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Biomedical subjects

D Shinkov

Publications and source records attributed to D Shinkov.

12 recordsLinked to original sources
PubMed1989

[Immune hemolytic anemia caused by catergen].

A case is presented of a man with chronic active hepatitis who developed immune hemolytic anemia in the course of a prolonged treatment with Catergen/(+)-Cianidanol-3/Zyma (four therapeutic courses in two years). The possible mechanism of hemolysis during Catergen treatment are discussed. The most probable mechanism is the absorption of the drug on the erythrocytes. The Catergen fixation on the erythrocytes does not require any special structure connected with the blood group antigens. Probably the link is non-covalent since the drug is easily removed from the erythrocytes--for 10 min at 56 degrees C.

Acute Disease↗
PubMed1981

[Biphasic peroxidase in the study of Fc receptors of leukemic lymphocytes].

The authors examined Fc receptors of cytoplasmic membrane by means of a two-stage immunoperoxidase technique: at the first stage the immuno-gamma-globulins (IgG), labelled with peroxidase, were connected with the membrane receptors, but at the second stage the connection was stabilised by supplementation of homologous antigen. In healthy persons (20 volunteers) the percentage of lymphocytes, which carried membrane Fc receptors for IgG, were in the ranges of 25% and 42%. In leukemic lymphocytes, verified as B population by immunofluorescent technique, they found that over 95% of these lymphocytes carried membrane receptors for Fc of IgG (examined in 10 persons with chronic lympholeucosis). It could be concluded that the leukemic process does not involve Fc receptor structures in contrast to immunoglobulin receptors, which in these cases are altered considerably, having in mind the amount of the connected labelled IgG and the way od its location on the cytoplasmic membrane.

B-Lymphocytes↗
PubMed1979

[Immunohematological problems in blood transfusion with patients with autoimmune hemolytic anemia].

The immunologic problems of blood transfusion of patients with antoimmune hemolytic anemia are discussed on the base of the authors' observations. They emerge and are mainly conditioned by the character and serological characteristic of autoantibodies (AAB) as well as by the presence of free iso-antibodies (erythro-, leuko- and thrombocyte-). The cold AAB conditioned the difficulties in blood groups determination, direct compatibility test and rarely of RH, where as the warm ones -- impede the determination of Rh and the selection of compatible blood for transfusion. The emerging of iso-antibodied complicates further the immunologic status of the patients. Owing to the characteristic specificity of AAB (against the widely found antigens -- nl, w, I, Pr, etc), the finding of compatible blood for transfusion proved practically to be extremely difficult. The forces hemotransfusion to be turned to only in case of vital indications.

Agglutinins↗
PubMed1978

[Ultrastructural studies of the plasma cells in multiple myeloma].

Electron microscopic investigations of 38 patients with multiple plasmocytoma were carried out, the patients being divided into three groups according to the type of monoclonic immunoglobin in serum or urine. Light to moderate cellular-cytoplasmatic asynchronism was found as well as hypertrophic nucleoli and versatile changes in cytoplasmatic organelles of the poliferous plasmocytes. Cellular-cytoplasmatic asynchronism is discussed as a characteristic sign of neoplastic plasmatic cells. No correlation was found between the morphological changes in the nuclei and cytoplasma and the immunoglobin class, secreted from the cells.

Bone Marrow↗
PubMed1978

[Clinical and laboratory aspects of multiple plasmacytoma].

Clinical-laboratory observations were carried out on 40 patients with multiple plasmocytoma. Morbidity maximum was established to be during the fifth and sixth decade of life and that males are more frequently affected and bone manifestations are dominating initial symptoms. The anemic syndrome, the renal syndrome, erythrocyte sedimentation reaction and the data of the differential leukocyte count are discussed in details. Special attention is paid to the pathognomonic examinations in making the diagnosis: myelogram, electrophoresis and immunoelectrophoresis and bone roentgenography. The absence of changes in one of those examinations is concluded not to exclude the diagnosis multiple plasmocytoma as it is found in 10--20 per cent of the cases.

Adult↗