Biomedical subjects

D Stratmann

Publications and source records attributed to D Stratmann.

4 recordsLinked to original sources

PubMed1979

[Spinal anaesthesia using bupivacain--clinical experience of more than 6000 cases (author's transl)].

The following report of our experience using isobaric Bupivacaine 0.5% in 6,228 operations (intrathecal technique) will consider the intra operative period. In 55.8% of cases the lower extremities were operated upon and in 44.2% the lower abdomen. In 1,487 cases (23.9%) side effects/complications were evident and a classification of such is as follows: anaesthetic technique 5.29%, cardiorespiratory 15.69%, operator/operative technique 6.13%. The percentage remained relatively constant irrespective of age but a higher pre op risk classification (A.S.A. System) resulted in a marked increase in the above figures. The principal side effects encountered were as follows: Bradycardia 7.5%, hypotonia 6.3%, insufficient analgesia 3.9%, extrasystoles 2.9%. Grave complications occured in 0.15% and within this group 4 patients died intraoperatively; a relationship with the mode of anaesthesia has not been proven.

Aged↗

PubMed1979

[Postspinal headache -- a clinical problem (author's transl)].

A prospective study was made in 255 patients following spinal anaesthesia to detect the incidence of post operative headache, reference also being made to the size of needle used for lumbar puncture. There was a difference in the frequency of headache related to the size of needle used (9.7% with 22 gauge needle as against 6.7% with 25 gauge needle). Also the value of prophylaxis of headache by means of an epidural blood patch was shown (1.3%). Age also played a role, the older the patient, the less the risk of headache. The social class of the patient played no role at all.

Age Factors↗

PubMed1978

[Deep spinal anaesthesia and saddle-block technique in surgery during pregnancy (author's transl)].

The efficacy of peridural, spinal, and saddle-block technique in the operative treatment of the gravid patient is briefly described. Factors influencing height and spread of analgesia are indicated. In our series of 288 patients, where intrathecal techniques have been used, we compare the spread of analgesia in those positioned in the horizontal (following injection), and those propped to an angle of 45 degrees. We discuss the operative possibilities with such techniques. In conclusion we describe the side effects encountered and their treatment.

Analgesia↗

PubMed1975

Excretion of norephedrine by man after oral administration of oxyfedrine.

After oral administration of oxyfedrine to healthy volunteers, norephedrine was identified in the urine by thin layer chromatography and gas liquid chromatography and mass spectrography. 30 hours after single oral doses of 8, 16 or 24 mg of oxyfedrine, about 4, 8 and 9 mg, respectively, of norephedrine were found in the urine, i.e. on a molar base 75-100% of the dose was excreted as norephedrine. The peak of excretion occurred within 2-4 hours after administration of the drug. No accumulation of oxyfedrine and/or its metabolite was observed after administration of 16 mg of oxyfedrine t.i.d. for three days. It could not be decided whether oxyfedrine was metabolized to norephedrine by liver enzymes, as in rats, or was spontaneously degraded to norephedrine, e.g. in duodenal fluid before absorption. 30-150 min after oral oxyfedrine (24 mg) norephedrine was demonstrable in duodenal fluid. Thus, in addition to the direct beta-sympathomimetic effects of oxyfedrine, it may also have indirect sympathomimetic effects because of the noradrenaline-releasing properties of its metabolite norephedrine.

Administration, Oral↗