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Biomedical subjects

D Subrahmanyam

Publications and source records attributed to D Subrahmanyam.

At least 127 records · Page 7Linked to original sources

Effect of phenylhydrazine on the plasma lipids of albino rat.

The effect of phenylhydrazine hydrochloride on the lipid composition of plasma of albino rats have been investigated. The data revealed significant increase in the percentages of lysophosphatidyl choline and decrease in that of phosphatidyl choline. There was increase in the cholesterol ester content in the plasma. The assay of plasma lecithin-cholesterol acyltransferase (LCAT) activity showed a significant increase in its activity parallel to the above changes.

Animals↗

Trehalose of Culex pipiens fatigans.

Trehalose was found to occur in the mosquito, Culex pipiens fatigans, to the extent of 23 to 49% of total free sugars in different developmental stages of the insect. Induction of stress to the insects led to significant reduction in the trehalose of larvae and glucose of adults. The label from alpha,alpha'-U-14C-trehalose readily incorporated into lipids of the adults in which triglycerides seemed to undergo rapid turnover.

Animals↗

Myocardial lesions induced by prolonged alcohol feeding in rhesus monkeys.

To elucidate the effects of chronic alcohol ingestion in monkeys a synthetic, adequately balanced, fluid diet providing 40% of total calories from ethanol was gavaged through a stomach tube daily over a period of three months. Clinical, biochemical, radioisotope, and histopathological studies were performed at the beginning and end of the experiment. It was observed that chronic alcohol feeding at this dose level caused maked accumulation of triglycerides, cholesterol, and phospholipids in the serum and the liver. In the heart triglycerides and cholesterol ester were increased. Incorporation studies showed increased synthesis of triglycerides in the heart muscle and liver. Histologically the heart showed fatty change of the myocardium and evidence of focal myocytolysis, atrophy of muscle bundles, and early fibrosis. The liver showed generalized fatty change but no cirrhosis.

Alcohol Drinking↗