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D Sherrington

Publications and source records attributed to D Sherrington.

At least 19 recordsLinked to original sources
PubMed2001

Dynamics of the batch minority game with inhomogeneous decision noise.

We study the dynamics of a version of the batch minority game, with random external information and with different types of inhomogeneous decision noise (additive and multiplicative), using generating functional techniques à la De Dominicis. The control parameters in this model are the ratio alpha=p/N of the number p of possible values for the external information over the number N of trading agents, and the statistical properties of the agents' decision noise parameters. The presence of decision noise is found to have the general effect of damping macroscopic oscillations, which explains why in certain parameter regions it can effectively reduce the market volatility, as observed in earlier studies. In the limit N-->infinity we (i) solve the first few time steps of the dynamics (for any alpha), (ii) calculate the location alpha(c) of the phase transition (signaling the onset of anomalous response), and (iii) solve the statics for alpha>alpha(c). We find that alpha(c) is not sensitive to additive decision noise, but we arrive at nontrivial phase diagrams in the case of multiplicative noise. Our theoretical results find excellent confirmation in numerical simulations.

Journal Article↗
PubMed2001

Evaluation of methods aimed at complete removal of template from molecularly imprinted polymers.

Polymers imprinted with clenbuterol were used to study the influence of various post-polymerization treatments [e.g., thermal annealing, microwave assisted extraction (MAE), Soxhlet extraction and supercritical fluid template desorption] on the bleeding of residual template. The aim of the study was to reduce the bleeding to levels that would allow the use of the materials as affinity phases for extraction of clenbuterol from bovine urine at concentrations below 1 ng ml-1. After treatment, the clenbuterol imprinted polymers were packed into solid-phase extraction columns and the bleeding was estimated by quantifying the amount of template released in 10 ml of methanol-acetic acid (9 + 1 v/v). This was followed by an assessment of selectivity and recovery in comparison with non-treated material. The lowest bleeding level was found after MAE using 100% trifluoroacetic acid for 3 x 20 min at 100 degrees C. The collected eluate contained in this case 3 ng ml-1 of clenbuterol. The same material was subsequently used for the extraction of clenbuterol from spiked bovine urine. The resulting selectivity and recovery were lower compared with those obtained using the untreated material. A milder but still efficient method to reduce the bleeding level was found to be MAE with formic acid. In this case a bleeding level of 14 ng ml-1 was found after only a 1 h extraction time. In a second model system, using a polymer imprinted with L-phenylalanine anilide, the bleeding was reduced to a similar level by extensive on-line washing in good swelling solvents containing acid or base additives and after thermal annealing of the polymers in the dry state.

Journal Article↗
PubMed2000

Application of molecularly imprinted polymers in supercritical fluid chromatography.

Molecularly imprinted polymers (MIPs), for the templates free base racemic propranolol and the L-enantiomer of phenylalanine anilide (L-PA), were investigated as stationary phases in supercritical fluid chromatography (SFC). Large retention differences were observed on the propranolol MIP for both the template molecule and the structural analogue metoprolol compared to that observed on the corresponding blank polymer. Mobile phase composition and solute concentration were found to affect this retention behaviour. The phenylalanine anilide MIP (L-PA MIP) was found to be enantioselective in SFC with stronger retention observed for the template enantiomer. Throughout the study, characteristic imprinting peak shapes for the stronger retained template molecule were observed for both MIPs examined. After a number of days under supercritical fluid conditions, the performance of the photochemically initiated L-PA MIP was found to significantly deteriorate whereas the thermally initiated propranolol MIP revealed only small changes in its separation performance after a long term of operation. The separation behaviour of these two MIPs in SFC was compared with results obtained on the same columns in high-performance liquid chromatography (HPLC) both before and after their application in SFC.

Chromatography↗
PubMed2000

Use of molecularly imprinted solid-phase extraction for the selective clean-up of clenbuterol from calf urine.

A feasibility study was performed in order to study the possibilities in using molecularly imprinted polymers (MIPs) as sorbent material in solid-phase extraction (MISPE) for clean-up of clenbuterol from urine. A binding study of clenbuterol in several solvents was performed on a clenbuterol imprinted polymer as well as on a blank polymer. These binding experiments were used to find suitable loading, washing and elution solvents for the MISPE procedure. Extraction of clenbuterol from calf urine was performed by directly loading a 10-ml urine sample onto the MIP column. Thereafter the column was washed with 10 ml of acetonitrile containing 1% acetic acid, and finally clenbuterol was eluted with 6 ml of methanol containing 10% acetic acid. A recovery of 65% was obtained. This recovery could be increased up to 75% if a sample volume of 1 ml was used or up to 100% if urine was freeze-dried and the residue was dissolved in acetonitrile and spiked with clenbuterol prior to analysis. Chromatograms of the wash and eluate solutions show an efficient clean-up, which supports the potential of MISPE for clean-up of trace amounts of clenbuterol from calf urine.

Adrenergic beta-Agonists↗
PubMed2000

Continuous time dynamics of the thermal minority game

We study the continuous time dynamics of the thermal minority game. We find that the dynamical equations of the model reduce to a set of stochastic differential equations for an interacting disordered system with nontrivial random diffusion. This is the simplest microscopic description which accounts for all the features of the system. Within this framework, we study the phase structure of the model and find that its macroscopic properties strongly depend on the initial conditions.

Journal Article↗
PubMed1999

Competition between glassiness and order in a multispin glass.

A mean-field multispin interaction spin glass model is analyzed in the presence of a ferromagnetic coupling. The static and dynamical phase diagrams contain four phases (paramagnet, spin glass, ordinary ferromagnet, and glassy ferromagnet) and exhibit reentrant behavior. The glassy ferromagnet phase has anomalous dynamical properties. The results are consistent with a nonequilibrium thermodynamics that has been proposed for glasses.

Journal Article↗
PubMed1993

Fast learning of biased patterns in neural networks.

Usual neural network gradient descent training algorithms require training times of the same order as the number of neurons N if the patterns are biased. In this paper, modified algorithms are presented which require training times equal to those in unbiased cases which are of order 1. Exact convergence proofs are given. Gain parameters which produce minimal learning times in large networks are computed by replica methods. It is demonstrated how these modified algorithms are applied in order to produce four types of solutions to the learning problem: 1. A solution with all internal fields equal to the desired output, 2. The Adaline (or pseudo-inverse) solution, 3. The perceptron of optimal stability without threshold and 4. The perceptron of optimal stability with threshold.

Algorithms↗