Medications and their use in the treatment of adverse reactions to foods.
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Adrenal Cortex Hormones↗
Biomedical subjects
D Sogn
Publications and source records attributed to D Sogn.
The ubiquitous sulfites.
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Drug Hypersensitivity↗
Ontogeny of B lymphocyte function. X. Strain differences in maturation of the capacity of the B lymphocyte population to produce a high-affinity antibody response.
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Animals↗
Childhood dermatitis herpetiformis. Review of the new aspects and report of a case.
Dermatitis herpetiformis (DH) of linear IgA type occurred in a 6-month-old boy shortly after initiating sulfisoxazole therapy for a urinary tract infection. Generalized pruritic bullae on erythematous bases were present on his trunk and extremities. There were no clinical or laboratory findings suggestive of gastrointestinal involvement. Direct immunofluorescent studies of skin biopsies taken early in the course of the disease and while the child was on systemic corticosteroid therapy were negative. Eventually a linear deposition of IgA at the dermoepidermal junction of involved skin on direct immunofluorescence was demonstrated. No circulating antibodies to the basement membrane were found. Because of close proximity of the initiation of sulfisoxazole (Gantrisin) therapy and the eruption of the initial bullous lesions, this case also presents an interesting diagnostic and therapeutic problem. Negative assays of lymphocyte migration inhibition factor (LMIF) to sulfisoxazole indicated that the likelihood of a hypersensitivity reaction to sulfa drugs was slight. The patient's clinical response to dapsone therapy was dramatic. The conflicting views of subepidermal bullous dermatosis of childhood and the difficulties in confirming a diagnosis of DH are discussed. We contend that when DH is suspected in children, various laboratory tests should be repeated several times before the diagnosis can be confirmed. The case presented here is the youngest child reported with this type of DH.
Dapsone↗
On the correlation between rast and the allergy intradermal test.
RAST and intradermal testing correlated reasonably well for untreated patients for ragweed and molds and in treated patients for trees. Capillary blood was found to be comparable to venous blood as a source for RAST for ragweed and mixed grasses.
Adolescent↗