Biomedical subjects

D Siravo

Publications and source records attributed to D Siravo.

3 recordsLinked to original sources

PubMed1989

[A pharmacological and clinical review on the activity of a bovine factor VIII derivative obtained by enzymatic hydrolysis].

We report pharmacological, experimental and clinical data of the new drug which decreases bleeding time but is devoid of procoagulant and platelet aggregating properties. The drug, derived from bovine factor VIII by enzymatic hydrolysis, did not show toxicological and immunological effects either in animals or in patients. In addition we report the review of the clinical studies in different pathological situations i.e. ophthalmology, odontostomatology, gynecology etc.

Adult↗

PubMed1989

Decrease of diffusion of glycosylated albumin in retinal microcirculation by peptide fraction from bovine factor VIII.

The diffusion of the glycosylated albumin in the retinal vascular system has been studied in male New Zealand rabbits, using fluorangiographic techniques. A first group of animals was treated for 15 days with the peptide fraction from bovine Factor VIII (Vueffe); a second group, used as control group, was treated with physiological solution. At the end of treatment, glycosylated albumin was made fluorescent and then injected into the marginal vein of the rabbit. The direct observation and the photometric measurements performed on the digitized photograms with an image processing system showed a considerable reduction in retinic capillary diffusion of glycosylated albumin in the animals treated with the peptide fraction. The substance used in the study might therefore be of importance in the treatment of systemic disease with retinic vascular damage.

Angiography↗

PubMed1988

Polypeptide fraction from bovine factor VIII used in fluorangiography.

We report a new method of fluorangiography employing a polypeptide fraction from bovine factor VIII that has shown remarkable affinity to the endothelial surface of microvessels. Rabbits injected with this compound, labeled with fluorescein isothiocyanate, show a very delayed disappearance time of fluorescence in retinal vessels when compared with those injected with ordinary fluorescein. This allows a good observation of the late time, which is of great diagnostic advantage for several pathological conditions.

Animals↗