Biomedical subjects

D Sosnowska

Publications and source records attributed to D Sosnowska.

5 recordsLinked to original sources

PubMed1992

Monocytes are responsible for depressed natural killer (NK) activity in both young and elderly low NK responders.

Two age groups--young (19-35) and elderly (70-91)--were compared with respect to natural killer (NK) cytotoxic activity. In both groups, low and high NK responders could be distinguished. Low NK responders constituted about 70% of all elderly and 40% of young individuals. The differences in the magnitude of NK activity among the young and elderly groups could only be observed when peripheral-blood mononuclear cells but not peripheral-blood lymphocytes were used as effector cells in a 51Cr release assay. Experiments with removal or addition of graded numbers of monocytes showed that these cells were responsible for the low level of NK activity in both the young and elderly low NK responders.

Adult↗

PubMed1992

[Muroctasin, a muramyl dipeptide derivative].

This paper presents a review of studies on the metabolism, pharmacological and clinical properties of a new synthetic muramyl dipeptide derivative N2-/(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl/-N6-stearoyl-L-lysine(MD P- Lys(L18), muroctasin). Due to its effect on the number of peripheral blood leukocytes this compound is expected to be a useful drug for the treatment of leukopenia induced by cancer chemotherapy or radiation therapy.

Acetylmuramyl-Alanyl-Isoglutamine↗

PubMed1990

[Strongyloidiasis and its current treatment].

A case of strongyloidosis and giardiasis was observed in a women aged 62 years. The treatment included tinidazole, metronidazole and ercefuryl. Modern views on the epidemiology, clinical course and therapy of this parasitic infestation are discussed.

Antinematodal Agents↗

PubMed1990

[Toxocariasis].

Up to present time the data concerning toxocariasis++ have been presented. Toxocariasis++ is difficult for diagnosis because of lack of specificity and multiorgan changes due to the invasion by Toxocara canis or cati. We pay attention the problem distribution of this parasitosis in Poland and world is still actual especially among children. We have presented epidemiological data and means diagnosis of this diseases and the treatment patients and prophylaxis has been stressed.

Adult↗

PubMedDate not supplied

Natural killer sensitivity of tumor cells isolated from primary and metastatic lesions of four Bomirski melanoma variants.

Natural killer (NK) sensitivity of melanoma cells isolated from primary and metastatic lesions of four Bomirski melanoma variants was compared. The hamster melanomas differed in their growth rate and metastatic pattern. We found that during tumor growth of all the variants tested, NK sensitivity of melanoma cells at the metastasis formation stage was significantly lower in both primary and metastatic tumors than in cells isolated from primary tumors at transplantation. In the case of Ma, Ab and Ab-455, NK sensitivity of primary tumor cells was higher than that of the cells isolated from metastatic deposits. These data obtained from a spontaneous metastasis tumor model argue for the role of NK cells in preventing metastatic spread of Bomirski melanomas studied.

Animals↗