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Biomedical subjects

D T Domoto

Publications and source records attributed to D T Domoto.

22 records · Page 2Linked to original sources
PubMed1973

The ultrastructure of the adrenal zona glomerulosa of rats on patassium-supplemented or sodium-depleted diets.

Ultrastructural changes in the mitochondria and other organelles in zona glomerulosa cells of the adrenal cortex were noted in rats maintained for up to 8 days on a potassium-enriched or a sodium-deficient diet. In both groups of animals, aldosterone production is known to be increased. Principal ultrastructural changes in the rats maintained on a potassium-supplemented or a sodium-deficient diet consisted of a loss of electron density of the mitochondrial matrix and a change from plate-like cristae to tubular-vesicular cristae. These changes were similar in both potassium-enriched and sodium-depleted animals after 8 days and were markedly different from control animals. Morphologic changes occurred after the initial increase in aldosterone production, which has been measured in 1 to 2 days in both sodium-depleted and potassium-enriched rats. The mitochondrial changes described are probably related to the persistent increased active steroid synthesis.

Adrenal Glands↗
PubMedDate not supplied

Recurrent venous thrombosis associated with permanent internal jugular vein hemodialysis catheters.

Eight Permcaths were placed into seven patients without other alternative hemodialysis access sites. They lasted from 1-109 treatments. However, recurrent thrombi formed at the tip of two catheters. Although urokinase successfully dissolved the thrombi, recurrence of clot despite anticoagulation therapy led to removal of both catheters. We conclude that the Permcath should be used with caution in patients on hemodialysis who have no alternative vascular access sites because of the risk of thromboembolism. The value of anticoagulants to prevent recurrent thrombi is unclear, because thrombi recurred in both patients despite their use.

Aged↗
PubMedDate not supplied

The significance of electron dense deposits in mild lupus nephritis.

In patients with lupus nephritis, progression from a mild lesion to a diffuse proliferative glomerulonephritis has been reported in one to 35 percent of patients. Because of the wide variation in the rate of progression, this study was undertaken to determine those factors which would identify the patients most likely to progress. Of 21 patients with a mild lupus nephritis by light microscopy, progression to a diffuse proliferative lesion was seen in only those patients who had subendothelial deposits. While not all patients with subendothelial deposits had a deteriorating course, the persistence of such deposits on subsequent biopsies indicated a poor prognosis.

Adolescent↗