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Biomedical subjects

D Snow

Publications and source records attributed to D Snow.

At least 19 recordsLinked to original sources
PubMed2000

The emotional basis of linguistic and nonlinguistic intonation: implications for hemispheric specialization.

Clinical and experimental studies suggest that the right cerebral hemisphere is dominant for intonation or the "melody of language." In light of this brain-behavior correlation, an assessment of intonation is a useful adjunct of the linguistic, cognitive, and neurological evaluation of patients with brain damage. However, the neural basis of intonation is controversial. This article examines 1 of the unresolved issues--the hypothesis that emotional versus linguistic categories of intonation are lateralized to the opposite hemispheres. A review of linguistic and neurobehavioral evidence fails to support the claim that intonation is divided into dichotomous categories. Linguistic analysis suggests that even intonation patterns traditionally described as nonemotional have their underpinnings in the speaker's emotions. Similarly, studies of adults and children with brain damage indicate that intonation patterns described as either linguistic or emotional are mediated by right-hemisphere substrate specialized for emotional experience. The cross-disciplinary findings support a general right-hemisphere hypothesis that unifies linguistic and emotional uses of intonation in children and adults. Implications of the hypothesis are discussed in relation to the diagnosis of developmental disorders, with special attention to the problem of identifying language impairment in infants and toddlers.

Adult↗
PubMed2000

Exploring the factors influencing relapse and recovery among drug and alcohol addicted women.

1. Both women who were in treatment for relapse to and in sustained recovery from drugs and alcohol had multiple co-occurring addictions such as relationship, spending, food, and shopping that complicated the recovery process. 2. Depression is a major trigger for relapse in women with alcohol and drug problems. Recognition and treatment of depression is critical to achieve successful outcomes of treatment for these women, and teaching them to monitor their mood changes and seek help will improve the chances of preventing relapse. 3. Subjects in neither the relapse nor recovery sample recognized the significant influence of current violent partnerships or the ending of a violent relationship on their relapse or recovery.

Adult↗
PubMed2000

Vietnam nursing: the experience lives on. Interview by Margaret Ann La Salle.

Through personal interviews and a review of the literature, this article examines the experiences of three nurses who served in the Vietnam conflict. Common themes emerging were the strength of the medical teams, the camaraderie, and the willingness of everyone to pitch in. Common coping strategies were turning to God for comfort and emotional support through peers.

Adaptation, Psychological↗
PubMed1999

Peribulbar innervation and substance P expression following nonpermanent injury to the human scalp hair follicle.

The hair pluck procedure alters the anatomy of the anagen hair bulb. Hemorrhage can occur in the mesenchymal sheath and breaks at the proximal epithelium, above or around the upper third of the dermal papilla, have been reported. We hypothesized that innervation, as identified with protein gene product 9.5 (PGP 9.5), and expression of the neuropeptide Substance P (SP) within the dermal papilla would also be altered following plucking. We focused on studying SP as this neuropeptide has been associated with several cellular responses, including anagen hair growth in the C57BL/6 mouse model. Four millimeter punch biopsies were obtained from the occipital scalp of two healthy adults. Hair was then plucked and additional biopsies were obtained immediately, and at 1 d, 1 wk, and 1 mo after plucking. Each set was processed for immunohistochemical analyses and in-focus optical sections of the dermal papilla were captured by laser scanning confocal microscopy and later reconstructed into single images. Following injury, SP was expressed in a disorganized pattern below the dermal papilla. There was also a significant reduction in labeled neuronal cells, and SP expression was enhanced within peribulbar blood vessels at 1 d and 1 wk. By 1 mo, peribulbar nerves, vessels, and SP expression were similar to baseline observations. It remains to be ascertained whether PGP 9.5, also known as unbiquitin hydrolase, and SP are involved in the proliferation of new matrix cells in the human scalp hair follicle following injury.

Adult↗
PubMed1998

Depressive symptom differences in hospitalized, medically ill, depressed psychiatric inpatients and nonmedical controls.

This study compared depressive and anxious symptoms in chronic medically ill individuals and depressed psychiatric inpatients using conceptually based standardized measures of cognitions and symptoms. Seventy-five hospitalized medical patients, 52 depressed psychiatric inpatients, and 25 normal controls were assessed with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; American Psychiatric Association, 1987), the Mood and Anxiety Symptom Questionnaire, Hamilton Rating Scales of Anxiety and Depression, Hospital Anxiety and Depression Scales, Beck Depression Inventory, Cognitions Checklist, and Hopelessness Scale. Analysis revealed that depression in medical patients was best distinguished by symptoms of anhedonia, low positive affect, and physiological hyperarousal, whereas syndromal depression in psychiatric inpatients was specifically characterized by negative cognition symptoms. Implications are discussed for assessing depression in medically ill populations.

Adolescent↗
PubMed1998

Children's imitations of intonation contours: are rising tones more difficult than falling tones?

Perceptual evidence suggests that young children do not imitate adult-modeled intonation patterns with a rising pitch contour (rising tones) as well as those with a falling pitch contour (falling tones). To investigate the acoustic basis of this uneven imitation pattern, 10 4-year-old children were asked to imitate short sentences with falling and rising tones in 4 sentence contexts called "intonation groups." The results indicated that the children used more falling tones than adults in most intonation groups. When the children matched the adult-modeled contour direction (falling or rising), the children's speed of pitch change was comparable to that of adults in the falling tones of final intonation groups and in the rising tones of nonfinal groups, but was slower than that of adults in the complementary environments. In a manner consistent with previously reported perceptual data, the instrumental findings indicate that rising tones may be more difficult for 4-year-old children to produce than falling tones. The results additionally suggest that children's intonation is sensitive not only to the direction of tonal contours but also to their position in sentence-final versus nonfinal intonation groups.

Child Behavior↗
PubMed1998

Prosodic markers of syntactic boundaries in the speech of 4-year-old children with normal and disordered language development.

This study focuses on the potential role of prosodic "boundary features" in developmental disorders of morphosyntax. As exemplified melodically by the final portion of the falling tone and rhythmically by final syllable lengthening, boundary features mark the right edge of major constituent units in speech and thus phonetically reflect syntactic structure on the level of clauses and sentences. To resolve conflicting findings about the development of boundary features in children with specific language impairment (SLI), this study describes the falling tone and final syllable lengthening in the spontaneous speech of 10 four-year-old children with the phonologic-syntactic type of SLI and 10 four-year-old children with normal language development. The results--indicating that some prosodic boundary features are normal in preschoolers with SLI--show that impairments of morphology and syntax on the segmental level of the grammar do not implicate systematic deficits in syntax-sensitive features on the suprasegmental level. The potential dissociation between prosodic and morphosyntactic development is shown most clearly by the remarkable robustness of the falling tone, which was observed in 9 of the 10 children with SLI, in spite of the moderate to severe deficits they demonstrated in segmental phonology, morphosyntax, and mean length of utterance.

Child, Preschool↗
PubMed1998

A prominence account of syllable reduction in early speech development: the child's prosodic phonology of tiger and giraffe.

When young children produce multiword utterances and words that are polysyllabic in adult speech, they are most likely to omit unstressed syllables. Because unstressed syllables are omitted more often in weak-strong (iambic) than in strong-weak (trochaic) environments, a trochaic metrical theory has been proposed to account for the asymmetrical omission pattern. This paper presents an alternative explanation based on the notion of relative prosodic prominence. I propose that syllable prominence is a product of two orthogonal suprasegmental systems: one that marks stress/accent peaks and one that marks phrase boundaries. A two-component scale of prominence values reflecting the contributions of both systems was used to analyze single- and multi-word speech samples of 11 children 19 to 26 months of age. The results show that the prominence scale parsimoniously accounts not only for the bias toward syllable omissions in nontrochaic environments but also explains other types of syllable reduction not captured by metrical theories. Implications of the dual-system prosodic model are discussed in terms of possible contributions to a perceptually based theory of early polysyllabic and multiword patterns in child speech.

Child Language↗
PubMed1997

Children's acquisition of speech timing in English: a comparative study of voice onset time and final syllable vowel lengthening.

This study describes English-speaking children's acquisition of voice onset time (VOT), a segmental feature that specifies the timing of word-initial stop consonants, and final-syllable vowel lengthening (FSVL), a suprasegmental feature that influences the timing of vowels. The purpose of this study was to evaluate two hypotheses about the acquisition of speech timing contrasts; a 'motoric' hypothesis predicting that children would control the vowel duration contrast earlier than the consonantal one (FSVL before VOT), and a 'representation' hypothesis predicting that children would control the contrast represented on the segmental level of linguistic description earlier than the contrast represented on the suprasegmental level (VOT before FSVL). Longitudinal acquisition patterns for both contrasts were compared in ten children between the mean ages of 1;6 and 2;0. The results, indicating that English-speaking children usually acquired VOT before FSVL, are discussed in light of evidence that French-speaking children acquire analogous contrasts in the opposite sequence. The crosslanguage comparisons support limited forms of both the motoric and representation hypotheses. As promising topics for further study, the results also suggested the importance of individual differences, and the variability of timing features in the input.

Child, Preschool↗
PubMed1997

Another look at nonverbal rule induction in children with SLI: testing a flexible reconceptualization hypothesis.

This study focuses on the ability of preschool children with specific language impairment (SLI) to extract target regularities from recurring nonverbal stimuli. As a step beyond previous methodologies, we also assessed their ability to shift and extract other regularities after feedback indicated that their choices were no longer correct. This step was motivated by Connell and Stone's (1994) hypothesis that difficulties manifested by children with SLI in extracting nonverbal "rules" from multiple problem sets may reflect difficulties in "flexible reconceptualization," that is, in the ability to flexibility shift across regularities. Thirty 4- and 5-year-olds with SLI and 30 age-matched children developing language normally participated in a discrimination learning-shift paradigm. Findings indicated that both language groups were successful in extracting regularities and making shifts. In fact, language groups did not differ in number of regularities extracted, number of shifts completed, or trials to criterion. As a consequence, findings failed to provide evidence that children with SLI are limited in either the ability to extract nonverbal regularities or to flexibly reconceptualize them. From a larger theoretical perspective, the findings fail to support theories positing that generalized "rule-induction" deficits underlie the verbal and nonverbal impairments of SLI.

Child, Preschool↗
PubMed1997

Prevalences of feline leukaemia virus and feline immunodeficiency virus infections in cats in Sydney.

OBJECTIVE: To determine prevalences of feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV) infections in 'healthy' cats that, through acute misadventure or other circumstance, were presented to veterinary practitioners. Prevalences of FeLV and FIV in this population were compared to those in a population of predominantly sick cats. DESIGN AND PROCEDURES: Serum specimens were obtained over a 2-year period from 200 cats older than 1 year of age presented to veterinary clinics for routine procedures, including cat fight injuries or abscesses, vehicular trauma, neutering, dental scaling, vaccination, grooming or boarding. An additional 894 sera were obtained over approximately the same period from specimens submitted by veterinarians to a private clinical pathology laboratory, mainly from sick cars suspected of having immune dysfunction, but including some sera from healthy cats being screened prior to FeLV vaccination. FIV antibody and FeLV antigen were detected in samples using commercial enzyme immunoassays. RESULTS: Amongst 200 'healthy' cats, the prevalence of FeLV infection was 0 to 2%, and the prevalence of FIV was 6.5 to 7.5%, depending on the stringency of the criteria used to define positivity. FIV infection was significantly more prevalent in cats which resided in an inner city environment (P = 0.013). Of the 894 serum specimens submitted to the laboratory by practitioners, 11/761 (1.4%) were FeLV positive, while 148/711 (20.8%) were FIV positive. The prevalence of FIV was significantly higher in these predominantly 'sick' cats than in cats seen for routine veterinary procedures (P < 0.00001), while there was no difference in the prevalence of FeLV (P = 0.75) CONCLUSIONS: The prevalence of FeLV and FIV in healthy cats may have been substantially overestimated in some previous Australian surveys. FeLV infection would appear to be a rare cause of disease in Australian cats. The higher prevalence of FIV positivity in sick as opposed to healthy cats infers that FIV infection contributes to the development of disease.

Animals↗
PubMed1996

Maternal pitch height in ordinary and play situations.

Ten children at mean ages of 0; 11.3 and 0;15.3 and their monolingual German-speaking mothers were audio- and videotaped in their homes while having a meal with a spoon (ordinary situation) and while feeding a doll with a spoon (play situation). Sentences spoken by the mothers that were comparable in length and sentence type across situations were analysed acoustically. In both data-collection sessions, it was found that the mothers spoke with the same mean amplitude in the two situations but they used higher mean fundamental frequency when speaking during the play situation than during the ordinary situation. In the first data-collection session, when the infants did not yet use meaningful words or engage in pretend play, the mothers also used a wider pitch range in the play situation than in the ordinary situation. It is concluded that mothers use both pitch height and pitch range to introduce the preverbal infant to the difference between non-play and play situations, and they continue to use variations in pitch height to mark the same distinction after the children have become active participants in pretend play activities. Implications of the results are discussed in terms of possible longitudinal patterns associated with mothers' use of intonational key and register.

Female↗
PubMed1994

Phrase-final syllable lengthening and intonation in early child speech.

This research describes the development of phrase-final prosodic patterns in nine English-speaking children. The intonation feature of interest is the fall in the fundamental frequency of the voice that occurs in the final syllables of statements. The corresponding feature of speech timing is phrase-final lengthening. The test opposing theories about the relationship between intonation and syllable timing, these boundary features were compared in a longitudinal study of the children's speech development between the mean ages of 16 and 25 months. The results suggest that young children acquire the skills that control intonation earlier than final syllable timing skills. The findings support the hypothesis tht final lengthening in the speech of 2-year-olds is a learned prosodic feature that cannot be accounted for as a secondary effect of inherent speech production constraints. In addition, a consistent pattern of final lengthening began to emerge when the children were making the transition to combinatorial speech, suggesting a developmental relationship between the child's learning of speech timing and syntax.

Child Language↗
PubMed1994

Learning and generalization components of morphological acquisition by children with specific language impairment: is there a functional relation?

Children with specific language impairment (SLI) have particular difficulty acquiring bound morphemes. To determine whether these morphological deficits spring from impairments of rule-induction or memory (storage/access) skills, 25 preschool-age children with normal language (NL) and 25 age-matched children with SLI were presented with a novel vocabulary and novel bound-morpheme learning task. A chi square analysis revealed that the children with SLI had significantly lower vocabulary learning levels than NL children. In addition, there was tentative evidence that a dependency relationship existed in some children between success in vocabulary learning and proficiency in generalizing a trained bound morpheme to untrained vocabulary stems. These findings are predicted by the storage/access but not the rule-induction theory of specific language impairment. They suggest that intervention targeting bound-morpheme skills acquisition in children with SLI might include attention to vocabulary development.

Child↗