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Biomedical subjects

D Sherr

Publications and source records attributed to D Sherr.

6 recordsLinked to original sources
PubMed1996

Malignant lymphoma involving the patella.

The majority of skeletal lesions affecting the patella are benign and include entities such as chondroblastoma, giant cell tumor, osteomyelitis, and gout. Malignant processes involving the patella are distinctly unusual. Isolated occurrences of plasmacytoma, osteosarcoma, hemangiosarcoma, and metastatic disease have been reported. Malignant lymphoma involving the patella is extremely uncommon, although lymphomatous infiltration of the skeletal system is not a rare event, especially with the histiocytic lymphoma. The most frequent radiologic manifestations of skeletal lymphoma include osteolytic lesions with ill-defined margins involving the metaphysis of the long bones of the lower extremities. Involvement of the short tubular and flat bones, as well as the axial skeleton, occurs less commonly. The prognosis for lymphoma involving the skeleton is poor.

Aged↗
PubMed1996

Radiation therapy for subretinal neovascularization.

PURPOSE: To evaluate low-dose external beam irradiation and plaque radiotherapy for the treatment of subretinal neovascularization. METHODS: The authors treated 137 patients with radiation therapy for subretinal neovascularization. Herein, they examine a subset of 75 patients with exudative age-related macular degeneration who were treated with (4- or 6-MV photons) external beam irradiation at a dose of 1200 to 1500 cGy to the affected macula. In addition, six patients were treated with palladium 103 ophthalmic plaque brachytherapy to an equivalent retinal apex dose of 1200 to 1500 cGy. The authors compared the intralesional, intraocular, and intracranial radiation dose distributions of each treatment modality. Early Treatment Diabetic Retinopathy Study-type visual acuity determinations, ophthalmic examinations, and angiography were performed before and after treatment. Clinical evaluations were performed in a nonrandomized and unmasked fashion. RESULTS: Episcleral plaque brachytherapy was found to provide a higher average radiation dose within the neovascular tissues while delivering less radiation to most normal ocular (both eyes) and all intracranial structures. Both forms of radiotherapy were associated with decreased hemorrhages, exudates, and leakage of neovascular membranes. Ten (13 percent) patients receiving external beam radiotherapy had transient epiphora and ocular irritation. CONCLUSION: Observation and laser photocoagulation of subfoveal neovascularization have been associated with poor visual outcomes. Pilot experience suggests that low-dose radiotherapy offers a method to treat subretinal neovascularization without destroying the overlying retina. Although the authors' radiation distribution studies favored plaque radiotherapy, additional factors such as relative efficacy, expense, convenience, and safety must be investigated.

Aged↗
PubMedDate not supplied

Differences in histology between first and second primary lung cancer.

Data from the Surveillance, Epidemiology, and End Results (SEER) Program were used to compare the histological distribution of second lung cancer following an initial cancer of the lung, head and neck, and breast to primary lung carcinoma occurring as a first cancer. Following initial head and neck cancer or initial squamous cell carcinoma of the lung, the proportion of second primary lung cancer which was of squamous cell histology rose dramatically, while the proportion of pulmonary adenocarcinomas rose following initial adenocarcinoma of the lung. The histological distribution of lung cancer following an initial breast cancer in women was similar to the distribution of de novo lung cancer in women. These results persisted as the time interval between diagnosis of the two primaries was increased from 12 to 48 months. We conclude that the histology of a second primary lung cancer following an initial cancer of the lung or head and neck tends to repeat the histology of the initial cancer (field effect), and this observation is not likely to be due to misdiagnosis of a recurrence of the initial cancer.

Adenocarcinoma↗
PubMedDate not supplied

Variations in energy and phospholipid metabolism in normal and cancer human mammary epithelial cells.

By comparing the metabolism of human mammary epithelial cells and human breast cancer cells (MCF7 and T47D), proliferating at approximately the same rate, it was possible to isolate the effect of malignancy alone on the energetics and phospholipid metabolism of cancer cells. 31p NMR of perfused mammary cells and of water soluble extracts of these cells showed that the levels of phosphocholine, phosphoethanolamine, and glycerol derivatives of these metabolites were very low and significantly less than that in the cancer cells, suggesting an association of malignancy with induction of phospholipid biosynthesis and breakdown. The level of the high energy phosphates and the rates of glucose consumption and aerobic glycolysis did not reveal distinct differences between normal and cancer cells. The comparable energetic appear to be related to the similarity of proliferating capacity in culture of the normal and cancer cells.

Breast↗