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Biomedical subjects

D Soumagne

Publications and source records attributed to D Soumagne.

9 recordsLinked to original sources
PubMed1986

Long-term sotalol therapy in patients with ventricular arrhythmias.

Sotalol, a beta adrenergic antagonist that prolongs action potential duration and refractoriness, was administered to ten patients with chronic, symptomatic ventricular ectopic activity. Eight patients had ischaemic heart disease, one patient congestive cardiomyopathy, and one patient atypical chest pain and no structural abnormality. Twenty-four hour Holter ECG tapes were analyzed during a drug-free period, and after three and six months of continuous Sotalol therapy. Satisfactory control of ventricular premature contractions was initially achieved in nine patients. Longer follow-up confirmed maintenance of antiarrhythmic efficacy in five (50%) patients. Sotalol was especially effective in reducing high grade arrhythmias (couplets, "R on T" VPCs). That efficacy and the low frequency of side-effects make Sotalol an agent of notable value in suppressing ventricular arrhythmias, especially in patients who require antianginal therapy.

Aged↗
PubMed1981

5-HT2-receptor blockade in the treatment of heart failure. A preliminary study.

Ketanserin (R 41 468), a quinazoline derivative, has been shown to be a selective blocker of 5-HT2 receptors. The drug was administered intravenously (10 mg given over a 3 min period) to 8 patients with severe cardiac failure already treated with digitalis, diuretics, and, in 4 cases, vasodilators. R 41 468 produced a significant fall in right-atrial, pulmonary-artery, pulmonary-wedge, and systemic arterial pressures. Systemic dynamic and total pulmonary vascular resistances were also reduced. Cardiac and stroke-work indices both increased, Heart rate remained unchanged. The platelet aggregation index, assessed in 2 patients, was initially low and was nearly normal 15 min after administration of a single dose of R 41 468.

Adult↗
PubMed1981

Prognostic significance of electrocardiographic findings in angina at rest. Therapeutic implications.

Ninety-five patients with angina at rest were observed in the coronary care unit. Eighty-one per cent presented concomitantly or had previously presented some other manifestations of coronary artery disease. These patients were divided into two subgroups. In subgroup 1 (40 patients), episodes of non-exertional angina were associated with a pattern of hyperacute subepicardial injury and, frequently, with ventricular arrhythmias. In subgroup 2 (55 patients), the episodes of angina at rest were attended by horizontal ST depression, isolated T wave inversion, or trivial ST-T changes. Coronary angiographic findings were similar in both subgroups. Symptoms regressed in only 9% of patients in subgroup 1 while they were receiving beta-receptor antagonists, whereas amiodarone alone or amiodarone with nifedipine was successful in 58%. Of these patients, 25% developed a myocardial infarction shortly after admission. In subgroup 2 patients, beta-blockers were successful in 61%. Amiodarone isolated or associated with nifedipine was successful in 55% of the patients in whom it was tried. Only 5% of patients in this subgroup developed a myocardial infarction during their hospital stay. It is concluded that: (1) observation of the electrocardiogram during spontaneous angina in patients with known atherosclerotic coronary heart disease may be of prognostic significance and may influence therapeutic decision. (2) Amiodarone by virtue of its anginal and antiarrhythmic properties may be particularly useful in the treatment of non-exertional angina.

Adrenergic beta-Antagonists↗