescent↗
PubMed1994

The management of open fractures associated with arterial injury requiring vascular repair.

Seventy-two open fractures associated with arterial injury requiring vascular repair (Gustilo type IIIC injuries) were treated at the University of Louisville from May 1983 and through 1992. The involved anatomic areas were the humerus (four), forearm (ten), femur (eight), tibia (31), ankle (ten), and foot (nine). Fracture management consisted of careful débridement, wound irrigation, fasciotomy, and fracture stabilization. Additionally, 40 wounds (55.6%) were treated with the supplemental use of local antibiotics (tobramycin-PMMA bead chains). Twenty-three patients (32.1%) underwent primary amputation, and 49 (67.99%) of the injured vessels were repaired. There were seven secondary amputations because of infection or poor revascularization, resulting in an overall amputation rate of 41.6%. The wound infection rate was 13.9% (10 of 72) and the rate for osteomyelitis was 4.2% (3 of 72). The local use of the antibiotic bead chains was of significant benefit in lowering infectious complications. Primary coverage of soft-tissue defects with free tissue transfer had an infection rate of 66%; temporary wound coverage with the "antibiotic bead pouch" technique until wound closure can be obtained in a sterile and viable environment appears to be a better option.

Adolescent↗
PubMed1994

Prolonged warm ischemia and limb survival: case report.

A 21-year-old woman sustained a supracondylar crush injury of her arm. The extremity underwent severe ischemia for more than 16 hours after an unsuccessful brachial artery repair. The forearm muscles became rigid and the fingers could not be extended passively. Clinically these findings were felt to be similar to rigor mortis. Despite this dismal picture, secondary revascularization resulted in a highly functional hand with no loss of digits. Desperate attempts at revascularization in isolated extremity injury may be successful, despite prolonged warm ischemia time.

Adult↗
PubMed1994

Timing of wound closure in severe compound fractures.

In a consecutive series of 1085 open fractures treated from May 1983 to July 1992, 381 severe compound fractures in 335 patients were managed with the antibiotic bead pouch technique. There were 27 grade I (marked swelling, compartment syndrome), 115 grade II, and 239 grade III open fractures (94 type IIIA, 114 type IIIB, and 31 type IIIC). These fractures were managed with early administration of broad spectrum antibiotics, copious wound irrigation, serial debridements, and external skeletal stabilization. Tobramycin-PMMA beads were placed in the wound, and porous plastic film (Opsite, Smith and Nephew Medical, Limited, Hall, England) covered the soft tissue defect. This dressing was changed every 48 to 72 hours until wound coverage/closure could be obtained. Infection rate, either on an acute or chronic basis, was 2.6% in grade II open fractures and 8.4% in grade III compound fractures. There was no infected wound or bone in the grade I category. Those fractures that did not develop an infection were closed at a mean time of 7.6 days; those that developed an infection were closed at a mean time of 17.9 days. The difference was statistically significant (P < 0.001). When severe open fractures are managed with the antibiotic bead pouch technique, wound closure should be obtained within 1 week to prevent infectious complications.

Adolescent↗
PubMed1994

Pin tract infections: silver vs uncoated pins.

To test the hypothesis that coating external fixation pins with a silver-containing compound (Spi-Argent, Spire Corp, Bedford, Mass) will reduce bacterial colonization and/or pin tract infection, 36 silver-coated and 12 conventional stainless steel pins were placed in the iliac crest of six sheep and inoculated with Staphylococcus aureus. After 2 1/2 weeks the pin sites were examined for motion and inflammation, and the pin tips were quantitatively cultured and examined with scanning electron microscopy (SEM). We found that 84% of the uncoated pins were infected, while 62% of the silver-coated pins were infected. Silver-coated pins were less frequently infected than uncoated pins (confidence interval [CI] > 85%). Also, silver-coated pins were loose less frequently than uncoated pins. Pin motion was closely correlated with infection: 28 of 32 infected pins (88%) had motion, while only 9 of 16 uninfected pins (56%) had motion (CI > 80%). SEM study of the pin tips showed a decreased level of glycocalyx-protected colonization on the surface of the silver-coated pins. Clinically, these results suggest that silver-coated pins will result in less infection and motion at the pin site, the most significant problems in external fixation.

Animals↗
PubMed1994

[The development of external osteosynthesis before World War II].

External fixation undoubtedly represents a great contribution to treatment of fractures. Its development goes back to middle of 19th century and is connected with the name of Joseph Francois Malgaigne, even though this outstanding doctor was probably not the first one to have used it. It is difficult to determine exactly the sequence of individual authors according to their merit, because each of them contributed to the development of external fixation in a different way. Nevertheless there are a few names that deserve special attention as Lambotte, Parkhill, Putti, H. Judet and Klapp with Block, who made significant steps forward in the development. It is obvious that external fixateurs in the time before World War Two were already highly developed devices and in comparison with the present situation in the field we could say that almost everything has been here before, only the precision of manufacturing of components and quality of used materials are on a higher level.

External Fixators↗
PubMed1993

[Value of adjuvant local antibiotic administration in therapy of open fractures. A comparative analysis of 704 consecutive cases].

Seven hundred and four compound fractures--198 (28%) grade I, 259 (37%) grade II, 247 (35%) grade III (86 IIIA, 119 IIIB, 42 IIIC)--were treated in 590 patients between May 1983 and May 1989 at the University of Louisville. Of these fractures, 157 (22%, group 1) received systemic antibiotic prophylaxis only, whereas 547 (78%, group 2) were treated with additional local application of aminoglycoside beads (tobramycin). Comparison of factors (fracture grades, age, sex, fracture location, follow up) revealed no significant differences between the two groups. All fractures underwent timely irrigation, debridement and skeletal stabilization. In group 1, 52 wounds were primarily closed, 53 underwent delayed primary closure and 52 were left open. In group 2 283 wounds were primarily closed, 229 were managed with the bead pouch technique and 35 were adapted loosely (delayed closure). Forty-nine (6.96%) of the 704 compound fractures became infected (acute wound infection and/or chronic osteomyelitis). Group 1 showed an infection rate of 16.6% (26/157), group 2 a rate of 4.2% (23/547). The difference was statistically highly significant (P < 0.001). Comparison of the infection rates, whether on an acute or a chronic basis, showed that infection rates were lower in group 2 than in group 1 for all fracture grades. A statistically significant difference was established only for type IIIB fractures, where the wound infection rate was 39.1% (9/23) in group 1 and 7.3% (7/96) in group 2 (P < 0.001). The rate of chronic osteomyelitis was 26.1% (6/23) in group 1 and 6.3% (6/96) in group 2 (P < 0.025).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1993

Antibiotic-leaching from polymethylmethacrylate beads.

Aminoglycoside-impregnated polymethylmethacrylate beads, which are used to deliver antibiotic directly to infected sites in the musculoskeletal system, are available as a manufactured product or they can be mold-made by a pharmacy or hand-rolled by the orthopaedist in the operating suite. We investigated the leaching of antibiotic from each of these types of beads. Our hypothesis was that the elutions of antibiotic from the three types of beads are similar. Three study groups (hand-made, mold-made, and manufactured beads), each composed of four five-bead subsets, were formed so that twenty beads of each type were tested. Each bead was leached daily in a two-milliliter aliquot of normal saline solution throughout a sixty-day period, and the aminoglycoside concentration in twenty of these aliquots was determined. Analysis of variance showed no statistically significant differences when the antibiotic elutions within each subset, between the different subsets, and between the three groups were compared. The clinically important finding of this investigation is that the leaching characteristics of the three types of aminoglycoside-impregnated beads are equivalent when the beads have been fabricated out of comparable materials.

Diffusion↗
PubMed1993

The intramedullary hip screw.

The intramedullary hip screw is a short intramedullary nail with interlocking screws that can be used to treat subtrochanteric and intertrochanteric femur fractures. This nail, which has the biomechanical advantage of being an intramedullary appliance but can be placed percutaneously, is inserted under fluoroscopic control with the patient on a fracture table. Reaming is not usually necessary. In an initial limited series, complication rates are comparable with existing techniques. Possible future concepts and developments are discussed.

Bone Nails↗
PubMed1993

Intramedullary supracondylar nailing of femoral fractures. A preliminary report of the GSH supracondylar nail.

From 1987 through 1990, 34 acute supracondylar femoral fractures in 33 patients were treated with an interlocking closed-section intramedullary nail inserted retrograde into the femur through the intercondylar notch. Follow-up data of at least five months were available for 25 of these fractures. The patients suffered injuries more extensive than comparable patients reported in the literature. All fractures healed clinically and radiographically. The average arc motion at the most recent evaluation was 100 degrees. The average operative time was 156 minutes and the average estimated blood loss was 224 ml. Complications related to this treatment were successfully resolved. The genucephalic nail is a good treatment for supracondylar femoral fractures.

Adolescent↗
PubMed1993

[Radiologic determination of bone screw exit site on the femoral condyle. A method of exact imaging and length determination of internal fixation devices (screws, K-wires) in metaphyses of larger tubular bones exemplified by the distal femur].

Distal femur imaging (A-P and lateral X-rays) after internal fixation often give only poor visualization of the exact position. A model with two anteriorly positioned cortex screws was used to show that an additional oblique X-ray, or fluoroscopy of the tip of the screw, allows much more exact determination of its length, so that it can be changed if necessary. This method is considered by the authors as a simple check of screw length measurement in "foyer fermée" procedures.

Adolescent↗
PubMed1993

Dudley and Griswold: the development of fracture treatment in Kentucky.

The surgical record of the great state of Kentucky is impressive and one to be admired. Two Kentucky physicians helped pave the way to the modern treatment of fractures. Doctors Benjamin Dudley and R. Arnold Griswold contributed unique ideas and opinions to the practice of orthopaedic surgery. Their techniques and practices were ahead of their times, and today we see a little of each in our everyday treatment of fractures.

Fracture Fixation↗
PubMed1993

Secondary intramedullary nailing of complicated fractures of lower extremities.

Between 1984 and 1991, 16 patients with 23 fractures of the lower extremities were treated with external skeletal fixation and subsequent intramedullary nailing. There were 7 closed fractures, 1 closed fracture with vascular injury, 2 Grade I, 3 Grade II and 10 Grade III injuries, sansistiny of 5 Grade IIIA, 2 Grade IIIB and 3 Grade IIIC fractures. The fractures were maintained in external fixation for an average of 14 days (range 4 to 32 days) after which the fixateur was removed and an intramedullary nail placed during the same procedure in all cases. Two of the twenty-three fractures, 9%, subsequently developed deep infections involving the intramedullary canal, both of which resolved with antibiotics while retaining the nail. Thus we were able to place intramedullary fixation in these difficult and often contaminated injuries in less than one month with a relatively low incidence of complications.

Adolescent↗
PubMed1993

The role of local antibiotic therapy in the management of compound fractures.

Seven hundred four compound fractures (198 [28%] Grade I, 259 [37%] Grade II, and 247 [35%] Grade III) were treated during a seven-year period at the author's institution. One hundred fifty-seven open fractures (22%) (Group A) received systemic antibiotic prophylaxis only, whereas 547 compound fractures (78%) (Group B) were treated with local application of antibiotic beads (tobramycin) in addition to prophylaxis. Fracture grades, age, gender, fracture location, and length of follow-up period were not significantly different between the two groups. All fractures underwent timely irrigation, debridement, and skeletal stabilization. Forty-nine of 704 compound fractures (7%) developed an infection (acute wound infection or chronic osteomyelitis or both). Group A showed an infection rate of 17% (26/157); treatment in Group B resulted in 23 compound fracture infections (4.2%). The difference in the incidence of infection was statistically significant. Comparison of the infection rates in either wound infection or chronic osteomyelitis showed a trend toward decreased rates in Group B versus Group A throughout all fracture grades. However, by subdivision into the fracture grades, only the IIIB types had a statistically significant decrease of infection in Group B versus Group A; the wound infection rate was 39% (9/23) in Group A and 7.3% (7/96) in Group B. The rate of chronic osteomyelitis was 26% (6/23) in Group A and 6.3% (6/96) in Group B. Prophylactic use of antibiotic-laden PMMA beads in addition to systemic antibiotics was of benefit in preventing infectious complications in compound fractures, in particular in Type IIIB open fractures.

Acute Disease↗